Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice

Fan, Shengjie; Zhang, Yu; Sun, Qiang; Yu, Longquan; Li, Mingxia; Zheng, Bin; Wu, Xuli; Yang, Baican; Li, Yiming

doi:10.1016/j.jnutbio.2014.02.010

Cited by 100 publications

(85 citation statements)

References 50 publications

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“…In this test, the blood glucose level in normal and MBBP-fed mice recovers the previous level in the normal range, but the blood glucose level is still high in diabetic mice, suggesting the treatment of MBBP would increase glucose tolerance. Insulin resistance is an early condition of metabolic disorders, which could lead to diabetes, hyperlipidemia, and steatosis [35]. For ITT, MBBP administration improved insulin sensitivity in the MBBP group mice, compared to the diabetic mice.…”

Section: Discussionmentioning

confidence: 99%

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

Yin

Liu

Zhang

2017

Food & Nutrition Research

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This experiment, based on the previous study on R. mori, introduces whole mulberry branch powder into the diet to treat diabetic mice. Mulberry branch bark powder (MBBP) was administered orally to streptozotocin (STZ)-induced type II diabetic (T2D) mice to investigate hypoglycemic effects. After a 4-week period of diet consumption containing 5%, 10% and 20% MBBP, the fasting blood glucose, body weight and the related western blotting were measured, pathologic and immunohistochemical were observed. The 20% MBBP group showed a significant reduction in hyperglycemia and hyperinsulinemia; fasting blood glucose and insulin decreased from 25.0 to 14.8 mmol/L and 26.5 to 16.0 mU/L, respectively. Pathologic and immunohistochemical observation showed that MBBP administration lead to the repair of pancreas cells and restoration of insulin secretion. Dietary MBBP was associated with the decrease in the contents of 3, 4-methylenedioxeamphetamine, 8-OHdG, aspartate aminotransferase, and alanine aminotransferase, and the increase in antioxidative ability and glucose tolerance. Western blotting (WB) analysis suggested that MBBP decreased the TNF-α levels, thus relieving inflammation and improving liver function. It also led to the downregulation of apoptosis factor expression. WB also confirmed that MBBP enhanced the gene expression of the key enzymes: insulin receptor, insulin receptor substrate, p-AKT, GSK3β, glycogen synthase, G6Pase and phosphoenolpyruvate carboxykinase, which are related to glucose metabolism in the liver, and increase the expression of the genes PDX-1, GLUT2, MafA, and glucokinase, related to insulin secretion. Thus, oral administration of MBBP regulated insulin secretion and effectively maintained normal levels of glucose metabolism in mice, which may be done by improving the antioxidant capacity and activating insulin signaling with T2D..

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Section: Discussionmentioning

confidence: 99%

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

Yin

Liu

Zhang

2017

Food & Nutrition Research

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“…no. d12492; research diets, inc.) for 3 months to induce obesity (31). The HFd-fed mice were distributed into two groups of five mice and housed in cages to permit control of their food intake and body weight.…”

Section: Methodsmentioning

confidence: 99%

Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling

Yao

2020

Mol Med Report

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obesity has been increasing globally for over three decades. according to previous studies, dietary obesity is usually associated with endoplasmic reticulum stress (erS) and STaT3 signaling, which result in interference with the homeostatic control of energy and lipid metabolism. Ginsenosides (GS) administered to mice will modulate adiposity and food intake; however, the mechanism of food inhibition is unknown. The aim of the present study was to investigate whether GS may inhibit erS and regulate STaT3 phosphorylation in GT1-7 cells (a mouse hypothalamus gonadotropin-releasing hormone neuron cell line) and the hypothalamus in order to reduce the body weight and ameliorate hepatic steatosis in high fat diet (HFd)-induced obese mice. in the present study, GS inhibited the appetite, reduced the body weight, visceral fat, body fat content and blood glucose, and ameliorated the glucose tolerance of the obese mice compared with HFd mice. in addition, the levels of aspartate aminotransferase and alanine aminotransferase, triglyceride (TG), leptin and insulin in the serum were reduced compared with HFd mice. There was less TG in the liver, but more in the feces compared with HFd mice. using hematoxylin and eosin staining of HepG2 cells and liver tissues, GS were demonstrated to improve the non-alcoholic fatty liver of the HFd-induced obese mice and reduce the diameter of the fat cells compared with HFd mice. GS also increased oxygen consumption and carbon dioxide emissions in the metabolic cage data compared with HFd mice. in the GT1-7 cells, GS alleviated the erS induced by tunicamycin and enhanced the activation of the STaT3 phosphorylation pathway. Furthermore the erS of the liver was relieved to achieve the aforementioned pharmacological effects. GS were used in the homeostatic control of the energy and lipid metabolism of a diet-induced obesity model. in conclusion, present studies suggest that GS exert these effects by increasing STaT3 phosphorylation expression and reducing the erS. Thus, GS reduce body weight and ameliorate hepatic steatosis in HFd-induced obese mice.

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“…Sabitha, Ramachandran, Naveen, and PanneerselvamSabitaet al, (2012, 2013) [58,59] has reported antidiabetic and antihyperlipidemic potential of okra peel and seed powder in streptozotocin (STZ)induced diabetic rats.…”

Section: Validated Pharmacological Properties Of the Okramentioning

confidence: 99%

Abundantly available cultigen Okra ,a clandestine natural therapeutic treasure trove :A brief overview

Pal

2020

Proceedings of MOL2NET 2020, International Conference on Multidisciplinary Sciences, 6th Edition

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Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice

Cited by 100 publications

References 50 publications

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling

Abundantly available cultigen Okra ,a clandestine natural therapeutic treasure trove :A brief overview

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