Extract of pre-germinated brown rice protects against cardiovascular dysfunction by reducing levels of inflammation and free radicals in a rat model of type II diabetes

Liang, Huei‐Lung; Cheng, Pei‐Wen; Lin, Hui‐Li; Hao, Chi-Long; Ke, Liang‐Yin; Chou, Huei-Yin; Tseng, Yi-Hsiung; Yen, Hsueh‐Wei; Shen, Kuo‐Ping

doi:10.1016/j.jff.2020.104218

Cited by 7 publications

(6 citation statements)

References 57 publications

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“…Following our previous reports,‍ ( 11 – 13 ) this study we further proved PGBR that possessed the effects of treating NAFLD and its’ related complications in animal model induced by high fructose and high fat ingestion. PGBR decreased the metabolism of fructose, the synthesis of fatty acid and inhibited the inflammation in liver and heart, ameliorated the weight gains of liver and heart, higher blood pressure, and heart rate, liver index (GOT and GPT), cardiac fibrosis and hypertrophy.…”

Section: Discussionsupporting

confidence: 73%

“…After treatment with PGBR, those proteins, including COX-2, were obviously improved, and the cardiac dysfunctions were reversed evidently. PGBR could improve cardiovascular dysfunction induced by DM and NAFLD through inhibiting MAPKs and NF-κB pathway,‍ ( 11 – 13 ) and then decreasing the related proteins of cardiac hypertrophy and fibrosis ( Fig. 3 and 4 ).…”

Section: Discussionmentioning

confidence: 99%

“…According to our previous researches, pre-germinated brown rice (PGBR) contains rich dietary fiber and antioxidants that improves insulin activity, the glucose and lipids metabolism, lipids absorption, and inflammation. We have proved PGBR can treat metabolic syndrome, DM and their cardiovascular complications.‍ ( 11 – 13 ) To data, there are few studies to investigate the effects of PGBR on NAFLD. In this study, Wistar-Kyoto (WKY) rats were fed 10% high fructose water (HFW) and HFD to induce NAFLD, or fed HFW and HFD, in which the carboxyhydrate of HFD were replaced by PGBR for treatment.…”

Section: Introductionmentioning

confidence: 99%

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Pre-germinated brown rice alleviates non-alcoholic fatty liver disease induced by high fructose and high fat intake in rat

Cheng

Liang

Lin

et al. 2022

J. Clin. Biochem. Nutr.

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In past researches, we had been proved the action mechanism of pre-germinated brown rice (PGBR) to treat metabolic syndrome and diabetes mellitus. This study was to investigate the protective effect of PGBR in high fructose and high fat-induced non-alcoholic fatty liver disease (NAFLD) in rodents. WKY rats were divided into: Control group was fed normal drinking water and diet; FLD group was fed 10% high-fructose-water (HFW) and high-fat-diet (HFD); PGBR group was given HFW, and HFD mixed PGBR. After four weeks, the body, hepatic and cardiac weight gains of FLD group had significant increases than that of Control group. The enhanced blood pressure and heart rate, hypertriglyceridemia, hyperuricemia, and higher liver function index (GPT levels) were observed; meanwhile, the IL-6 and TNF-α levels of serum, and TG level of liver were also elevated in FLD group. The related protein expressions of lipid synthesis, inflammation, cardiac fibrosis, and hypertrophy were deteriorated by HFW/HFD. However, in treatment group, PGBR decreased all above influenced parameters, additionally GOT; and related protein expressions. PGBR treated HFW/HFD-induced NAFLD and cardiac complications might be via improving lipid homeostasis, and inhibiting inflammation. Together, PGBR could be used as a healthy food for controlling NAFLD and its’ cardiac dysfunction.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pre-germinated brown rice alleviates non-alcoholic fatty liver disease induced by high fructose and high fat intake in rat

Cheng

Liang

Lin

et al. 2022

J. Clin. Biochem. Nutr.

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“…Regulation of pro-inflammatory cytokines in the intestinal mucosa may alleviate gut dysfunction due to weaning stress ( Liu et al, 2008 ). The outer bran layers in brown rice contain bioactive compounds, including phenolic compounds such as isoferulic, p -coumaric, vanillic, and ferulic acid ( Pang et al, 2018 ), which enhance antioxidant activity and immune status ( Wu et al, 2013a ; Liang et al, 2020 ). In another study, a brown rice and rice bran-supplemented diet reduced liver inflammation and fibrosis in rats ( Wunjuntuk et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, brown rice is cheaper to process than white rice ( Saleh et al, 2019 ), and brown rice byproducts are also relatively cheaper in price than corn ( Piao et al, 2002 ). The bioactive compounds such as phenolic acids, flavonoids, aminobutyric acid, γ-oryzanol, α-tocopherol, and γ-tocotrienol in brown rice have beneficial effects on immune functions and gut health ( Pluske et al, 2003 ; Wu et al, 2013a ; Saleh et al, 2019 ; Liang et al, 2020 ). Due to these properties, brown rice can potentially replace corn in swine diets without negatively affecting growth performance, nutrient digestibility, and gut health.…”

Section: Introductionmentioning

confidence: 99%

Potential use of ground brown rice for weanling pigs

Lee

Kim

Cho

et al. 2021

Journal of Animal Science

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The current study was to assess the effects of substituting corn with ground brown rice (GBR) on growth performance, immune status, and gut microbiota in weanling pigs. Seventy-two weanling pigs [28-day-old with 6.78 ± 0.94 kg body weight (BW)] were randomly allotted to 2 dietary treatments with 6 pens and 6 pigs (3 barrows and gilts) per pen with in a randomized complete block design. The control pigs were fed a typical diet for weanling pigs based on corn and soybean meal diet (control diet: CON), and the other pigs were fed a diet formulated by replacing corn with GBR for 35 days. Growth performance, immune status, and gut microbiota of weanling pigs were measured. The substitution of corn with GBR did not affect growth performance or diarrhea frequency. Additionally, there were no differences in white blood cell number, hematocrit, cortisol, C-reactive protein, serum TNF-α levels between pigs fed CON or GBR for the first 2 weeks after weaning. However, weanling pigs fed GBR had lower (P < 0.05) serum TGF-β1 level than those fed CON. Furthermore, weanling pigs fed GBR had increased (P < 0.05) relative abundance of phylum Firmicutes and genus Lactobacillus and Streptococcus and decreased (P < 0.05) relative abundance of phylum Bacteroidetes and genus Clostridium and Prevotella in the gut microbiota compared with those fed CON. In conclusion, there was no significant difference in growth performance when corn was replaced with GBR in diets for weanling pigs. Furthermore, the substitution of corn with GBR in weaning diet modulated immune status and gut microbiota of pigs by increasing beneficial microbial communities and reducing harmful microbial communities. Overall, GBR-based diet is a potentially alternative to corn-based diet without negative effects on growth performance, immune status and gut microbiota changes of weanling pigs.

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Germinated Rice in Diabetes Management: Technological and Functional Changes

John,

Raman

2024

Starch Stärke

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Cereals are known for their outstanding source of macro‐ and micro‐nutrients and phytochemicals. However, their interactions within the food matrices result in complexes that interfere with bioavailability, bio‐accessibility, and its metabolism in the human system. Germination has been reported to interfere with these interactions in the food matrices and enhance the accessibility and digestibility of nutrients. The germinated rice in the management of the diabetes is a novel concept as it modulates the glycemic index of the product and also enhances the bio‐accessibility of phytochemicals. Type‐2 diabetes has shown an alarming increase in recent past, which is chiefly due to dietary habits and sedentary life style. Even though, medical science is developing new therapeutical measures, preventing the risk of disease through dietary modulations may be more preferred. Germination also improves the texture, cooking, and eating quality of rice making it more tastier. During germination, the starchphytochemical interactions, delayed digestibility and physiological performances and glycemic control, can pave way to diabetes management in such cases. In view of these, the current review focuses on the starch and its interactions with phytochemicals, the bioavailability and bioaccessibility of these components, and their impact on reduced glycemic index.

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Extract of pre-germinated brown rice protects against cardiovascular dysfunction by reducing levels of inflammation and free radicals in a rat model of type II diabetes

Cited by 7 publications

References 57 publications

Pre-germinated brown rice alleviates non-alcoholic fatty liver disease induced by high fructose and high fat intake in rat

Pre-germinated brown rice alleviates non-alcoholic fatty liver disease induced by high fructose and high fat intake in rat

Potential use of ground brown rice for weanling pigs

Germinated Rice in Diabetes Management: Technological and Functional Changes

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