Extracorporeal renal lithotripsy: Evolution of residual lithiasis treated with thiazides

Arrabal‐Martín, Miguel; Fernández-Rodríguez, A.; Arrabal-Polo, Miguel Ángel; García-Ruiz, María Jesús; Zuluaga-Gomez, Armando

doi:10.1016/j.urology.2006.06.007

Cited by 35 publications

(16 citation statements)

References 10 publications

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“…Because of the effects of thiazides to lower urinary calcium excretion, thiazides are also used to prevent recurrence of calcium nephrolithiasis, especially in hypercalciuric subjects [25]. Thiazide treatment is associated with a positive calcium balance with an increase in cortical bone mineral density and therefore has been used to treat osteoporosis and prevent fractures in postmenopausal women [26-28].…”

Section: Clinical Uses Of Thiazidesmentioning

confidence: 99%

Do thiazides worsen metabolic syndrome and renal disease? The pivotal roles for hyperuricemia and hypokalemia

Reungjui

Pratipanawatr²,

Johnson³

et al. 2008

Current Opinion in Nephrology and Hypertension

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Purpose of review-1. To review the current controversies related to the use of thiazide diuretics as first-line treatment of hypertension 2. To discuss the causal roles for hyperuricemia and hypokalemia on the adverse consequences of thiazide usage Recent findings-Thiazides significantly reduce morbidity and mortality in hypertensive subjects. However, there remains debate about thiazide usage as first line treatment of hypertension. This negative impact of thiazides may be partially attributed to the ability of thiazides to exacerbate features of metabolic syndrome and/or increase the risk for developing diabetes. Several clinical trials suggest that thiazide-induced hyperuricemia and hypokalemia may account for some of these negative effects. Thiazide treatment is also associated with a decline of renal function in spite of a lowering blood pressure. In this review, we discuss the clinical and experimental evidence supporting a potential role of hyperuricemia and hypokalemia on the development of renal injury and worsening of the metabolic syndrome..Summary-Hyperuricemia and hypokalemia may have pivotal roles in the exacerbation of the metabolic syndrome in response to thiazides. We propose that controlling serum uric acid and serum potassium could improve thiazide efficacy and also reduce its risk for inducing metabolic syndrome or diabetes.

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Section: Clinical Uses Of Thiazidesmentioning

confidence: 99%

Do thiazides worsen metabolic syndrome and renal disease? The pivotal roles for hyperuricemia and hypokalemia

Reungjui

Pratipanawatr²,

Johnson³

et al. 2008

Current Opinion in Nephrology and Hypertension

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show abstract

“…Thiazides can be effective in both normocalciuric and hypercalciuric patients. The beneficial effects have been confirmed in several studies 6,7 over the last 55 years and are summarized in the recent AUA guideline on medical management of kidney stones 5 . Thiazides directly stimulate calcium resorption in the distal nephron while reducing the 3 extracellular fluid compartment.…”

Section: Thiazidesmentioning

confidence: 73%

Risks associated with drug treatments for kidney stones

York

Borofsky

Lingeman

2015

Expert Opinion on Drug Safety

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“…Genetic studies have revealed this relationship among CLDN14 gen modifications, osteoporosis, and nephrolithiasis [3]. For some years, thiazides have been used for treatment of calcium lithiasis with hypercalciuria, producing excellent results [17,18]; but, it has also been observed that this therapy, although it decreases calciuria and with that the risk of nephrolithiasis formation, does not improve bone mineral density in comparison with usual supplements of calcium and vitamine D. Therefore, it is not indicated for monotherapy in patients with hypercalciuria, calcium lithiasis, and loss of bone mass [19]. The use of alendronate, nonetheless, has proven to decrease calciuria in combination with improvement in bone mineral density.…”

Section: Discussionmentioning

confidence: 99%