Extracranial metastasis of multiforme glioblastoma detected by 11 C-methionine brain PET/CT

García, J.R.; Corbella, Cristina; Baquero, Miguel; Bassa, P.; Solèr, M.

doi:10.1016/j.remnie.2016.10.001

Cited by 1 publication

(1 citation statement)

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“…Pietschmann et al, in their systematic review, assessed articles published from 1928 to 2013 and found 109 eligible studies, with a total of 150 patients diagnosed with GBM systemic metastasis 12 . From the data of the survey carried out for this study, other 14 cases reports were found from 2014 to 2017, totaling 17 patients 8, [13][14][15][16][17][18][19][20][21][22][23][24] . The authors demonstrated that the average time from the initial diagnosis to the metastasis was nine months; the average survival after the metastasis was six months 12 .…”

Section: Introductionmentioning

confidence: 99%

Systemic dissemination of glioblastoma: literature review

Carvalho¹,

Barbosa

Feher

et al. 2019

Rev. Assoc. Med. Bras.

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SUMMARY INTRODUCTION: Glioblastoma (GBM) is the most frequent primary malignant tumor from the central nervous system in adults. However, the presence of systemic metastasis is an extremely rare event. The objective of this study was to review the literature, evaluating the possible biological mechanisms related to the occurrence of systemic metastasis in patients diagnosed with GBM. RESULTS: The mechanisms that may be related to GBM systemic dissemination are the blood-brain barrier breach, often seen in GBM cases, by the tumor itself or by surgical procedures, gaining access to blood and lymphatic vessels, associated with the acquisition of mesenchymal features of invasiveness, resistance to the immune mechanisms of defense and hostile environment through quiescence. CONCLUSIONS: Tumor cells must overcome many obstacles until the development of systemic metastasis. The physiologic mechanisms are not completely clear. Although not fully understood, the pathophysiological understanding of the mechanisms that may be associated with the systemic spread is salutary for a global understanding of the disease. In addition, this knowledge may be used as a basis for a therapy to be performed in patients diagnosed with GBM distant metastasis.

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