Extracranial applications of diffusion-weighted magnetic resonance imaging

Thoeny, Harriet C.; Keyzer, Frederik De

doi:10.1007/s00330-006-0547-0

Cited by 253 publications

(169 citation statements)

References 72 publications

(75 reference statements)

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“…With generation of ADC maps, quantitative analysis can be made with different b values. At least 2 b values are needed for DW imaging analysis, and itis well known that the greater number of b values improves the accuracy of calculated ADC 6,19,[21][22][23][24] . We used 0, 500, and 1000 as the standart b values in our study.…”

Section: Discussionmentioning

confidence: 99%

Abdominopelvic Pain: A Prospective Study of 137 Patients

Özdemir¹,

Metin²,

Metin³

2017

Kafkas J Med Sci

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Aim: This prospective study aims to evaluate the role of diffusionweighted magnetic resonance (DW-MR) imaging in patients presenting with acute abdominopelvic pain, who are decided a follow-up with conservative treatment after admission in the emergency department. Material and Method: A total of 137 consecutive patients with various causes of acute abdominopelvic pain were followed-up with DW-MR imaging to monitor the response to medical treatment after a primary diagnosis made by combination of DW-MR imaging and computed tomography (CT). Results

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Section: Discussionmentioning

confidence: 99%

Abdominopelvic Pain: A Prospective Study of 137 Patients

Özdemir¹,

Metin²,

Metin³

2017

Kafkas J Med Sci

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“…In some scenarios, such indeterminate findings even result in invasive procedures such as biopsies or surgical resections. In light of the superb soft tissue contrast of MRI and its ability to assess cellular density with DWI [7], we anticipated that PET/MRI might reduce indeterminate PET/CT findings by facilitating more conclusive lesion characterization.…”

Section: Discussionmentioning

confidence: 99%

Indeterminate Findings on Oncologic PET/CT: What Difference Does PET/MRI Make?

Fraum

Fowler

McConathy

et al. 2016

Nucl Med Mol Imaging

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Background Positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-[ 18 F]fluoro-D-glucose (FDG) has become the standard of care for the initial staging and subsequent treatment response assessment of many different malignancies. Despite this success, PET/CT is often supplemented by MRI to improve assessment of local tumor invasion and to facilitate detection of lesions in organs with high background FDG uptake. Consequently, PET/MRI has the potential to expand the clinical value of PET examinations by increasing reader certainty and reducing the need for subsequent imaging. This study evaluates the ability of FDG-PET/MRI to clarify findings initially deemed indeterminate on clinical FDG-PET/CT studies. Methods A total of 190 oncology patients underwent whole-body PET/CT, immediately followed by PET/MRI utilizing the same FDG administration. Each PET/CT was interpreted by our institution's nuclear medicine service as a standard-of-care clinical examination. Review of these PET/CT reports identified 31 patients (16 %) with indeterminate findings. Two readers evaluated all 31 PET/CT studies, followed by the corresponding PET/MRI studies. A consensus was reached for each case, and changes in interpretation directly resulting from PET/MRI review were recorded. Interpretations were then correlated with follow-up imaging, pathology results, and other diagnostic studies.Results In 18 of 31 cases with indeterminate findings on PET/CT, PET/MRI resulted in a more definitive interpretation by facilitating the differentiation of infection/inflammation from malignancy (15/18), the accurate localization of FDGavid lesions (2/18), and the characterization of incidental non-FDG-avid solid organ lesions (1/18). Explanations for improved reader certainty with PET/MRI included the superior soft tissue contrast of MRI and the ability to assess cellular density with diffusion-weighted imaging. The majority (12/18) of such cases had an appropriate standard of reference; in all 12 cases, the definitive PET/MRI interpretation proved correct. These 12 patients underwent six additional diagnostic studies to clarify the initial indeterminate PET/ CT findings. In the remaining 13 of 31 cases with indeterminate findings on both PET/CT and PET/MRI, common reasons for uncertainty included the inability to distinguish reactive from malignant lymphadenopathy (4/13) and local recurrence from treatment effect (2/13). Conclusions Indeterminate PET/CT findings can result in equivocal reads and additional diagnostic studies. PET/MRI may reduce the rate of indeterminate findings by facilitating better tumor staging, FDG activity localization, and lesion characterization. In our study, PET/ MRI resulted in more definitive imaging interpretations with high accuracy. PET/MRI also showed potential in reducing the number of additional diagnostic studies prompted by PET/CT findings. Our results suggest that whole-body PET/MRI provides certain diagnostic advantages over PET/CT, promotes more definitive imaging interpretations, and m...

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“…3,4 Bu sayede su moleküllerinin hem hareket kabiliyeti hem de yoğunlukları değerlen-dirilebilir, hücre içi ve dışı kompartmanlar arasın-daki su dengesi ortaya konulabilir.…”

Section: Di̇füzyon Ağirlikli Görüntülemeni̇n Bi̇yoloji̇k Temeli̇ Ve Görüntunclassified

“…1,2 İlk yıl-larda teknik kısıtlılıklardan dolayı yalnızca nöro-radyolojik uygulamalarda kullanılan DAG, son yıllarda manyetik rezonans görüntüleme (MRG) cihazlarında, sekans yazılımlarında ve koil sistemlerindeki teknolojik gelişmeler sayesinde ekstranörolojik birçok alanda kullanım yeri bulmuştur. 1,3,4 Yöntem, günümüzde pediatrik olgularda ekstra-nörolojik organların fonksiyonel durumunu belirlemede, lezyon tespitinde, malign ve benign lezyon ayrımında, lezyonların sınırlarının komşu yapılardan net olarak ayrımında, nekrotik ve solid tümör sahalarının saptanması ile biyopsi kılavuz-luğunda, tedavi yöntemlerinin etkinliğini takip etmede, tedaviye yanıtı tahmin etmede etkin olarak kullanılmaktadır. 1 Bu çalışmada, öncelikle ekstra-nörolojik uygulamalarda DAG'nin doğru uygulanabilmesi ve değerlendirilebilmesi için bilinmesi zorunlu olan temel fizik prensiplerin kısaca gözden geçirilmesi, görüntülemenin yorumlanmasındaki temel faktör-lerin ve nöroradyoloji dışındaki temel kullanım alanlarının sunulması amaçlanmıştır.…”

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