Extract of Aquilaria crassna leaves and mangiferin are vasodilators while showing no cytotoxicity

Wisutthathum, Sutthinee; Kamkaew, Natakorn; Inchan, Anjaree; Chatturong, Usana; Paracha, Tamkeen Urooj; Ingkaninan, Kornkanok; Wongwad, Eakkaluk; Chootip, Krongkarn

doi:10.1016/j.jtcme.2018.09.002

Cited by 13 publications

(7 citation statements)

References 25 publications

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“…Mangiferin's safety as well as its beneficial effect in improving cellular function was reported by several studies (Mei et al 2021b). The vascular protection effect of mangiferin in a range from 0.1 to 100 μM was proven without any cytotoxicity (Wisutthathum et al 2019). Also bone marrow erythrocytes showed no genotoxicity after oral application of 2 g/kg of mangiferin to NMRI mice (Rodeiro et al 2012).…”

Section: Toxicologymentioning

confidence: 89%

Recent Formulation Advances of Mangiferin

Barakat

Nasr

Ahmed

et al. 2022

Rev. Bras. Farmacogn.

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Nutraceuticals have recently gained interest owing to their valuable contribution in the treatment of several diseases, with high safety margin and low incidence of side effects. However, their efficacy is limited by some challenges, namely poor solubility, low permeability, and, consequently, low bioavailability. Delivery carriers have proven that they can overcome almost all the aforementioned limitations, leading to improvement in the pharmacological efficacy of nutraceuticals. Among the promising nutraceuticals that have currently evoked considerable interest is mangiferin from mango tree, which is a polyphenol exhibiting many favorable pharmacological actions, but unfortunately suffers from poor aqueous solubility and other limitations that lower its bioavailability and halter its efficacy. This review summarizes the pharmacological actions of mangiferin and provides an insight on how delivery carriers for mangiferin (lipidic, vesicular, polymeric, inorganic, and protein nanoparticles, as well as complexes) can overcome its pharmaceutical challenges, hence reflecting on its improved therapeutic effects in treatment of different diseases.

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Section: Toxicologymentioning

confidence: 89%

Recent Formulation Advances of Mangiferin

Barakat

Nasr

Ahmed

et al. 2022

Rev. Bras. Farmacogn.

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“…For cytotoxicity testing by the MTT assay, 26 cells were incubated with MTT reagent (0.5 mg/mL) for 4 h at 37 °C in CO 2 incubator. Then, the solution was discarded and DMSO (100 μL) was added and shaken for 15 min to dissolve formazan crystals.…”

Section: Methodsmentioning

confidence: 99%

Dried mulberry fruit ameliorates cardiovascular and liver histopathological changes in high-fat diet-induced hyperlipidemic mice

Chaiwong

Chatturong

Chanasong

et al. 2021

Journal of Traditional and Complementary Medicine

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Background and aim Metabolic disease encompasses most contemporary non-communicable diseases, especially cardiovascular and fatty liver disease. Mulberry fruits of Morus alba L. are a favoured food and a traditional medicine. While they are anti-atherosclerotic and reduce hyperlipidemic risk factors, studies need wider scope that include ameliorating cardiovascular and liver pathologies if they are to become clinically effective treatments. Therefore, the present study sought to show that freshly dried mulberry fruits (dMF) might counteract the metabolic/cardiovascular pathologies in mice made hyperlipidemic by high-fat diet (HF). Experimental procedure C57BL/6J mice were fed for 3 months with either: i) control diet, ii) HF, iii) HF+100 mg/kg dMF, or iv) HF+300 mg/kg dMF. Body weight gain, food intake, visceral fat accumulation, fasting blood glucose, plasma lipids, and aortic, heart, and liver histopathologies were evaluated. Adipocyte lipid accumulation, autophagy, and bile acid binding were also investigated. Results and conclusion HF increased food intake, body weight, visceral fat, plasma total cholesterol (TC) and low-density lipoprotein (LDL), TC/HDL ratio, blood glucose, aortic collagen, arterial and cardiac wall thickness, and liver lipid. Both dMF doses prevented hyperphagia, body weight gain, and visceral fat accumulation, lowered blood glucose, plasma TG and unfavourable TC/HDL and elevated plasma HDL beyond baseline. Arterial and cardiac wall hypertrophy, aortic collagen fibre accumulation and liver lipid deposition ameliorated in dMF-fed mice. Clinical trials on dMF are worthwhile but outcomes should be holistic commensurate with the constellation of disease risks. Here, dMF should supplement the switch to nutrient-rich from current energy-dense diets that are progressively crippling national health systems.

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“…In some experiments, endothelial cells were mechanically removed by gently rubbing the lumen with a stainless steel wire. The mesenteric rings were mounted on a pair of intraluminal wires in organ chambers containing physiological Krebs’ solution (mM): NaCl, 122; KCl, 5; [N-(2-hydroxyethyl) piperazine N’-(2-ethanesulfonic acid)] HEPES, 10; KH 2 PO 4 , 0.5; NaH 2 PO 4 , 0.5; MgCl 2 , 1; glucose, 11; and CaCl 2 , 1.8 (pH 7.3), at 37 °C and aerated [29,49,50,51]. The vessel segments were allowed to equilibrate for 1-h at a resting tension of 1–1.3 g during which the solution was replaced every 15 min.…”

Section: Methodsmentioning

confidence: 99%

Vasodilatory Effects and Mechanisms of Action of Bacopa monnieri Active Compounds on Rat Mesenteric Arteries

et al. 2019

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B. monnieri extract (BME) is an abundant source of bioactive compounds, including saponins and flavonoids known to produce vasodilation. However, it is unclear which components are the more effective vasodilators. The aim of this research was to investigate the vasorelaxant effects and mechanisms of action of saponins and flavonoids on rat isolated mesenteric arteries using the organ bath technique. The vasorelaxant mechanisms, including endothelial nitric oxide synthase (eNOS) pathway and calcium flux were examined. Saponins (bacoside A and bacopaside I), and flavonoids (luteolin and apigenin) at 0.1–100 µM caused vasorelaxation in a concentration-dependent manner. Luteolin and apigenin produced vasorelaxation in endothelial intact vessels with more efficacy (Emax 99.4 ± 0.7 and 95.3 ± 2.6%) and potency (EC50 4.35 ± 1.31 and 8.93 ± 3.33 µM) than bacoside A and bacopaside I (Emax 83.6 ± 2.9 and 79.9 ± 8.2%; EC50 10.8 ± 5.9 and 14.6 ± 5.4 µM). Pretreatment of endothelial intact rings, with L-NAME (100 µM); an eNOS inhibitor, or removal of the endothelium reduced the relaxant effects of all compounds. In K+-depolarised vessels suspended in Ca2+-free solution, these active compounds inhibited CaCl2-induced contraction in endothelial denuded arterial rings. Moreover, the active compounds attenuated transient contractions induced by 10 µM phenylephrine in Ca2+-free medium containing EGTA (1 mM). Thus, relaxant effects occurred in both endothelial intact and denuded vessels which signify actions through both endothelium and vascular smooth muscle cells. In conclusion, the flavonoids have about twice the potency of saponins as vasodilators. However, in the BME, there is ~20 × the amount of vaso-reactive saponins and thus are more effective.

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Extract of Aquilaria crassna leaves and mangiferin are vasodilators while showing no cytotoxicity

Cited by 13 publications

References 25 publications

Recent Formulation Advances of Mangiferin

Recent Formulation Advances of Mangiferin

Dried mulberry fruit ameliorates cardiovascular and liver histopathological changes in high-fat diet-induced hyperlipidemic mice

Vasodilatory Effects and Mechanisms of Action of Bacopa monnieri Active Compounds on Rat Mesenteric Arteries

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