Extraction of bioflavonoid mixture from onion husk by subcritical water

Lekar, A. V.; Filonova, O. V.; Borisenko, S. N.; Maksimenko, E. V.; Vetrova, E. V.; Borisenko, N. I.

doi:10.1134/s1990793113070117

Cited by 18 publications

(9 citation statements)

References 12 publications

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“…The hydrolysis products of ammonium glycyrrhizinate were obtained using different hydrolysis schemes in order to analyze quantitatively and qualitatively the compositions of the targeted products of hydrolysis. Our previous studies [15,16] showed that the transformations of biologically active compounds in subcritical water were most complete in the temperatures range of 100 -300°C. Therefore, here we studied in detail the temperature dependence of the yield of hydrolysis products in this temperature range and the composition of the products obtained.…”

mentioning

confidence: 99%

Study of an Acid-Free Technique for the Preparation of Glycyrrhetinic Acid from Ammonium Glycyrrhizinate in Subcritical Water

Lekar

Borisenko

Vetrova

et al. 2015

Natural Product Communications

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The aim of this work was to study an application of a previously developed expedient acid-free technique for the preparation of glycyrrhetinic acid from ammonium glycyrrhizinate that requires no use of acids and toxic organic solvents. Subcritical water that serves as a reactant and a solvent was used in order to obtain glycyrrhetinic acid in good yields starting from ammonium glycyrrhizinate. It has been shown that variation of only one parameter of the process (temperature) allows alteration to thecomposition of the hydrolysis products. A new method was used for the synthesis of glycyrrhetinic acid (glycyrrhizic acid aglycone) and its monoglycoside. HPLC combined with mass spectrometry and NMR spectroscopy were used to determine the quantitative and qualitative compositions of the obtained products. The method developed for the production of glycyrrhetinic acid in subcritical water is environmentally friendly and faster than conventional hydrolysis methods that use acids and expensive and toxic organic solvents. The proposed technique has a potential for the future development of inexpensive and environmentally friendly technologies for production of new pharmaceutical plant-based substances.

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mentioning

confidence: 99%

Study of an Acid-Free Technique for the Preparation of Glycyrrhetinic Acid from Ammonium Glycyrrhizinate in Subcritical Water

Lekar

Borisenko

Vetrova

et al. 2015

Natural Product Communications

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“…[7] Previously, the study of the thermal treatment of QR and RT in an aqueous model system (cooking) was carried out in detail in the work of Buchner et al . [8] QR and RT were heated (100°C) and their degradation was studied by HPLC.…”

Section: Resultsmentioning

confidence: 99%

“…[ 6 ] In recent years, subcritical water has been used as a cheap, environmentally friendly solvent for extraction, synthetic transformations and the recycling of different organic wastes as, for example, agricultural production process in wastes. [ 7 ]…”

Section: Introductionmentioning

confidence: 99%

A simple way for the preparation of natural antioxidant quercetin from rutin by subcritical water

Vetrova¹,

Maksimenko²,

Khizrieva³

et al. 2017

J Nat Sc Biol Med

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Context:Quercetin (QR) is a natural strong antioxidant of the plant origins. It is used for treating conditions of heart and blood vessels including “hardening of arteries” (atherosclerosis), high cholesterol, heart disease, circulation problems, preventing cancer, for treating chronic infections of the prostate, etc.,Aims:The aim of this work was to development and study of an acid-free technique for the preparation of QR from rutin (RT) that requires no use of acids and toxic organic solvents.Materials and Methods:For the first time, the subcritical water that serves as a reactant and a solvent were used to obtain QR in good yields starting from RT. High-performance liquid chromatography combined with mass spectrometry was used to determine the quantitative and qualitative compositions of the obtained products.Conclusions:For the first time, a new acid-free technique was used for the synthesis of natural antioxidant QR from an RT by subcritical water. That way requires no use of acids and/or toxic organic solvents. It has been shown that variation of only one parameter of the process (temperature of subcritical water) allows alteration to the composition of the hydrolysis products. The new method developed for the production of QR in subcritical water is environmentally friendly and faster than conventional hydrolysis methods that use acidic or enzymatic hydrolysis. The proposed technique has a potential for the future development of inexpensive and environmentally friendly technologies for the production of new pharmaceutical plant-based substances.

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“…At increasing temperature of subcritical water, quantitative and qualitative composition of the extracts was varied. That leaded to the increasing the amount of aglycones in the extracts, because of acidic hydrolysis of flavonoid glycosides can occur during extraction process in subcritical water (Lekar et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

EXTRACTION OF QUERCETIN FROM <i>POLYGONUM HYDROPIPER</i> L. BY SUBCRITICAL WATER

Lekar

Borisenko

Vetrova

et al. 2014

American Journal of Agricultural and Biological Sciences

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Extraction of bioflavonoid mixture from onion husk by subcritical water

Cited by 18 publications

References 12 publications

Study of an Acid-Free Technique for the Preparation of Glycyrrhetinic Acid from Ammonium Glycyrrhizinate in Subcritical Water

Study of an Acid-Free Technique for the Preparation of Glycyrrhetinic Acid from Ammonium Glycyrrhizinate in Subcritical Water

A simple way for the preparation of natural antioxidant quercetin from rutin by subcritical water

EXTRACTION OF QUERCETIN FROM <i>POLYGONUM HYDROPIPER</i> L. BY SUBCRITICAL WATER

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