Extraction and Properties of Black Rice Pigment

Tai, Linyu; Huang, Gangliang

doi:10.1007/s11094-021-02318-y

Cited by 2 publications

(1 citation statement)

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“…Fissitungfine B was extracted and separated from the tropical medicinal plant Fissistigma tungfangense (Figure 1, Tai & Huang, 2021). In vitro screening of anti-tumor activity, it was found to have a good activity and inhibitory activity against a variety of cell lines.…”

Section: Design and Synthesismentioning

confidence: 99%

Synthesis and anti‐tumor activity of Fissitungfine B compounds

Zhou

Huang

2022

Chem Biol Drug Des

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In order to explore the potential anti-tumor activity functional molecules, a series of Fissitungfine B derivatives were designed and synthesized. Their anti-tumor activity effects on Hela, MCF-7 and A-549 cell lines were evaluated in vitro. The results showed that some of these Fissitungfine B derivatives exhibited moderate to good anti-tumor activities. Especially, compound 4 g with the highest inhibitory activities against all tested cell lines with the Hela was IC 50 = 3.82 ± 0.56 μM, MCF-7 was IC 50 = 5.53 ± 0.68 μM, and A-549 was IC 50 = 4.55 ± 0.53 μM.Furthermore, the compounds 4 g have higher inhibitory effects on TDP2 in vitro.In vivo, the biological activities assay results showed that the target compound 4 g had a good inhibitory effect on tumor growth. The target compound 4 g could inhibit tumor growth well, which might be use as a candidate drug or lead compound for further research and development anti-tumor agents.

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Section: Design and Synthesismentioning

confidence: 99%