Extract from Mimosa pigra attenuates chronic experimental pulmonary hypertension

Rakotomalala, G.; Agard, C.; Tonnerre, Pierre; Tesse, Angela; Derbré, Séverine; Michalet, Serge; Hamzaoui, J.; Rio, Marc; Cario‐Toumaniantz, Chrystelle; Richomme, Pascal; Charreau, Béatrice; Loirand, Gervaise; Pacaud, Pierre

doi:10.1016/j.jep.2013.03.075

Cited by 43 publications

(35 citation statements)

References 32 publications

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“…Although Mimosa pigra was shown to attenuate pulmonary hypertension (Rakotomalala et al, 2013), we report here the use of M. pigra in alleviating diarrhoea and STIs. Rakotomalala et al (2013) showed that M. pigra is rich in tryptophan, quercetin and several phenolic compounds which confer antioxidant and anti-inflammatory properties.…”

Section: Discussionmentioning

confidence: 75%

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Ethnomedicinal plants used by traditional healers in the management of HIV/AIDS opportunistic diseases in Rundu, Kavango East Region, Namibia

Chinsembu

Hijarunguru

Mbangu

2015

South African Journal of Botany

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Since human immunodeficiency virus (HIV) infected persons seek treatment from traditional healers, there is an urgent need to document plants used by traditional healers to manage acquired immunodeficiency syndrome (AIDS) opportunistic diseases. This study documented plants used to manage AIDS-related opportunistic diseases in Rundu, Kavango East Region, Namibia. Primary, secondary and tertiary samplings of traditional healers were conducted. During the interviews, the following ethnobotanical data were recorded: plant species, parts used, modes of preparation, administration, and diseases treated. Data were analysed by calculating percentage frequencies, familiarity index (F i ), and factor of informant consensus (F IC ). Seventy plant species from 54 genera and 28 families, mostly the Fabaceae, Anacardiaceae, and Combretaceae were used as ethnomedicines. Leaves, followed by roots and bark, were mostly harvested for the treatment of skin diseases, These multi-use plant species may have broad antimicrobial activities but also risk overexploitation. Further work is needed to screen plant extracts for in vitro anti-HIV activity and cytotoxicity.

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Section: Discussionmentioning

confidence: 75%

“…Rakotomalala et al (2013) showed that M. pigra is rich in tryptophan, quercetin and several phenolic compounds which confer antioxidant and anti-inflammatory properties. Hibiscus fuscus, also harvested as a remedy for diarrhoea in Katima Mulilo (Chinsembu and Hedimbi, 2010), is an anti-TB plant remedy in Uganda (Bunalema et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Ethnomedicinal plants used by traditional healers in the management of HIV/AIDS opportunistic diseases in Rundu, Kavango East Region, Namibia

Chinsembu

Hijarunguru

Mbangu

2015

South African Journal of Botany

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“…Quercetin (18), another widely studied flavonoid [86][87][88][89][90], has been assessed for the release of elastase that is the major product secreted by neutrophils, which are cells associated with the innate immune system. When stimulated, neutrophils release elastase, which is mainly responsible for degrading foreign proteins during phagocytosis.…”

Section: Chronic Obstructive Pulmonary Disease (Copd)mentioning

confidence: 99%

Structure-Activity Association of Flavonoids in Lung Diseases

et al. 2014

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Flavonoids are polyphenolic compounds classified into flavonols, flavones, flavanones, isoflavones, catechins, anthocyanidins, and chalcones according to their chemical structures. They are abundantly found in Nature and over 8,000 flavonoids have from different sources, mainly plant materials, have been described. Recently reports have shown the valuable effects of flavonoids as antiviral, anti-allergic, antiplatelet, antitumor, antioxidant, and anti-inflammatory agents and interest in these compounds has been increasing since they can be helpful to human health. Several mechanisms of action are involved in the biological properties of flavonoids such as free radical scavenging, transition metal ion chelation, activation of survival genes and signaling pathways, regulation of mitochondrial function and modulation of inflammatory responses. The anti-inflammatory effects of flavonoids have been described in a number of studies in the literature, but not frequently associated to respiratory disease. Thus, this review aims to discuss the effects of different flavonoids in the control of lung inflammation in some disorders such as asthma, lung emphysema and acute respiratory distress syndrome and the possible mechanisms of action, as well as establish some structure-activity relationships between this biological potential and chemical profile of these compounds.

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“…At present, the active allelochemicals of M. pigra have not yet been identified. However, RosadoVallado et al (2000) and Rakotomalala et al (2013) reported the presence of flavonoid, quinone, saponin, sterol, tannin and phenolic compounds in M. pigra. Khaliq et al (2011) recommended that allelochemicals are usually more effective at influencing the target in a mixture than as individual compounds and Jabran et al (2015) also suggested that allelopathic activity and allelopathic effects are often due to the synergistic activity of allelochemicals rather than to a single compound because of the diversity of allelochemicals in plants.…”

Section: Discussionmentioning

confidence: 98%

“…Phytochemical screenings of M. pigra showed the presence of flavonoid, quinone, saponin, sterol, tannin and phenolic compounds (Rosado-Vallado et al, 2000;Rakotomalala et al, 2013). Due to its potential for spread and the presence of specific phytochemicals, M. pigra could have allelopathic attributes.…”

Section: Introductionmentioning

confidence: 99%

Allelopathic Effects of Giant Sensitive Plant (Mimosa pigra) Leaf Powder on Germination and Growth of Popping Pod and Purslane

Koodkaew¹

2017

IJAB

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To cite this paper: Koodkaew, I. and R. Rottasa, 2017. Allelopathic effects of giant sensitive plant (Mimosa pigra) leaf powder on germination and growth of popping pod and purslane. AbstractThe most of invasive alien species possess allelopathic properties for beneficial success in site establishment. Giant sensitive plant (Mimosa pigra L.) is an important invasive species in nature. The objective of this study was to evaluate the allelopathic activity of M. pigra leaf residues on the germination, survival percentage and growth in two weeds, namely popping pod (Ruellia tuberosa L.) and purslane (Portulaca oleracea L.). Experiments were carried out under laboratory (agar medium) and greenhouse (soil medium) conditions with the addition the M. pigra leaf powder at varying concentrations of 1, 2, 3 and 4% (w/w) into the agar and soil medium. Negative and positive effects of M. pigra leaf residues were assessed. The results under two conditions showed the same trend, namely that the M. pigra leaf samples expressed inhibitory effects on the germination, survival percentage and growth of popping pod and exhibited stimulatory effects on purslane for all parameters. The soil experiment showed more prominent effects than the laboratory bioassay, with the dry biomass of popping pod being decreased up to 70.27% whereas the dry biomass of purslane sharply increased up to 1,562.50% and the effects became stronger when the concentration of M. pigra increased. The results indicated that the allelopathic effects of M. pigra were species-specific and concentration-dependent. The M. pigra leaf residues could be considered as a source of biologically active compounds.

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Extract from Mimosa pigra attenuates chronic experimental pulmonary hypertension

Cited by 43 publications

References 32 publications

Ethnomedicinal plants used by traditional healers in the management of HIV/AIDS opportunistic diseases in Rundu, Kavango East Region, Namibia

Ethnomedicinal plants used by traditional healers in the management of HIV/AIDS opportunistic diseases in Rundu, Kavango East Region, Namibia

Structure-Activity Association of Flavonoids in Lung Diseases

Allelopathic Effects of Giant Sensitive Plant (Mimosa pigra) Leaf Powder on Germination and Growth of Popping Pod and Purslane

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