Background and objective: Target-controlled infusions (TCIs) of remifentanil and fentanyl in conscious sedation regimes for extra-corporeal shock-wave lithotripsy have not been reported. We estimated the effect site concentrations of remifentanil and fentanyl needed to obtain adequate analgesia in 50% of patients (EC 50 ) and compared both drugs in terms of intra-and post-procedure complications.Methods: Forty-four adult patients were randomly distributed into two groups: Group R received remifentanil and Group F received fentanyl TCI with initial effect site concentrations of 1.5 and 2 ng mL Ϫ1 , respectively. Pain was assessed using a 10-point verbal analogue scale and Ͻ3 was considered adequate analgesia. Increments or decrements of 0.5 ng mL Ϫ1 were then introduced for subsequent patients according to Dixon's up and down method. During the rest of the procedure, TCI was adjusted to maintain verbal analogue scale Ͻ3.Results: Remifentanil and fentanyl EC 50 were 2.8 ng mL Ϫ1 (95% confidence interval (CI): 1.8-3.7 ng mL Ϫ1 ) and 2.9 ng mL Ϫ1 (95% CI: 1.7-4.1 ng mL Ϫ1 ), respectively (n.s.). At EC 50 , the probability of having a respiratory rate Ͻ10 was 4% (95% CI: 0-57%) for remifentanil and 56% (95% CI: 13-92%) for fentanyl. Hypoxaemia, vomiting and sedation were more frequent in Group F during and after the procedure (P Ͻ 0.05).Conclusions: A similar EC 50 but more respiratory depression, sedation and PONV were found with fentanyl TCI than with remifentanil TCI.The decreased pain associated with newer generation lithotriptors, has allowed the use of conscious sedation techniques instead of general or regional anaesthesia regimes [1]. Reduced recovery times [2] and decreased stone movement by tidal breathing [3] have been described as potential advantages, but these regimes have also been associated with a high incidence of respiratory depression and postoperative nausea and vomiting (PONV) [1,[4][5][6].Target-controlled infusion (TCI) systems use a computer to adjust boluses and infusion rates in order to maintain a desired stable plasma or effect site drug concentration. The use of TCI in conscious sedation may be advantageous because rapid and proportional increments or decrements in drug concentration can be easily obtained, facilitating titration of stable levels of analgesia [7]. Remifentanil and fentanyl have different pharmacokinetic profiles. To our knowledge, comparisons between remifentanil and fentanyl TCIs in conscious sedation regimes for extra-corporeal shock-wave lithotripsy (ESWL) have not been reported.The objectives of our study were to estimate the EC 50 of remifentanil and fentanyl using the highest-intensity stimuli of the lithotriptor, and to