Extraction of biologically active compounds from Sideritis ssp. L.

Tsibranska, I.; Tylkowski, Bartosz; Kochanov, Ruslan; Alipieva, Kalina

doi:10.1016/j.fbp.2010.10.004

Cited by 30 publications

(20 citation statements)

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“…Previous reports on S. syriaca were mainly focused on methanol, ethyl acetate, hexane, petroleum ether, and dichloromethane extract as well as its essential oil (Armata et al, 2008;Gonzalez-Burgos & Carretero, 2011;Petreska et al, 2011a;Plioukas et al, 2010;Tsibranska, Tylkowski, Kochanov, & Alipieva, 2011). The objective of the present study was a thorough exploration of the bioactive composition, as well as the antioxidant and antimicrobial properties of mountain tea decoction as it is usually consumed.…”

Section: Introductionmentioning

confidence: 97%

Evaluation of the phytochemical content, antioxidant activity and antimicrobial properties of mountain tea (Sideritis syriaca) decoction

Goulas

Exarchou

Kanetis

et al. 2014

Journal of Functional Foods

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Section: Introductionmentioning

confidence: 97%

Evaluation of the phytochemical content, antioxidant activity and antimicrobial properties of mountain tea (Sideritis syriaca) decoction

Goulas

Exarchou

Kanetis

et al. 2014

Journal of Functional Foods

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“…Conventional extraction experiments were carried out in a stirred vessel for 24 h following a protocol developed and normalized in our previous study 30,31 . The obtained yield of extraction with milli-Q water as solvent was 0.02 g/(g dry solid).…”

Section: Resultsmentioning

confidence: 99%

Stability and anti-proliferative properties of biologically active compounds extracted from Cistus L. after sterilization treatments

Ammendola

Haponska

Balik

et al. 2020

Sci Rep

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The growing interest of oncologists in natural compounds such as polyphenols and flavonoids is encouraging the development of innovative and efficient carriers for the delivery of those drugs. This study examines carboxymethyl chitosan-based microcapsules created by spray drying as a method for delivering biologically active compounds isolated from the Cistus herb. Effects of sterilization and encapsulation on the polyphenol and flavonoid content of Cistus extract were investigated to optimize the production process. Furthermore, in vitro studies were carried out to examine the anticancer properties of sterilized polyphenols and flavonoids on glioblastoma cells isolated from oncological patients. Acquired results show high anticancer potential towards glioblastoma as well as low cytotoxicity towards non-cancer cell lines by the substances in question. Steam sterilization is shown to affect the content of biologically active compounds the least. We demonstrate that the investigated form of drug encapsulation is both efficient and potentially possible to scale up from the viewpoint of the pharmaceutical industry. According to apress statement launched by the International Agency for Research on Cancer from the World Health Organization (WHO), in 2018the global cancer burdenaffected 18.1 million new cases and 9.6 million of people passed away. Ten in 50 men and one in 60 women worldwide suffer from cancer during their life, and ten in 80 men and eleven in 110 women posse awaydue to thisillness. Moreover, cancer is a most frequent causeof children death. Worldwide, every year, approximately 300.000 of children are diagnosed by oncologists with a cancer disease 1,2. Furthermore, according to the published statistic data, the total number of people who are alive within 5 years of a cancer diagnosis, called the 5-year prevalence, is arround 43.8 million 3. As stated in the WHO report,the frequent types of cancer in men are cancer of lung, prostate, colorectal, stomach and liver, while in case on women, the most common type of cancer are: breast, colorectal, lung, cervix and thyroid cancer. The uncontrollable growth of tumor cells is the most fundamental aspect of cancer 4. Even if available therapies such as surgery, immunotherapy, chemotherapy, targeted therapy, hormone therapy and radiation therapy play a significant role in cancer treatment, drug resistance and toxicity remain main problems and challenges to cure cancer patients 5. Oncologists have called for basic investigationsand new upstream technologieswhich insustainably, efficiently and safely way will meet the current and future patients' needs 6,7. Additionally, during the last years the "integrative" oncology society has demanded advancesfrom scientists on the development of natural medicals 8,9. Indeed, the anticancer effects of biologically active compounds, such as natural polyphenols synthesized by fruits, vegetables, teas, apples, cocoa and other plants, have become a hot topic in many laboratories 10-12 .

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“…Äaeåðåëîì ôåíîëüíèõ ñïîëóê ìîaeå ñëóãóâàòè ë³êàðñüêà ðîñëèíà ãîðèöâ³ò âåñíÿíèé (Adonis vernalis), à ñàìå ¿¿ íàäçåìíà ÷àñòèíà [2,3]. Îñíîâíèì ïðîöåñîì, ùî çàñòîñîâóºòüñÿ äëÿ îäåðaeàííÿ ôåíîëüíèõ ñïîëóê ç ðîñëèí-íî¿ ñèðîâèíè º åêñòðàãóâàííÿ [4][5][6]. Äî òðàäè-ö³éíèõ ìåòîä³â åêñòðàãóâàííÿ ó ôàðìàöåâòè÷í³é ïðîìèñëîâîñò³ íàëåaeèòü âîäíî-ñïèðòîâà åêñò-ðàêö³ÿ.…”

Section: âñòóïunclassified

Extraction of phenolic compounds from the plant Adonis vernalis

2019

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Extraction of biologically active compounds from Sideritis ssp. L.

Cited by 30 publications

References 29 publications

Evaluation of the phytochemical content, antioxidant activity and antimicrobial properties of mountain tea (Sideritis syriaca) decoction

Evaluation of the phytochemical content, antioxidant activity and antimicrobial properties of mountain tea (Sideritis syriaca) decoction

Stability and anti-proliferative properties of biologically active compounds extracted from Cistus L. after sterilization treatments

Extraction of phenolic compounds from the plant Adonis vernalis

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