Extraction Equilibria of Cephalosporin Antibiotics with Aliquat-33

Abstract

The extraction equilibria of Cephalosporin antibiotics with Aliquat-336 (tricaprylylmethylammonium chloride) in various solvents were studied at pH values above the pK a2 values of the antibiotics. The reactive extraction, which is essentially an anion-exchange reaction, takes place in a 1:1 stoichiometry. The extraction equilibrium constants (K P ) could be correlated well with the hydrophobicity scale of the antibiotics. The equilibrium constants for coextraction of the buffer ions were found to be lower than those of the cephalosporin antibiotics, indicating the possibility of exploiting the reactive extraction technique for process application. The K P values obtained for a specific solute were also found to correlate well with the dipole moment of the solvents.

Optimization of rosmarinic acid extraction from lemon balm (Melissa officinalis)

“…Dependence of isolated compound yields on theoretical dielectric constant of extraction solvent is well-know from literature. Similar course of this dependence was observed at various natural compounds such as antibiotics (BORA and DUTTA, 2000) or pigments from paprika (KISS et al, 2000).…”

Extraction of Cephalosporin Antibiotics with Aqueous Two-phase Systems Composed of Water-miscible Organic Solvents and Salts

“…From the view-points of highest distribution ratio and lowest water content in the top phase, THF is considered to be a suitable solvent in this study. Previously, the distribution ratios of cephalexin were reported to be 3.2 for an ATPS consisting of PEG400 (20.0% w/w) and ammonium sulfate (17.5% w/w) without additives [9] and 0.9 for solvent extraction with Aliquat 336 [6]. In this work, the highest distribution ratio (= 3.13) is obtained with an ATPS consisting of THF (42.5% w/w) and K 2 HPO 4 (9.6% w/w) and this value was comparable with values reported previously.…”

“…However, solvent extraction of cephalosporin C, which is representative of -lactam antibiotics, was difficult due to its hydrophilicity. Therefore, reactive extraction [5,6], liquid membrane [7] and aqueous two-phase systems (ATPS) [8][9][10][11][12] have been studied for recovery of cephalosporin antibiotics.…”

Determination of Anti‐Parkinson Drug Pramipexole Using a Label‐free Biosensor and Evaluation of its Interaction with ds‐DNA

“…One of such techniques is electrochemical methods owing to their unique properties like miniaturization, high sensitivity, rapidity, simplicity and reliability [12–15]. Today, electrochemical DNA sensors can be involved in determining certain biochemical processes in the fields of medicine, pharmacy, and food quality assessment [16–22]. However, more attention has been paid to the development of these biosensors for activities such as screening for DNA damage and interaction of DNA and drugs.…”