Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models

Millar, Jonathan; Bartnikowski, Nicole; Bahr, Viktor von; Malfertheiner, Maximilian; Obonyo, Nchafatso G.; Belliato, Mirko; Suen, Jacky Y.; McAuley, Daniel F.; Lorusso, Roberto

doi:10.1186/s40635-019-0232-7

Cited by 19 publications

(14 citation statements)

References 46 publications

(75 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, in our case, hypoxemia was resolved after removal of the plastic casts. ECMO aided patient recovery during the critical period of respiratory failure, and therefore, may be a good method of life support before removal of plastic casts in patients with PB and in similar situations [22].…”

Section: Discussionmentioning

confidence: 99%

Plastic bronchitis due to adenoviral infection: a case report

et al. 2020

View full text Add to dashboard Cite

Background: Plastic bronchitis (PB) frequently occurs as a serious postoperative complication of the Fontan procedure. The definitive causes of PB are unknown. Case presentation: Herein, we report a pediatric case of PB secondary to adenoviral infection. A 4-year-old girl was admitted to the general pediatric ward for cough since 2 weeks and fever since 11 days. Consolidated lesions were noted in the right upper and both lower lung lobes. Extracorporeal membrane oxygenation was performed because the patient's respiratory failure remained unalleviated despite the use of a ventilator. Bronchial dendritic casts were extracted using flexible bronchoscopy, and the patient's breathing improved. Pathological examination of the dendritic cast confirmed the diagnosis of type I PB. The exfoliated cells of sputum and cells from bronchoalveolar lavage fluid were positive for adenoviral antigen. Human adenovirus 7 was detected by nextgeneration sequencing of the bronchoalveolar lavage fluid. The patient recovered and was discharged 39 days after admission without recurrence of cough or wheezing. Conclusions: PB due to human adenovirus 7 infection should be considered in children with persistent respiratory failure. Flexible bronchoscopy should be performed early to confirm diagnosis and to remove any airway obstruction.

show abstract

Section: Discussionmentioning

confidence: 99%

Plastic bronchitis due to adenoviral infection: a case report

et al. 2020

View full text Add to dashboard Cite

show abstract

“…To better study the effects of VV-ECMO, reliable animal models are needed [12]. Rats have multiple advantages as animal models of human conditions, including anatomical structures that are almost identical to human ones, small volume, low cost, and easy handling relative to large animal models [13].…”

Section: Discussionmentioning

confidence: 99%

Establishment of a venovenous extracorporeal membrane oxygenation in a rat model of acute respiratory distress syndrome

Huang

Zhang

et al. 2021

Perfusion

View full text Add to dashboard Cite

Introduction: Venovenous extracorporeal membrane oxygenation (VV ECMO) is now considered a reasonable option to salvage acute respiratory distress syndrome (ARDS). However, we lack a rodent model for experimental studies. This study was undertaken to establish an animal model of VV ECMO in ARDS rats. Methods: A total of 18 Sprague-Dawley (SD) rats (350 ± 50 g) were used in this study. Using a rat model of oleic acid (OA)-induced ARDS, VV ECMO was established through cavoatrial cannulation of the right jugular vein for venous drainage and venous reinfusion with a specially designed three-cavity catheter. Continuous arterial pressure monitoring was implemented by using a catheter through cannulation of the right femoral artery. The central temperature was monitored with a rectal probe. Arterial blood gas monitoring was implemented by a blood gas analyzer at three-time points: at baseline, 1-hour (after OA modeling), and 3.5-hour (after VV ECMO support). Lung tissue and bronchoalveolar lavage fluid were harvested respectively for protein concentration and pulmonary histologic evaluation to confirm the alleviation of lung injury during VV ECMO. Results: Following ARDS induced by OA, ten rats were successfully established on VV ECMO without failure and survived the ECMO procedure. VV ECMO alleviated lung injury and restored adequate circulation for the return of lung function and oxygenation. VV ECMO was associated with decreased lung injury score, wet/dry weight ratio, and ﬂuid leakage into airspaces. Conclusion: We have established a reliable, economical, and functioning ARDS rat model of VV ECMO.

show abstract

“…Besides, when used independently without alternating-current supply, the pump drive can support for at least 180 min. The scheduled ECMO duration of previous preclinical evaluations ranged from several hours to at most 4 weeks (10,(12)(13)(14). Taken the previous samples and the durability of the PMP oxygenator together, we tested the single-use pump and ECMO device for 7 days in the ovine model.…”

Section: The Oassist Ecmo System Can Provide Durable Heart-lung Supportmentioning

confidence: 99%

Safety and Efficacy of a Novel Centrifugal Pump and Driving Devices of the OASSIST ECMO System: A Preclinical Evaluation in the Ovine Model

Gao

et al. 2021

Front. Med.

View full text Add to dashboard Cite

Background: Extracorporeal membrane oxygenation (ECMO) provides cardiopulmonary support for critically ill patients. Portable ECMO devices can be applied in both in-hospital and out-of-hospital emergency conditions. We evaluated the safety and biocompatibility of a novel centrifugal pump and ECMO device of the OASSIST ECMO System (Jiangsu STMed Technologies Co., Suzhou, China) in a 168-h ovine ECMO model.Methods: The portable OASSIST ECMO system consists of the control console, the pump drive, and the disposable centrifugal pump. Ten healthy sheep were used to evaluate the OASSIST ECMO system. Five were supported on veno-venous ECMO and five on veno-arterial ECMO, each for 168 h. The systemic anticoagulation was achieved by continuous heparin infusion to maintain the activated clotting time (ACT) between 220 and 250 s. The rotary speed was set at 3,200–3,500 rpm. The ECMO configurations and ACT were recorded every 6 hours (h). The free hemoglobin (fHb), complete blood count, and coagulation action test were monitored, at the 6th h and every 24 h after the initiation of the ECMO. The dissection of the pump head and oxygenator were conducted to explore thrombosis.Results: Ten sheep successfully completed the study duration without device-related accidents. The pumps ran stably, and the ECMO flow ranged from 1.6 ± 0.1 to 2.0 ± 0.11 L/min in the V-V group, and from 1.8 ± 0.1 to 2.4 ± 0.14 L/min in the V-A group. The anticoagulation was well-performed. The ACT was maintained at 239.78 ± 36.31 s, no major bleeding or thrombosis was observed during the ECMO run or in the autopsy. 3/5 in the V-A group and 4/5 in the V-V group developed small thrombus in the bearing pedestal. No obvious thrombus formed in the oxygenator was observed. The hemolytic blood damage was not significant. The average fHb was 0.17 ± 0.12 g/L. Considering hemodilution, the hemoglobin, white blood cell, and platelets didn't reduce during the ECMO runs.Conclusions: The OASSIST ECMO system shows satisfactory safety and biocompatibility for the 168-h preclinical evaluation in the ovine model. The OASSIST ECMO system is promising to be applied in clinical conditions in the future.

show abstract

Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models

Cited by 19 publications

References 46 publications

Plastic bronchitis due to adenoviral infection: a case report

Plastic bronchitis due to adenoviral infection: a case report

Establishment of a venovenous extracorporeal membrane oxygenation in a rat model of acute respiratory distress syndrome

Safety and Efficacy of a Novel Centrifugal Pump and Driving Devices of the OASSIST ECMO System: A Preclinical Evaluation in the Ovine Model

Contact Info

Product

Resources

About