Extraction, characterization of aloe polysaccharides and the in-depth analysis of its prebiotic effects on mice gut microbiota

Liu, Chang; Du, Peng; Guo, Yahui; Xie, Yunfei; Yu, Hang; Yao, Weirong; Cheng, Yuliang; Qian, He

doi:10.1016/j.carbpol.2021.117874

Cited by 60 publications

(18 citation statements)

References 46 publications

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“…In order to minimize the decomposition of polysaccharides under high temperature, Liu et al analyzed the optimal ultrasonic extraction conditions without reducing the activity of the compounds. The optimal conditions were found to be under ultrasound at 500 W, at 70 • C for 60 min [207].…”

Section: Aloe Veramentioning

confidence: 99%

The Renaissance of Plant Mucilage in Health Promotion and Industrial Applications: A Review

et al. 2021

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Plant mucilage is a renewable and cost-effective source of plant-based compounds that are biologically active, biodegradable, biocompatible, nontoxic, and environmentally friendly. Until recently, plant mucilage has been of interest mostly for technological purposes. This review examined both its traditional uses and potential modern applications in a new generation of health-promoting foods, as well as in cosmetics and biomaterials. We explored the nutritional, phytochemical, and pharmacological richness of plant mucilage, with a particular focus on its biological activity. We also highlighted areas where more research is needed in order to understand the full commercial potential of plant mucilage.

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Section: Aloe Veramentioning

confidence: 99%

The Renaissance of Plant Mucilage in Health Promotion and Industrial Applications: A Review

et al. 2021

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“…After S100a9 antibody treatment, essential pathways related to CAC such as the cytokine-cytokine receptor interaction pathway are inhibited (Zhang X et al,2017). Fructose and mannose metabolism can improve the intestinal ora and regulate intestinal function (Liu C et al,2021). The destruction of the critical enzyme function of TGS is found in the "galactose metabolism" and "fructose and mannose metabolism" pathways, which are fructose kinase α-and β-galactosidase, which can cause the decomposition of TGS (Metzler-Zebeli BU et al, 2019& Jin M et al,2018.…”

Section: Discussionmentioning

confidence: 99%

Identification of molecular subgroups of ulcerative colitis by gene expression profile

Zhang

Feng

et al. 2021

Preprint

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Ulcerative colitis (UC) is a chronic inflammatory disease that is prone to recurrent attacks. It has complex pathogenesis, which is closely related to genetics, constitution, dietary habits, and environmental factors. From the comprehensive Gene Expression Omnibus database (GEO), we retrieved gene expression profiles and classified 197 cases of UC into three subgroups for the purpose of predicting the basic molecular characteristics for different types of ulcerative colitis. As expected, each group showed its own clinical peculiarity and way of presentation. In this article, consensus clustering was used to divide the sample into three. The WGCNA analysis was applied to evaluate specific modules and reveal transcriptional differences among the subgroups. Subsequently, pathway and function enrichment analysis was conducted based on WGCNA. In subgroup Ⅰ, fructose and mannose metabolism pathway and cell cycle 11/36 pathway are up-regulated, which could be an indicator of exacerbation. Furthermore, the hematopoietic cell lineage pathway, which was significantly up-regulated in subgroup Ⅱ, might be indicating a disease correlation. In subgroup Ⅲ, the gene expression pattern of the peroxisome pathway is similar to the normal group, which may indicate an early stage of UC. Although no significant prognostic difference existing among the groups, there were significant differences in their underlying biological characteristics. This suggests that transcriptome classifications also represent risk factors for different disease states and ages. In summary, the bioinformatics techniques used in this study contribute to identifying molecular subtypes for diagnosing human ulcerative colitis. The transcriptome classification of UC cases suggests that each subgroup may have its own gene expression pattern and pathway, providing further personalized treatment guidance for patients with ulcerative colitis.

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“…Rats were gavaged with AP and intraperitoneal injections of noggin once daily for 12 weeks. The dose of AP was chosen based on previous studies with minor modifications [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Aloe polysaccharide promotes osteogenesis potential of adipose-derived stromal cells via BMP-2/Smads and prevents ovariectomized-induced osteoporosis

et al. 2022

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Background Aloe polysaccharide (AP) is a type of an active macromolecule of Aloe vera, which contributes to its function. However, whether AP possesses anti-osteoporosis properties is unknown. Methods Adipose-derived stromal cells were treated with different concentrations of AP. Early and late osteogenesis were, respectively, evaluated by ALP and Alizarin Red S staining. The effect of AP on the processes of adipogenesis inhibition in ADSCs was analyzed by oil red O staining. Western blot was used to assess the expression of osteogenic and adipogenic related factors. Then, Noggin was administered to further confirm the mechanism by which AP promotes the osteogenesis of ADSCs. Finally, 40 female SD rats were classified into a bilateral laparotomy group (Sham group) and three bilateral ovariectomy groups: OVX group, OVX + AP group, and OVX + AP + Noggin group. The bilateral rat femurs were collected to perform micro-CT scanning, HE, Masson trichrome, and Oil red O staining. Results The results indicated that AP could increase ALP expression and calcium deposition. Through molecular mechanisms, AP promotes the protein expression of COL1A1, OPN, and ALP in ADSCs, but downregulates the expression of PPARγ. Also, AP directs ADSCs’ fate by stimulating the BMP2/Smads signaling pathway. In vivo, the rat AP-treated had more trabecular bone than the OVX rat, indicating partial protection from cancellous bone loss after treatment with AP. Conclusion Our results show that AP may promote osteogenesis of ADSCs through BMP-2/Smads signaling pathway and inhibits lipogenic differentiation. Thus, AP might be a promising alternative medicine to treat postmenopausal osteoporosis.

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Extraction, characterization of aloe polysaccharides and the in-depth analysis of its prebiotic effects on mice gut microbiota

Cited by 60 publications

References 46 publications

The Renaissance of Plant Mucilage in Health Promotion and Industrial Applications: A Review

The Renaissance of Plant Mucilage in Health Promotion and Industrial Applications: A Review

Identification of molecular subgroups of ulcerative colitis by gene expression profile

Aloe polysaccharide promotes osteogenesis potential of adipose-derived stromal cells via BMP-2/Smads and prevents ovariectomized-induced osteoporosis

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