Extraction of antioxidant compounds from different varieties of Mangifera indica leaves using green technologies

Férnandez-Ponce, M.T.; Casas, Lourdes; Mantell, Casimiro; Rodríguez, Miguel; Ossa, E.J. Martı́nez de la

doi:10.1016/j.supflu.2012.07.016

Cited by 98 publications

(43 citation statements)

References 36 publications

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“…Some of the methods opted are Soxhlet extraction, microwave-assisted extraction, and subcritical 5 extraction using solvents. However, the pitfalls associated with the use of these traditional techniques are the usage of high amount of solvents for extraction, more time consumption and economically less feasible [13]. To overcome these hiccups, various new techniques like supercritical fluid extraction (SFE) [14] and pressurized liquid extraction (PLE) [15], have been lately opted by researchers to obtain maximal yield in shorter time span.…”

Section: Source Of Mangiferin: Extraction and Isolationmentioning

confidence: 99%

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Mangiferin: a Promising Anticancer Bioactive

et al. 2016

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Of late, several biologically active antioxidants from natural products have been investigated by the researchers in order to combat the root cause of carcinogenesis, i.e., oxidative stress. Mangiferin, a therapeutically active C-glucosylated xanthone, is extracted from pulp, peel, seed, bark and leaf of Mangifera indica. These polyphenols of mangiferin exhibit antioxidant properties and tend to decrease the oxygen-free radicals, thereby reducing the DNA damage. Indeed, its capability to modulate several key inflammatory pathways undoubtedly helps in stalling the progression of carcinogenesis. The current review article emphasizes an updated account on the patents published on the chemopreventive action of Mangiferin, apoptosis induction made on various cancer cells, along with proposed antioxidative activities and patent mapping of other important therapeutic properties. Considering it as promising polyphenol, this paper would also summarize the diverse molecular targets of Mangiferin.

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Section: Source Of Mangiferin: Extraction and Isolationmentioning

confidence: 99%

“…Osteen, Kensington, Kent and Ataulfo. The extract showed highly potent in vitro antioxidant activity [13]. However, another scientific group, Kim et al, reported the extraction of Mgf from Mahkota Dewa employing same methodology, but making use of supercritical fluids [16].…”

Section: Source Of Mangiferin: Extraction and Isolationmentioning

confidence: 99%

Mangiferin: a Promising Anticancer Bioactive

et al. 2016

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“…A comparison between SWE and supercritical CO 2 was done by Fernández-Ponce et al [26] for antioxidant extraction from mango leaves. On the same system, two dynamic methods were used on crushed leaves.…”

Section: Applicationsmentioning

confidence: 99%

Water as Green Solvent for Extraction of Natural Products

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Özel

Périno

et al. 2015

Green Extraction of Natural Products

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IntroductionWater is the most abundant molecule on the earth, covering 70% of its surface. Life processes on this planet are crucially dependent on the presence of water. It is often recognized that water has tremendous benefits as a green extraction solvent because it is not only inexpensive and environmentally benign but it is also nonflammable and nontoxic, providing opportunities for clean processing and pollution prevention. The water molecule contains three nuclei, one modestly heavy (oxygen), and two light ones (hydrogen). Because of water's electronic structure, the oxygen atom has a slight negative charge on it and the hydrogen atoms have a slightly positive charge [1]. When water molecules are closed together, their positive and negative regions are attracted, these attractive forces are known as hydrogen bonds. The energy associated with a hydrogen bond is 8-40 kJ/mol. The O-H bond lengths are 0.9572 Å and the average HOH bond angle is 104.52 ∘ , slightly smaller than the tetrahedral angle (109.5 ∘ ). The molecule is very small with a hard sphere diameter of 2.75 Å. The smallness of the water molecule has important consequences for the hydration of solutes. The contours of the total electron density in the HOH plane of the water molecule indicate a shape not far from spherical. The water molecule has a dipole moment of 1.85 D with two partial positive charges on the hydrogen atoms and a single zone of negative charge on the oxygen atom.It is well known that water molecules are strongly associated in the liquid phase by H-bonding. Hydrogen bonds result dominantly from electrostatic interactions with a light contribution of covalent bond formation. The H-bond interactions in liquid water constitute a 3-D H-bond network with localized and structured clustering. Therefore, the liquid structure is not determined by hard-core repulsions between the individual water molecules but rather by intermolecular and directional H-bonding. The broad variation of H-bond angles further demonstrates the noncrystalline arrangement of the water molecules and appears to indicate that some bond angle distortion in the H-bonds is rather easily allowed in the liquid. It is important to recognize that intermolecular interaction Green Extraction of Natural Products: Theory and Practice, First Edition. Edited by Farid Chemat and Jochen Strube.

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“…Mangifera indica leaves contain phenolic secondary metabolites, including gallic acid, quercetin 3-β-D glucoside, α tocopherol, 3-methyl-gallate, propyl gallate, propyl benzoate (+) catechin, (−) epicatechin, benzoic acid and D-glucose [12,13]. Mangiferin (1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one), of the xanthone group (Figure 1), is a major constituent of the leaves and stem bark of Mangifera indica L. (Anacardiaceae) and has antioxidant, immunomodulatory and anti-inflammatory activities [14].…”

Section: Introductionmentioning

confidence: 99%

Extraction of Mangiferin and Chemical Characterization and Sensorial Analysis of Teas from Mangifera indica L. Leaves of the Ubá Variety

et al. 2016

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Abstract:Mangiferin is present in various parts of Mangifera indica L. and has proven biological activities, such as antioxidant capabilities. The aim of this work was to evaluate the chemical composition of teas prepared from M. indica leaves, their potential use as a source of mangiferin and their total phenolic compounds. Teas were prepared with young and mature leaves of M. indica at three (medicinal plant: solvent) ratios utilizing three different preparation techniques. The mangiferin content was analyzed via high-performance liquid chromatography (HPLC). The tea with the highest mangiferin content was characterized for its total phenolic content and antioxidant activity. The oxidative stability was also evaluated by quantifying mangiferin, total phenolics and antioxidant activity using two preservation treatments for 0, 24 and 48 h. Sensory analysis was performed to measure the acceptance of the tea. The type of leaf, preparation technique and concentration influenced the mangiferin content in the teas. The highest concentration of mangiferin was obtained through decoction at a 5% (w/v) medicinal plant concentration. This tea exhibited stability up to 48 h after preparation under both preservation treatments and provided a positive sensory acceptance for consumers with flavors added. In conclusion, teas made from M. indica leaves have great potential as sources of mangiferin and phenolic compounds.

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Extraction of antioxidant compounds from different varieties of Mangifera indica leaves using green technologies

Cited by 98 publications

References 36 publications

Mangiferin: a Promising Anticancer Bioactive

Mangiferin: a Promising Anticancer Bioactive

Water as Green Solvent for Extraction of Natural Products

Extraction of Mangiferin and Chemical Characterization and Sensorial Analysis of Teas from Mangifera indica L. Leaves of the Ubá Variety

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