Extraction of conductivity and permittivity using magnetic resonance imaging

Haacke, E. Mark; Petropoulos, L. S.; Nilges, E W; Wu, Dee H.

doi:10.1088/0031-9155/36/6/002

Cited by 171 publications

(181 citation statements)

References 11 publications

Supporting

Mentioning

179

Contrasting

Order By: Relevance

“…These field perturbations can be used to estimate the spatial distribution of electrical properties within the objects giving rise to the perturbations. Early work in MR-EPT was published in 1991 [1], but the technique has only recently seen a resurgence of exploration due to the clinical potential that the electrical properties may offer in terms of tissue contrast. Several groups have focused on developing novel image reconstruction methods and algorithms for this purpose.…”

Section: Agnetic Resonance-electrical Prop-erties Tomography (Mr-ept)mentioning

confidence: 99%

“…This program builds off of our extensive experience in using electrical properties of prostate to distinguish malignant from benign tissues [1][2][3][4][5] and specifically stems from exciting new data published in The Prostate [6] in which we demonstrated significant electrical property differences between high-and low-grade prostate cancer. These electrical properties are influenced by a tissue's intra-and extra-cellular composition, morphology, and cellular constituency, and we have hypothesize that it is possible to use these properties to discriminate between normal, low-grade, and high-grade malignant formations in a clinical setting.…”

Section: Introductionmentioning

confidence: 99%

“…The primary objective of this current program is to develop a highresolution MR-based approach to imaging the electrical properties of prostate with the intent of producing a system potentially able to image cancer grade. This is possible by leveraging ultra-novel developments in MRI, and our extensive experience in developing technologies to gauge and assess the utility of electrical properties for prostate cancer detection [1][2][3][4][5][6] and assessment and in developing computer algorithms to transform electromagnetic data into electrical property images of the prostate [7][8][9][10][11][12][13][14]. Specifically, we are attempting to use the maps of MRI RF field data acquired with safe and fast sequences to create high-resolution electrical property images of the prostate.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Magnetic Resonance-Based Electrical Property Tomography (MR-EPT) for Prostate Cancer Grade Imaging

College¹

2016

View full text Add to dashboard Cite

Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTDetermining whether a man recently diagnosed with prostate cancer has aggressive disease requiring immediately radical therapy or indolent disease requiring a more passive watchful waiting or active surveillance approach is a current clinical challenge. This technology development study is focused on developing Magnetic Resonance -Electrical Property Tomography (MR-EPT) specifically for prostate imaging. MR-EPT is an imaging modality that may enable clinicians to image the electrical properties of prostate at near MR resolution. These electrical properties are hypothesized to provide sufficient contrast for distinguishing between aggressive and indolent prostate cancer. Much of the third year of this program has focused on additional MR-EPT image reconstruction algorithm development and optimization, experimental imaging of both simplistic and anatomically accurate phantoms, continued recruitment for ex vivo and in vivo prostate imaging, and statistical analysis of ex vivo prostate data. During this year we have demonstrated additional imaging capabilities of MR-EPT through phantom studies, have recruited and imaged the majority of our proposed ex vivo cohort of prostates, and continued recruitment for the in vivo imaging phase of this program. The no-cost-extension 6 months of the program will primarily focus on completing our in vivo data acquisition, statistical analysis of our data, and preparation of publications and proposals for follow-on more clinically focused studies. INTRODUCTIONThis program builds off of our extensive experience in using electrical properties of prostate to distinguish malignant from benign tissues [1][2][3][4][5] and specifically stems from exciting new data published in The Prostate [6] in which we demonstrated significant electrical property differences...

show abstract

Section: Agnetic Resonance-electrical Prop-erties Tomography (Mr-ept)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Magnetic Resonance-Based Electrical Property Tomography (MR-EPT) for Prostate Cancer Grade Imaging

College¹

2016

View full text Add to dashboard Cite

show abstract

“…A primitive approach to solve Eq. (3) is to reduce it into an algebraic equation by neglecting the spatial gradient of κ. Haacke et al [12] and later Wen [13] introduced a formula κ = −(ΔH + )/(ω 2 μ 0 H + ) by assuming that ∇κ = 0; stabilized versions of this approach were also proposed [14], [15]. However, the assumption that ∇κ 0 results in severe artifacts in the tissue transition regions where EPs vary [16], [17].…”

Section: Introductionmentioning

confidence: 99%

A Boundary-Value-Free Reconstruction Method for Magnetic Resonance Electrical Properties Tomography Based on the Neumann-Type Integral Formula over a Circular Region

Fushimi

Nara

2017

SICE Journal of Control, Measurement, and System Integration

View full text Add to dashboard Cite

: The electrical properties (EPs) of biological tissue, consisting of conductivity and permittivity, provide useful information for the diagnosis of malignant tissues and the evaluation of heat absorption rates. Recently, magnetic resonance electrical properties tomography (MREPT), by which EPs are reconstructed from internal magnetic field data measured by using magnetic resonance imaging (MRI), has been actively studied. We previously proposed an explicit pointwise reconstruction method for MREPT based on a complex partial differential equation (PDE), known as the D-bar equation, of the electric field and its explicit solution given by an integral formula. In this method, as in some other conventional methods, EP values on the boundary of the region of interest must be given as a Dirichlet boundary condition of the PDE. However, it is difficult to know these values precisely in practical situations. Therefore, in this paper, we propose a novel method for reconstructing EPs in a circular region without any knowledge of boundary EP values. Starting from the integral solution to solve the D-bar equation in a circular region with the Neumann boundary condition, we show that the contour integral term of the integral formula is eliminated by using Faraday's law and solve the PDE based only on magnetic field data measured by using MRI. Numerical simulations show that the proposed method yields a good reconstruction results without any knowledge of boundary EP values.

show abstract

“…Rotation of the spins results in a measurable NMR signal. Haacke et al [2] proposed the idea of extracting the tissue parameters from MR data already in 1991. More recently, Katscher et al [3] introduced Electric Property Tomography (EPT) as a means of retrieving the conductivity and permittivity of different tissue types.…”

Section: Introductionmentioning

confidence: 99%

CSI-EPT: A novel contrast source approach to MRI based electric properties tomography and patient-specific SAR

Balidemaj

Trinks

Berg

et al. 2013

2013 International Conference on Electromagnetics in Advanced Applications (ICEAA)

View full text Add to dashboard Cite

show abstract

Extraction of conductivity and permittivity using magnetic resonance imaging

Cited by 171 publications

References 11 publications

Magnetic Resonance-Based Electrical Property Tomography (MR-EPT) for Prostate Cancer Grade Imaging

Magnetic Resonance-Based Electrical Property Tomography (MR-EPT) for Prostate Cancer Grade Imaging

A Boundary-Value-Free Reconstruction Method for Magnetic Resonance Electrical Properties Tomography Based on the Neumann-Type Integral Formula over a Circular Region

CSI-EPT: A novel contrast source approach to MRI based electric properties tomography and patient-specific SAR

Contact Info

Product

Resources

About