Extractability, selectivity, and comprehensiveness in supercritical fluid extraction of seaweed using ternary mixtures of carbon dioxide, ethanol, and water

Comprehensive two-step supercritical fluid extraction for green isolation of volatiles and phenolic compounds from plant material

“…2,8,9 It should be emphasized, that selectivity in this regard implies the ability of the extraction method to discriminate against defined unwanted interferences. 10 Recently, it has been demonstrated that the amount of cosolvent in CO 2 can be increased by more than 20%, resulting in a gas-expanded liquid with different physicochemical properties compared to the liquid state of the organic solvent. The formation of a single-phase liquid must be observed to avoid phase separation and poor extraction repeatability.…”

Improving and measuring the solubility of favipiravir and montelukast in SC-CO2 with ethanol projecting their nanonization

“…42 Huang et al have also improved the aspirin solubility in SC-CO 2 by five times by incorporating acetone as a cosolvent. 43 Particularly, ethanol has been one of the most commonly used polar cosolvents for the solute processing (drugs and nutraceuticals) 44–46 and for the extraction of bioactive substances from plant materials 47–49 due to its high solubility in SC-CO 2 at moderate pressure and temperatures, low toxicity and capacity to interact with polar solutes by hydrogen bonding.…”