Extraction of antidepressant drugs in biological samples using alkanol‐based nano structured supramolecular solvent microextraction followed by gas chromatography with mass spectrometric analysis

Abstract

In the present study, a supramolecular solvent was formed from reverse micelle aggregates of octanol. The proposed supramolecular solvent was used for rapid extraction of some antidepressants drugs including amitriptyline, imipramine, desipramine, maprotiline, sertraline, and doxepin from biological samples. Alkanol-based supramolecular solvents have a unique array of physicochemical properties, making them a very attractive alternative to replace organic solvents in analytical extractions. The parameters affecting the extraction of target analytes (i.e., the volume of tetrahydrofuran and octanol as the major components comprising the supramolecular solvent, chain length of alkanols, sample solution pH, salt addition, and ultrasonic time) were investigated and optimized by factor by factor optimization method. Under the optimum conditions, preconcentration factors of 470, 490, 460, 385, 370, and 430 were obtained for amitriptyline, doxepin, imipramine, desipramine, maprotiline, and sertraline, respectively. The linear ranges and coefficients of determination (R 2 ) were obtained in the range of 0.01-100 μg/L and 0.9974-0.9991, respectively. Also the limits of detection (S/N = 3) of 0.003-0.03 μg/L, and precisions (n = 5) of 4.9-8.9% were calculated. Finally, the method was successfully applied for the extraction of antidepressant drugs in biological samples, and relative recoveries in the range of 91-102% were obtained.

Separation of antipyretic analgesics by open tubular capillary electrochromatography with homopolymer coatings

“…Table S4 depicts that the recoveries of the spiked analytes were between 92.1 and 108.7% according to the proposed OT-CEC method. These results reveal that the OT-CEC assay using homopolymer PNAScoated capillaries performed better than other reported assays (Supporting Information Table S5) and has a high potential for application to the quantification of antipyretic analgesics drug concentrations in urinary samples [23].…”

Partial and Аpparent Мolar Volume of Аzithromycin in Its Solutions in Еthanol, 1-Рropanol, and 1-Butanol at 300.15, 305.15, 310.15 K and Ambient Pressure

“…The presence of hydrogen bonds in polar solvents has a significant effect on the dielectric, physicochemical and acoustic properties of mixtures. Alcohols are widely used as solvents in chemical and pharmaceutical industries, during extraction [6][7][8], as dispersing agents for nanomaterials [9][10][11][12] and for the synthesis of other organic compounds [13][14][15][16]. A large number of studies devoted to alcohols and their mixtures at various temperatures and pressures have been carried out using densimetry, viscometry, spectroscopy, and computer chemistry [17][18][19][20][21][22][23][24][25][26][27][28][29].…”

Preparation of open‐tubular CEC column bonded with 6‐O‐monotosyl‐deoxy‐β‐cyclodextrin and its application in the enantioseparation of several related benzimidazoles

“…The intermediates with high chemical stability can be obtained by replacing active hydrogen in organic compounds with silane protecting agents, meanwhile, the reactivity of other functional groups in molecules is not affected [16–18]. Then, the protected active hydrogen is recovered by catalytic hydrolysis or alcoholysis, simultaneously removing silyl alkyl without affecting other groups of the molecule, so as to synthesize a series of specific compounds [19–21]. Silanating agents are widely used in CE due to the high conversion in silane of protection, deprotection, and even quantitative reaction [22,23].…”