Extraction of cephalosporin C using supported liquid membrane

Ghosh, Anil C.; Borthakur, S.; Roy, Mahua; Dutta, Narendra Nath

doi:10.1016/0956-9618(95)00114-l

Cited by 23 publications

(8 citation statements)

References 14 publications

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“…can be easily calculated solely from the molecular structure (Hano et al, 1992;Ghosh et al, 1997) and applied for prediction of certain membrane permeation properties (Patil et al, 1995;Li, 1975). Using the liquid membrane technique, we have demonstrated the feasibility of separation of various cephalosporin molecules (Sahoo et al, 1996(Sahoo et al, , 1997(Sahoo et al, , 1998Ghosh et al, 1995). Such liquid membranes can be effective for separation of carboxylic acids as well as amino acids (Lazarova and Peeva, 1994;Thein et al, 1988;Reisinger and Marr, 1993).…”

Section: G C Sahoo Er A/mentioning

confidence: 94%

Liquid Membrane Transport of Cephalosporin Antibiotics: Effect of Solute Chemical Nature on Carrier Specificity

Sahoo

Dutta

Dass

2000

Chemical Engineering Communications

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Cephalosporin antibiotics were transported from a dilute aqueous solution (feed phase) through a bulk liquid membrane containing Aliquat-336 as an anion exchange carrier in n-butyl acetate as the solvent to another aqueous solution (receiving phase) of lower pH. Under appreciable pH gradient of the feed and receiving phases, facilitated uphill transport could be obtained. Under the optimal pH condition, the intial solute flux across the bulk liquid membrane could be correlated well with the hydrophobicity of the solutes. A linear correlation exists between the initial solute flux and hydrophobicity, indicating that the solute of higher hydrophobic nature are transported at a higher rate in the bulk liquid membrane involving the specific carrier. The correlation appears to be derived from a linear dependenc of solute hydrophobicity on equilibrium constant of the reactive extraction system being exploited in the bulk liquid membrane.

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Section: G C Sahoo Er A/mentioning

confidence: 94%

Liquid Membrane Transport of Cephalosporin Antibiotics: Effect of Solute Chemical Nature on Carrier Specificity

Sahoo

Dutta

Dass

2000

Chemical Engineering Communications

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“…Since we do not anticipate any enhancement in their values by further increasing the stirrer speed (leading to phase dispersion), we presume that some other physio-chemical processes occuring at the interface affect the extraction rate. It is known that Aliquat-336 is a surface acting agent and lowering of interfacial tension between the aqueous solution and the butyl acetate is quite significant at high [ P O ] as reported in our previous work (Ghosh et al, 1995). The extraction kinetics may be analysed from an interfacial reaction model incorporating the effect of camer adsorption at the interface.…”

Section: Extraction Kineticsmentioning

confidence: 95%

“…In view of this, reactive cxtraction has been extensively studied for penicillin-(; (Likidis et al, 1987;Schugerl, 1984, 1985); cephalosporin-C ; clavulanic acid, penicillin G and V, amoxicillin and phenyl acetic acid (Harris et al, 1990), etc. Furthermore, the concept has been exploited to develop liquid membrane processes where facilitated transport could be realised to give high flux and selectivity (Thien et al, 1990;Lee et al, 1993Likidis and Schugerl, 1987;Lee and Lee, 1992;Ghosh et al, 1995;Sahoo et al, 1996). Various aspects of extraction and purification of beta-lactam antibiotics in general and the liquid membrane process in particular have been recently reviewed by the authors (Ghosh et al, 1996(Ghosh et al, , 1997.…”

mentioning

confidence: 99%

Reactive extraction of 6‐aminopenicillanic acid with aliquat‐336: Equilibrium and kinetics

et al. 1997

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The reactive extraction of 6-aminopenicillanic acid (6-APA) from aqueous buffer solution has been studied using a liquid anion exchanger, tricaprylylmethyl ammonium chloride (Aliquat-336) in n-butyl acetate as the solvent. The extraction equilibrium constant and partition coefficient increase with increase in pH up to a limiting value of pH, beyond which extraction decreases due to coextraction of OH-and buffer anions and hydrolytic decomposition of 6-APA. The experimental data could be predicted from an equilibrium model which takes into account the ideal behaviour of the two liquid phases. The coextraction of the buffer anion under low pH conditions was found to be negligible. The extraction rate measured in a stirred cell of constant interfacial area appears to be dependent on the interfacial mass transfer of the reactive species as well as on the interfacial reaction through its dependence on the concentration of 6-APA in the aqueous and organic phases, respectively.On a etudie I'extraction reactive de I'acide 6-aminopenicillanique d'une solution tampon aqueuse a I'aide d'un echangeur d'anions liquide, le chlorure d'amrnonium tricaprylylmethyl (Aliquat-336) dans du n-butyl acetate coinme solvant. La constante d'equilibre d'extraction et le coefficient de partition augmentent avec le pH jusqu'a une valeur limitante du pH, au-dela de laquelle I'extraction diminue en raison de la coextraction de OH-et des anions tampons ainsi que de la decomposition hydrolytique de 6-APA. Les donnees experimentales peuvent etre exprimees a partir d'un modele d'equilibre qui tient compte du comportement ideal des deux phases liquides. La coextraction de I'anion tampon dans de faibles conditions de pH s'avere negligeable. I1 apparait que la vitesse d'extraction mesuree dan une cellule agitee de surface interfaciale constante depend du transfert de matere interfacial des especes reactives et de la reaction interfaciale par I'entremise de la concentration de 6-APA dans les phases aqueuse et organique respectivement.

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“…(27), a result that probably implies the hypothesis of an interfacial reaction control mechanism for the extraction of 7-ACA with Aliquat-336 which has good surfactant properties. Indeed significant lowering of the interfacial tension between on aqeous cephalosporin solution and butyl acetate solution of Aliquat-336 could be demonstrated as an important factor for stability of an immoblized liquid membrane system (Ghosh et al, 1995) wherein the principle of reactive extraction was exploited.…”

Section: Effect Of Carrier Concentrationmentioning

confidence: 99%

“…We have been studying the liquid membrane technique for extraction of cephalosporin antibiotics. By suitably manipulating the aqueous phase environment in the feed and stripping phases and selecting the extracting agent (carrier) for the membrane phase, facilitated transport in the membrane could be demonstrated atleast for CPC, 7-ACA and cephalexin (Ghosh et al, 1995;Sahoo et al, 1996Sahoo et al, ,1997Sahoo et al, ,1999. Complimentary studies on equilibrium and kinetics of the reactive extraction of these compounds are being made separately in our laboratory as these data are useful for optimising the operating conditions of liquid membrane processes.…”

Section: Introductionmentioning

confidence: 97%

Reactive Extraction of 7-Aminocephalosporanic Acid With Aliquat-336: Equilibrium and Kinetics

Bora

Dutta

Bhattacharya

2000

Chemical Engineering Communications

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Extraction of cephalosporin C using supported liquid membrane

Cited by 23 publications

References 14 publications

Liquid Membrane Transport of Cephalosporin Antibiotics: Effect of Solute Chemical Nature on Carrier Specificity

Liquid Membrane Transport of Cephalosporin Antibiotics: Effect of Solute Chemical Nature on Carrier Specificity

Reactive extraction of 6‐aminopenicillanic acid with aliquat‐336: Equilibrium and kinetics

Reactive Extraction of 7-Aminocephalosporanic Acid With Aliquat-336: Equilibrium and Kinetics

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