Extractable and Non-Extractable Antioxidants Composition in the eBASIS Database: A Key Tool for Dietary Assessment in Human Health and Disease Research

Abstract

The antioxidant properties of foods are crucial in nutrition, food chemistry, and medicine studies but are often underestimated, with significant amounts of bioactive compounds containing physiological and biochemical properties remaining in the residue from extraction as non-extractable antioxidants. Over the last decade, extractable and non-extractable compounds have become key in the evaluation/determination of the antioxidant properties of food matrices because of their relevance in human health. This has led to the need to include extractable and non-extractable antioxidants in comprehensive and harmonized food composition databases for a wide range of applications within research, food, pharmaceutical, nutraceutical, and cosmeceutical areas. Additionally, the databases are invaluable as part of the health claims application process. eBASIS, (Bioactive Substances in Food Information System) a comprehensive database containing quality-evaluated scientific data, covering the composition of bioactive compounds present in foods, has flexible structures, allowing it to be extended to include newly emerging data on extractable and non-extractable compounds. Search criteria were developed and defined for compiling suitable peer-reviewed literature. Data quality assessment methods were established for the addition of composition data and antioxidant activity, with a focus on various parameters including: the extraction procedure, the antioxidant measurements, the expression of results. A total of 437 quality-evaluated datapoints on the composition of extractable and/or non-extractable compounds were entered into the database. This database update represents one of the first examples of building a database dedicated to antioxidant properties. This expansion of eBASIS provides a novel and unique tool for nutritionists, dietitians, researchers to use for a wide range of applications, such as dietary assessment, exposure studies and epidemiological studies, and may contribute to an increase in high-bioactive food consumption by consumers.

Food Composition Data and Tools Online and Their Use in Research and Policy: EuroFIR AISBL Contribution in 2022

“…The eBASIS-Creme Global exposure tool enables users to assess compound intakes from various foods across populations to determine whether compounds required to obtain a claimed effect can be reasonably consumed within a balanced diet [72]. In 2018, an update on extractable and non-extractable antioxidants was completed [73] with the addition of 437 quality-evaluated datapoints. This update was the first example of building a resource dedicated to antioxidant properties within the existing resource.…”

Antioxidant Properties of Bee Products Derived from Medicinal Plants as Beekeeping Sources

“…The inclusion of extractable and non-extractable compounds in current comprehensive and harmonized databases have been developed in the eBASIS BioActive Substances in Food Information System [93][94][95]. The development of search protocols and data collection systems have allowed to obtain new quality evaluated data on extractable and non-extractable antioxidants, used for the expansion eBASIS, leading thus, to a valuable unique data resource [96]. A total of 437 datapoints on the composition of extractable and/or non-extractable compounds were added into the database.…”

“…This update of eBASIS can be viewed as the first examples of building a database dedicated to antioxidant properties. This eBASIS 'expansion provides a new and unique tool for dietitians, nutritionists, and researchers for a great range of uses, e.g., dietary assessment, epidemiological studies, and exposure studies [96].…”

Dietary Antioxidants and Metabolic Diseases

“…A current challenge is given by combing through databases, repositories, and infrastructures to link information and compositive data on antioxidant to metabolomic pathways and biomarkers from the perspective of interoperability [17][18][19]. This Special Issue is focused on recent advances in the study of the health benefits of dietary antioxidants in metabolic diseases as well as on the discovery of novel molecular therapeutic mechanisms and the testing of novel targeted therapies.…”

“…A current challenge is given by combing through databases, repositories, and infrastructures to link information and compositive data on antioxidant to metabolomic pathways and biomarkers from the perspective of interoperability [17][18][19].…”