Extract from<i>Acanthopanax senticosus</i>Harms (Siberian Ginseng) Activates NTS and SON/PVN in the Rat Brain

Soya, Hideaki; Deocaris, Custer C.; Yamaguchi, Kaoru; Ohiwa, Nao; Saito, Tsuyoshi; Nishijima, Takeshi; Kato, Morimasa; Tateoka, Masaru; Matsui, Takashi; Okamoto, Masahiro; Fujikawa, Takahiko

doi:10.1271/bbb.80209

Cited by 7 publications

(3 citation statements)

References 20 publications

(27 reference statements)

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“…Therefore, the current results suggest that ASS may be more effective against stress stimuli involving the secretion of CRH rather than AVP. A previous study in which Siberian ginseng ( A. senticosus Harms), which, like A. sieboldianus , is a member of the Araliaceae family, was administered orally found an enhanced anti-stress effect attributed to activation of the noradrenaline system [23]. The A. sieboldianus used in our study may exert a similar anti-stress effect by suppressing the glycolytic mechanism induced by excessive sympathetic nervous system activation in response to physical and psychological stresses and thus inhibiting elevations of the blood lactate concentration.…”

Section: Discussionmentioning

confidence: 99%

The Blood Lactate Increase in High Intensity Exercise Is Depressed by Acanthopanax sieboldianus

et al. 2013

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This study investigates the anti-fatigue effects of Acanthopanax sieboldianus (A. sieboldianus) at various exercise intensities. Two experiments were conducted in 18 Sprague-Dawley rats. In Experiment 1, a three-stage increment test (15 m/min for 5 min, and 20 m/min for 5 min and 25 m/min for 10 min) was performed using a treadmill. In Experiment 2, a 10-min swimming test was conducted. Blood samples were extracted from each rat before, during and after the exercises and the blood concentrations of lactate and glucose measured. In both experiments, water (control) or A. sieboldianus solution (ASS) was administered orally using a zonde 30 min before the exercise. In the swimming test, ASS administration significantly decreased the blood lactate level measured at the end of the exercise and 5 min post-exercise relative to the water group, although the two groups did not differ significantly in the treadmill test. Our study demonstrates that a single oral administration of A. sieboldianus prior to high-intensity exercise significantly decreases the blood lactate concentration suggesting that A. sieboldianus has an intrinsic anti-fatigue effect.

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Section: Discussionmentioning

confidence: 99%

The Blood Lactate Increase in High Intensity Exercise Is Depressed by Acanthopanax sieboldianus

et al. 2013

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“…Accordingly, stress-induced glucocorticoids reduce BDNF expression and impair synaptic plasticity and memory in the hippocampus [38,39,40]. ASH has effects on the CNS, including a protective effect against neurotoxicity, resulting in increased BDNF mRNA levels [41,42,43,44,45]. Thus, anti-depressive effects of ASH may occur through the regulation of BDNF expression.…”

Section: Introductionmentioning

confidence: 99%

Anxiolytic Effects of Acanthopanax senticosus HARMS Occur via Regulation of Autonomic Function and Activate Hippocampal BDNF–TrkB Signaling

Miyazaki

Oikawa

Takekoshi³

et al. 2018

Molecules

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Mental stress, such as anxiety and conflict, causes physiological changes, such as changes in autonomic nervous activity and gastric ulcers. In addition, stress induces glucocorticoids and changes the hippocampal brain-derived neurotrophic factor (BDNF) expression levels. We previously reported that Acanthopanax senticosus HARM (ASH) prevents stress-induced gastric ulcers. Thus, we investigated the potential anxiolytic effect and influence of ASH on the hippocampus BDNF-related protein in male Sprague-Dawley rats fed 1% and 5% ASH extract-containing food for one week using novelty suppressed feeding (NSF) and improved elevated beam walking (IEBW) tests. ASH treatment significantly decreased latency to eat in the NSF test and increased the time spent on the open arm in the IEBW test. ASH5% treatment showed a significant decrease in LFnu, indicative of sympathetic nervous activity, and a significant increase in HFnu, indicative of parasympathetic nervous activity, in the NSF test. In addition, ASH1% and ASH5% treatments significantly decreased LFnu and significantly increased HFnu in the IEBW test. ASH5% treatment significantly increased hippocampal BDNF protein expression in both Western blotting and immunohistochemistry experiments. Our findings suggest that anxiolytic effects of ASH occur via the regulation of autonomic function and increased hippocampal BDNF signaling.

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“…However, when compared with stress management training (SMT), supplementation with Siberian ginseng was found to be non-significant with SMT or their combination (Schaffler et al, 2013), suggesting a physical effect as previously mentioned, rather than mental effect to reduce stress. On the other hand, in the elderly, E. senticosus supplementation has been shown to improve aspects of quality of life (Cicero et al, 2004), which may be related to the release of both NPY and Hsp70 via interaction with human neurons (Asea et al, 2013), and also via c-Fos accumulation in both the supraoptic nuclei (SON) and paraventricular nuclei (PVN) of the rat brain (Soya et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Proliferative and Inhibitory Activity of Siberian ginseng (Eleutherococcus senticosus) Extract on Cancer Cell Lines; A-549, XWLC-05, HCT-116, CNE and Beas-2b

Cichello

Yao²,

Dowell³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Siberian ginseng (Eleutherococcus senticosus) is used primarily as an adaptogen herb and also for its immune stimulant properties in Western herbal medicine. Another closely related species used in East Asian medicine systems i.e. Kampo, TCM (Manchuria, Korea, Japan and Ainu of Hokkaido) and also called Siberian ginseng (Acanthopanax senticosus) also displays immune-stimulant and anti-cancer properties. These may affect tumour growth and also provide an anti-fatigue effect for cancer patients, in particular for those suffering from lung cancer. There is some evidence that a carbohydrate in Siberian ginseng may possess not only immune stimulatory but also anti-tumour effects and also display other various anti-cancer properties. Our study aimed to determine the inhibitory and also proliferative effects of a methanol plant extract of Siberan ginseng (E. senticosus) on various cancer and normal cell lines including: A-549 (small cell lung cancer), XWLC-05 (Yunnan lung cancer cell line), CNE (human nasopharyngeal carcinoma cell line), HCT-116 (human colon cancer) and Beas-2b (human lung epithelial). These cell lines were treated with an extract from E. senticosus that was evaporated and reconstituted in DMSO. Treatment of A-549 (small cell lung cancer) cells with E. senticosus methanolic extract showed a concentration-dependent inhibitory trend from 12.5 -50µg/mL, and then a plateau, whereas at 12.5 and 25 µg/mL, there is a slight growth suppression in QBC-939 cells, but then a steady suppression from 50, 100 and 200µg/mL. Further, in XWLC-05 (Yunnan lung cancer cell line), E. senticosus methanolic extract displayed an inhibitory effect which plateaued with increasing dosage. Next, in CNE (human nasopharyngeal carcinoma cell line) there was a dose dependent proliferative response, whereas in Beas-2 (human lung epithelial cell line), an inhibitory effect. Finally in colon cancer cell line (HCT-116) we observed an initially weak inhibitory effect and then plateau.

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Extract fromAcanthopanax senticosusHarms (Siberian Ginseng) Activates NTS and SON/PVN in the Rat Brain

Cited by 7 publications

References 20 publications

The Blood Lactate Increase in High Intensity Exercise Is Depressed by Acanthopanax sieboldianus

The Blood Lactate Increase in High Intensity Exercise Is Depressed by Acanthopanax sieboldianus

Anxiolytic Effects of Acanthopanax senticosus HARMS Occur via Regulation of Autonomic Function and Activate Hippocampal BDNF–TrkB Signaling

Proliferative and Inhibitory Activity of Siberian ginseng (Eleutherococcus senticosus) Extract on Cancer Cell Lines; A-549, XWLC-05, HCT-116, CNE and Beas-2b

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