Abstract:Single-molecule trajectories from nonequilibrium unfolding
experiments
are widely used to recover a biomolecule’s intrinsic free-energy
profile. Trajectories of molecular motors from similar single-molecule
experiments may be mapped to biased diffusion over an inclined free-energy
profile. Such an effective potential is not a static equilibrium property
anymore, and how it can benefit molecular motor study is unclear.
Here, we introduce a method to deduce this effective potential from
motor trajectories with r… Show more
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