Extraction and Isolation of Kaempferol Glycosides from the Leaves and Twigs of Lindera neesiana

Adhikari‐Devkota, Anjana; Dirar, Amina Ibrahim; Kurizaki, Ayumi; Tsushiro, Kazuki; Devkota, Hari Prasad

doi:10.3390/separations6010010

Cited by 9 publications

(7 citation statements)

References 20 publications

(25 reference statements)

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“…In our previous study [ 38 ], we reported the antioxidant potential of ethanolic and aqueous extracts of L. neesiana stems with IC 50 values of 175.32 and 187.91 μ g/mL, respectively. Similarly, Adhikari-Devkota et al [ 46 ] reported the antioxidant activity of 60% ethanolic extract of leaves and twigs of L. neesiana with an IC 50 value of 29.5 ± 1.04 μ g/mL. Sharma and Kumar [ 40 ] revealed the antioxidant potential of the methanolic extract of M. malabathricum with an IC 50 value of 21.86 ± 0.625 μ g/mL.…”

Section: Resultsmentioning

confidence: 98%

“…Although a number of studies [ 38 , 40 , 46 – 49 ] have been carried out demonstrating the antioxidant potential of various parts of the studied plant using different extraction solvents, the study on the antioxidant potential of 70% ethanolic extract of a selected part of the studied plant samples from Nepal has not been performed yet. In our previous study [ 38 ], we reported the antioxidant potential of ethanolic and aqueous extracts of L. neesiana stems with IC 50 values of 175.32 and 187.91 μ g/mL, respectively.…”

Section: Resultsmentioning

confidence: 99%

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Reducing Sugar, Total Phenolic Content, and Antioxidant Potential of Nepalese Plants

Khatri

Chhetri

2020

BioMed Research International

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The aim of the present study was to investigate the reducing sugar, total phenolic content, and in vitro antioxidant activity of 70% ( v / v ) ethanolic extract of seven medicinal plants grown in Nepal. The reducing sugar content and total phenolic content were determined by 3,5-dinitrosalicylic acid (DNSA) and the Folin–Ciocalteu method, respectively. The in vitro antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The reducing sugar content of the studied plant samples ranged from 6.89 ± 2.44 to 674.13 ± 2.43 mg GE/g dry extract weight and the total phenolic content ranged from 14.87 ± 0.41 to 281.71 ± 1.47 mg GAE/g dry extract weight. The reducing sugar and total phenolic content were found highest in Ficus glaberrima. Antioxidant activity was found highest in Melastoma malabathricum (IC50 value = 6.27 μg/mL), followed by F. glaberrima (IC50 value = 11.7 μg/mL). A positive and significant correlation was found between (i) total phenolic content and reducing sugar content and (ii) total phenolic content and antioxidant activity. The present study is the first study for the analysis of reducing sugar content of selected plants and for the scientific exploration of F. glaberrima. The present result suggests that the various parts of these studied plants could be assumed as a rich source of biologically active compounds and considered beneficial for the food and pharmaceutical industries.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Reducing Sugar, Total Phenolic Content, and Antioxidant Potential of Nepalese Plants

Khatri

Chhetri

2020

BioMed Research International

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“…Treatment with both water and EtOH extract of LN was found to reduce the production of NO, pro-inflammatory cytokines and iNOS and COX-2 production in lipopolysaccharide (LPS)-stimulated BV-2 cells. 3-O-α-rhamnopyranoside-isolated from 60% EtOH extract of LN leaves and twigs showed moderate scavenging activities on DPPH radicals and potent pancreatic lipase inhibitory activity [40]. These findings suggest that LN is a rich source of potent antioxidants, which show neuroprotection and anti-inflammatory activity.…”

Section: Genus Lindera and Antioxidant Properties Of Its Plantsmentioning

confidence: 85%

“…The water extract of LN fruit increased the secretion of Nrf-2 in N2a cells and inhibited LDH release in H 2 O 2 -stimulated BV-2 cells [ 39 ]. In another study, five kaempferol glycosides—kaempferol 3-O-β-glucopyranosyl(1 2)-[α-rhamnopyranosyl-(1 6)]-β-glucopyranoside-7-O-α-rhamnopyranoside, kaempferol 3-O-sophoroside, kaempferol 3-O-β-glucopyranosyl-(1 2)-[α-rhamnopyranosyl (1 6)]-β-glucopyranoside, kaempferol 3-O-β-glucopyranosyl(1 2)-α-rhamnopyranoside-7-O-α-rhamnopyranoside, and kaempferol 3-O-α-rhamnopyranoside—isolated from 60% EtOH extract of LN leaves and twigs showed moderate scavenging activities on DPPH radicals and potent pancreatic lipase inhibitory activity [ 40 ]. These findings suggest that LN is a rich source of potent antioxidants, which show neuroprotection and anti-inflammatory activity.…”

Section: Genus Lindera and Antioxidant Propertimentioning

confidence: 99%

Therapeutic Potential of Lindera obtusiloba: Focus on Antioxidative and Pharmacological Properties

Haque

Azam

Balakrishnan

et al. 2020

Plants

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Lindera obtusiloba (LO) BLUME from the genus Lindera (Lauraceae) is a medicinal herb traditionally used in Southeast Asian countries. Indigenously, extracts of different parts of the plant have been used to improve blood circulation and treat allergy, inflammation, rheumatism, and liver diseases. LO is a rich source of therapeutically beneficial antioxidative phytochemicals, such as flavonoids, butenolides, lignans and neolignans. Moreover, recent studies have unravelled the pharmacological properties of several newly found active constituents of LO, such as anti-inflammatory antioxidants (+)-syringaresinol, linderin A, anti-atherosclerotic antioxidant (+)-episesamin, anti-melanogenic antioxidants quercitrin and afzelin, cytotoxic 2-(1-methoxy-11-dodecenyl)-penta-2,4-dien-4-olide, (2Z,3S,4S)-2-(11-dodecenylidene)-3-hydroxy-4-methyl butanolide, anti-allergic koaburaside, (6-hydroxyphenyl)-1-O-beta-d-glucopyranoside and 2,6-dimethoxy-4-hydroxyphenyl-1-O-beta-d-glucopyranoside and the antiplatelet-activity compound Secolincomolide A. These findings demonstrate that LO can be a potential source of antioxidants and other prospective therapeutically active constituents that can lead to the development of oxidative stress-mediated diseases, such as cardiovascular disorders, neurodegenerative disorders, allergies, inflammation, hepatotoxicity, and cancer. Here, the antioxidant properties of different species of Lindera genus are discussed briefly. The traditional use, phytochemistry, antioxidative and pharmacological properties of LO are also considered to help researchers screen potential lead compounds and design and develop future therapeutic agents to treat oxidative stress-mediated disorders.

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“…Quercetin derivatives, such as glycosides, are present in different plant-derived food foodtuffs like tea, wine, onions, apples, and broccoli, and can prevent and treat non-infectious chronic diseases, such as diabetes, obesity, and hyperlipidemia [20,21]. Kaempferol glycosides also display interesting biological properties, including cytotoxicity toward human cancer cells, free radical scavenging activity, and inhibition of pancreatic lipase [22]. Quercetin and its derivatives, including quercetin-3-O-rhamnoside, were previously identified in aerial parts of sea rocket [3,19].…”

Section: Chemical Composition Of the Extracts: Qualitative Profilingmentioning

confidence: 99%

Phenolic Profile, Toxicity, Enzyme Inhibition, In Silico Studies, and Antioxidant Properties of Cakile maritima Scop. (Brassicaceae) from Southern Portugal

Placines

Castañeda-Loaiza

Rodrigues

et al. 2020

Plants

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Cakile maritima Scop. (sea rocket) is an edible halophyte plant with several ethnomedicinal uses. This work reports the chemical profile and bioactivities of food grade extracts from sea rocket organs. Toxicity was determined on mammalian cells, and phenolic profiling and the quantitation of the main metabolites were made by high-performance liquid chromatography coupled to mass spectrometry (HPLC-MS). Enzymatic inhibition was determined towards acetyl- and butyrylcholinesterase (AChE, BuChE), α-glucosidase, α-amylase, and tyrosinase. Docking studies were performed to tyrosinase, on the major metabolites, and samples were tested for antioxidant properties. Extracts were not toxic, were constituted mainly by flavonoids, and some compounds (roseoside and oleuropein) are here described for the first time in the species. The aerial organs’ ethanol extract had relevant activity towards 2,2-diphenyl-1-picrylhydrazyl [DPPH, half maximal inhibitory concentration (IC50) = 0.59 mg/mL], and ferric-reducing activity power (FRAP, IC50 = 0.99 mg/mL). All samples were more active towards AChE than on BuChE. The ethanol fruits’ extract inhibited α-glucosidase [2.19 mmol of equivalent of acarbose (ACAE)/g]. Samples were active against tyrosinase, especially the aerial organs’ ethanol extracts [25.9 mg of equivalent of kojic acid (KAE)/g]. Quercetin and kaempferol glycosides fit well into the enzymatic pocket of tyrosinase. Our results suggest sea rocket as a candidate to be further explored as a source of bioactive products.

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Extraction and Isolation of Kaempferol Glycosides from the Leaves and Twigs of Lindera neesiana

Cited by 9 publications

References 20 publications

Reducing Sugar, Total Phenolic Content, and Antioxidant Potential of Nepalese Plants

Reducing Sugar, Total Phenolic Content, and Antioxidant Potential of Nepalese Plants

Therapeutic Potential of Lindera obtusiloba: Focus on Antioxidative and Pharmacological Properties

Phenolic Profile, Toxicity, Enzyme Inhibition, In Silico Studies, and Antioxidant Properties of Cakile maritima Scop. (Brassicaceae) from Southern Portugal

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