Extracorporeal Membrane Oxygenation as Rescue Therapy for Covid-19 Induced Hypoxia: Single-Center Study

Abstract

To examine COVID-19 patients requiring invasive mechanical ventilation (MV) and/or Extracorporeal Membrane Oxygenation (ECMO) to better understand patient selection for ECMO, clinical management, and short-term outcomes. METHODS: Retrospective study of patients >18-years-old admitted to the hospital with COVID-19 requiring MV. Lungprotective ventilation was used in all patients with initial set PEEP of 8-10 cm H20 for plateau pressure <30 cm H20. ECMO was considered per pre-specified institutional criteria for refractory hypoxemia despite maximum-medical therapy, in qualifying patients. Exclusion criteria for ECMO included age >65 years, multi-system organ failure, and MV >10 d. Data captured included baseline patient characteristics, co-morbidities, pre-ECMO respiratory support, ECMO settings, laboratory results, and COVID-19 therapeutic interventions.

COVID-19: a historicidade das terapêuticas no primeiro ano da Pandemia

“…Quase metade dos pacientes com COVID-19 recebendo Ventilação Mecânica Invasiva (VMI) morreram com base na taxa de letalidade relatado pelo estudo, maior em pacientes mais velhos e nos primeiros epicentros da pandemia, o que pode ser influenciado pelos recursos limitados da UTI (Lim et al, 2021). Os desfechos dos grupos de pacientes com a COVID-19 submetidos a VMI que preencheram os critérios dos procedimentos de oxigenioterapia por membrana extracorpórea não foram satisfatórios quando comparados entre os grupos, pois associou aumento do tempo de internamento na UTI, nos marcadores de coagulação, na inflamação e lesão cardíaca, além de morte (Alnababteh et al, 2020).…”