Extracorporeal Photopheresis (ECP) Improved Allograft Function and Significantly Reduced Inflammatory Cytokines in Patients (Pts) With Refractory Heart Allograft Dysfunction.

Watanabe, Jun; Shafi, Hedyeh; Patel, JN; Klapper, Ellen; Yang, Zhu; Krivitskiy, Igor; Liou, Frank W.; Kittleson, M.; Jordan, SL; Kobashigawa, J.; Toyoda, Mieko

doi:10.1097/00007890-201407151-00181

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Watanabe et al 40 measured inflammatory cytokines in 13 heart transplant patients with left ventricular dysfunction and/or recurrent AMR treated with ECP. A total of 13 ECP sessions were administered over 6 months.…”

Section: Ecp Treatment For Humoral Immunitymentioning

confidence: 99%

Extracorporeal photopheresis and its role in heart transplant rejection: prophylaxis and treatment

Slomovich

Bell

Clerkin

et al. 2021

Clinical Transplantation

View full text Add to dashboard Cite

Heart transplantation is the gold standard therapeutic option for select patients with end-stage heart failure. Unfortunately, successful long-term outcomes of heart transplantation can be hindered by immune-mediated rejection of the cardiac allograft, specifically acute cellular rejection, antibody-mediated rejection, and cardiac allograft vasculopathy. Extracorporeal photopheresis is a cellular immunotherapy that involves the collection and treatment of white blood cells contained in the buffy coat with a photoactive psoralen compound, 8-methoxy psoralen, and subsequent irradiation with ultraviolet A light. This process is thought to cause DNA and RNA crosslinking, ultimately leading to cell destruction. The true mechanism of therapeutic action remains unknown. In the last three decades, extracorporeal photopheresis has shown promising results and is indicated for a variety of conditions. The American Society for Apheresis currently recommends the use of extracorporeal photopheresis for the treatment of cutaneous T-cell lymphoma, scleroderma, psoriasis, pemphigus vulgaris, atopic dermatitis, graft-versus-host disease, Crohn's disease, nephrogenic systemic fibrosis, and solid organ rejection in heart, lung, and liver transplantation. In this review, we aim to explore the proposed effects of extracorporeal photopheresis and to summarize published data on its use as a prophylactic and therapy in heart transplant rejection.

show abstract

Section: Ecp Treatment For Humoral Immunitymentioning

confidence: 99%