Extract of Ganoderma lucidum prolongs sleep time in rats

Cui, Xiang‐Yu; Cui, Shuzhen; Zhang, Juan; Wang, Zijun; Yu, Bin; Sheng, Zhiqiang; Zhang, Xueqiong; Zhang, Yonghe

doi:10.1016/j.jep.2011.12.020

Cited by 45 publications

(25 citation statements)

References 26 publications

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“…For example, the usage of G. lucidum for its An-Shen effect (tranquilising) was only recently supported with evidence from an animal model study (Cui et al, 2012) yet has been used for centuries for its tranquilising effect. This study showed that the administration of G. lucidum extract increased total sleep time and non-rapid eye movement significantly in rats, with a possible mechanism related to TNF-a (Cui et al, 2012). More evidence of this sort is required to appropriately support TCM claims about the health benefits of G. lucidum products.…”

Section: Applications As Nutraceuticalsmentioning

confidence: 99%

From 2000years of Ganoderma lucidum to recent developments in nutraceuticals

et al. 2015

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Section: Applications As Nutraceuticalsmentioning

confidence: 99%

From 2000years of Ganoderma lucidum to recent developments in nutraceuticals

et al. 2015

View full text Add to dashboard Cite

“…9 Several studies also show different result in different design. Ganoderma lucidum increases IL-10 level [10][11][12] increases TNF-α 13 and no correlation with IL-6 level in cancer patients. 14 But none of the previous studies focus on inflammatory aspect of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Polysaccharide Peptide: A promising Anti Inflammation and Anti Oxidant in Atherosclerosis

Prasetya

Ashriyah

Setyawati

et al. 2015

IJC

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Background : Heart disease is the leading cause of death for both men and women, but heart disease is preventable and controllable. Ganoderma lucidum is widely used as traditional medicine for centuries particularly in China, Japan, and Korea. Previous study showed antioxidative activity of polysaccharide peptide (PsP) from Genoderma lucidum.Objective : This study was aimed to evaluate anti-inflammatory and antioxidant effect of polysaccharide peptide (PsP) from Ganoderma lucidum in atherosclerotic rats.Methods : The atherosclerotic rats were randomly divided into four groups (5 rats each group) : atherosclerotic model with high-fat diet, low dose PsP treated group (50 mg/kgBW), medium dose PsP treated group (150 mg/kgBW), high dose PsP treated group (300 mg/kgBW), with normal mice used as a control group. Parameters measured were the level of MDA, SOD, IL - 6 , IL - 10, hsCRP, TNF - ?, lipid profile and foam cell.Results : After PsP therapy for 5 weeks, the levels of MDA (p=0.01), hsCRP (p=0.018) in rats model of atherosclerosis decrease significantly. PsSP can reduce levels of IL - 6 (p=0.933) and increase levels of SOD (p=0.28) descriptively at PsP doses 150 mg/kgBW. While the levels of TNF-? (p=0.894) and IL-10 (p=0.98) was not affected by administration of PsP. PsP improve the lipid profile by increasing HDL (p=0.002) and lowering total cholesterol (p=0.04). The formation of foam cells (p=0.024) as a marker of atherogenesis significantly decreased by administration of PsP .Conclusion : PSP can be useful to reduce inflammatory processes and oxidative stress to prevent the process of atherogenesis.

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“…Another five rats in each group underwent surgery 1 week prior to any PSD subjection or JTW intake, using standard procedures as bellow [25]. Under pentobarbital (50 mg/kg, intraperitoneal injection)-induced anesthesia, two stainless steel screws (2 mm long, 1.2 mm of diameter) attached to insulated wire were implanted in the skull over the frontal-parietal cortex for electroencephalographic (EEG) recordings.…”

Section: Methodsmentioning

confidence: 99%

The effects of Jiao-Tai-Wan on sleep, inflammation and insulin resistance in obesity-resistant rats with chronic partial sleep deprivation

Zou

Huang

et al. 2017

BMC Complement Altern Med

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BackgroundJiao-Tai-Wan (JTW), composed of Rhizome Coptidis and Cortex Cinnamomi, is a classical traditional Chinese prescription for treating insomnia. Several in vivo studies have concluded that JTW could exert its therapeutical effect in insomnia rats. However, the specific mechanism is still unclear. The present study aimed to explore the effect of JTW on sleep in obesity-resistant (OR) rats with chronic partial sleep deprivation (PSD) and to clarify its possible mechanism.MethodsJTW was prepared and the main components contained in the granules were identified by 3D-High Performance Liquid Chromatography (3D-HPLC) assay. The Male Sprague-Dawley (SD) rats underwent 4 h PSD by environmental noise and the treatment with low and high doses of JTW orally for 4 weeks, respectively. Then sleep structure was analyzed by electroencephalographic (EEG). Inflammation markers including high-sensitivity C reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were examined in the rat plasma. Meanwhile, metabolic parameters as body weight increase rate, fasting plasma glucose (FPG), fasting insulin (FINS) levels and insulin resistance index (HOMA-IR) were measured. The expressions of clock gene cryptochromes (Cry1 and Cry2) and inflammation gene nuclear factor-κB (NF-κB) in peripheral blood monocyte cells (PBMC) were also determined.ResultsThe result showed that the administration of JTW significantly increased total sleep time and total slow wave sleep (SWS) time in OR rats with PSD. Furthermore, the treatment with JTW reversed the increase in the markers of systemic inflammation and insulin resistance caused by sleep loss. These changes were also associated with the up-regulation of Cry1 mRNA and Cry 2 mRNA and the down-regulation of NF-κB mRNA expression in PBMC.ConclusionsThis study suggests that JTW has the beneficial effects of improving sleep, inflammation and insulin sensitivity. The mechanism appears to be related to the modulation of circadian clock and inflammation genes expressions in PBMC.

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Extract of Ganoderma lucidum prolongs sleep time in rats

Cited by 45 publications

References 26 publications

From 2000years of Ganoderma lucidum to recent developments in nutraceuticals

From 2000years of Ganoderma lucidum to recent developments in nutraceuticals

Polysaccharide Peptide: A promising Anti Inflammation and Anti Oxidant in Atherosclerosis

The effects of Jiao-Tai-Wan on sleep, inflammation and insulin resistance in obesity-resistant rats with chronic partial sleep deprivation

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