Extract of Yi Zhi Fang improves learning and memory behaviours of mice and its possible mechanisms

Abstract

The effects of Yi Zhi Fang extract (YZF) on learning and memory performances were investigated in mice using passive avoidance tasks. Oral administration of YZF improved learning and memory disorders induced by chemicals in both normal and senile mice. The acetylcholine (Ach) concentration, the muscarinic Ach receptors (M-R) and the monoamine oxidase B (MAO-B) activities were analysed by a radioimmunoassay, a radioligand receptor binding assay and UV spectrophotometry, respectively, using senile decapitated mice. The oral administration of YZF to the senile mice increased the M-R concentration, while the concentration of Ach and the activity of MAO-B decreased in senile mice brains. From these results it is evident that YZF promotes the function of the central cholinergic system and inhibits the activity of MAO-B in mice brains resulting in an enhancement of learning and memory.

Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders

“…The mixed herbal preparations that have antidementia effects on animal models are listed: BR-16A (Mentat) (Faruqi et al, 1995;Handu and Bhargava, 1997), Bu-Zhong-Yi-Qi-Tang (Shih et al, 2000), Choto-san (Mizushima et al, 2003;Watanabe et al, 2003;Yuzurihara et al, 1999), DX-9386 (Nishiyama et al, 1994a(Nishiyama et al, , 1994bSmriga et al, 1995;Zhang et al, 1994), Liuwei-Dihuang-Wan (Hirokawa et al, 1994;Hsieh et al, 2003;Wei, 2000), Ninjin-yoei-to (Ren-Shen-Yang-Rong-Tang) (Egashira et al, 2003), Oren-gedoku-to (Huang-Lian-Jie-Du-Tang) (Xu et al, 2000), S-113M (Nishiyama et al, 1995b(Nishiyama et al, , 1996, Shosaikoto (Amagaya et al, 1990), Yi-Zhi-Fang (Shan et al, 2002), and Zingicomb (Topic et al, 2002a(Topic et al, , 2002b.…”

Changes in Paraoxonase, β-Glucosidase, and Carbonic Anhydrase Enzymes Related to Age and Scopolamine-Induced Memory Impairment in Rats

“…Sci. 2024, 14, 2582 2 of 10 peroxidation yields malondialdehyde (MDA) and antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) are thought to be crucial in combating oxidative stress [8][9][10][11][12]. Although many enzymes related to oxidative stress in NDs have been studied, Paraoxonase (PON), Carbonic Anhydrase (CA), and β-glucosidase enzymes are within the scope of our study.…”

Surrogate based accurate quantification of endogenous acetylcholine in murine brain by hydrophilic interaction liquid chromatography–tandem mass spectrometry

“…Since ACh is neither UV-active, fluorescent, nor electroactive, many assays including bioassays [5], radiochemical methods [6,7], or derivatization methods [8,9] have often been employed. For these methods with inherently complicated procedures and difficulties in quantitation, nowadays, high performance liquid chromatography with electrochemical detection (HPLC-ECD) [10][11][12] or electrospray-mass spectrometric detection (ESI-MS) [13][14][15] was frequently used to analyze of ACh in biological specimens.…”