Extracorporeal Membrane Oxygenation as “Bridge” to Lung Transplantation: What Remains in Order to Make It Standard of Care?

Sorbo, Lorenzo Del; Ranieri, V. Marco; Keshavjee, Shaf

doi:10.1164/rccm.201202-0193ed

Cited by 28 publications

(25 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Posttransplant lymphoproliferative disease (PTLD) is mainly derived from B cells in transplant patients [26, 27]. It is often associated with EBV infection in the context of an impaired immune surveillance system.…”

Section: 2 Ebv-associated B-cell Lymphomasmentioning

confidence: 99%

Current Progress in EBV-Associated B-Cell Lymphomas

Pei

Lewis

2017

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Epstein-Barr virus (EBV) was the first human tumor virus discovered more than 50 years ago. EBV-associated lymphomagenesis is still a significant viral-associated disease as it involves a diverse range of pathologies, especially B-cell lymphomas. Recent development of high-throughput next-generation sequencing technologies and in vivo mouse models have significantly promoted our understanding of the fundamental molecular mechanisms which drive these cancers and allowed for the development of therapeutic intervention strategies. This review will highlight the current advances in EBV-associated B-cell lymphomas, focusing on transcriptional regulation, chromosome aberrations, in vivo studies of EBV-mediated lymphomagenesis, as well as the treatment strategies to target viral-associated lymphomas.

show abstract

Section: 2 Ebv-associated B-cell Lymphomasmentioning

confidence: 99%

Current Progress in EBV-Associated B-Cell Lymphomas

Pei

Lewis

2017

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

show abstract

“…In the case of patients with hypercapnic respiratory failure due to chronic obstructive pulmonary disease, or chronic end-stage respiratory failure treated with VV-ECMO or ECCO 2 R, the findings of recent pilot studies have suggested that the optimal management is to wean from MV as soon as possible once ECMO has been established [9,11,77]. In this case, ECMO without invasive MV, named awake ECMO, seems feasible, is relevant and has been associated with good results [9,11,77].…”

Section: Evidence and Current Recommendationsmentioning

confidence: 99%

“…In this case, ECMO without invasive MV, named awake ECMO, seems feasible, is relevant and has been associated with good results [9,11,77]. …”

Section: Evidence and Current Recommendationsmentioning

confidence: 99%

Mechanical ventilation during extracorporeal membrane oxygenation

et al. 2014

View full text Add to dashboard Cite

The timing of extracorporeal membrane oxygenation (ECMO) initiation and its outcome in the management of respiratory and cardiac failure have received considerable attention, but very little attention has been given to mechanical ventilation during ECMO. Mechanical ventilation settings in non-ECMO studies have been shown to have an effect on survival and may also have contributed to a treatment effect in ECMO trials. Protective lung ventilation strategies established for non-ECMO-supported respiratory failure patients may not be optimal for more severe forms of respiratory failure requiring ECMO support. The influence of positive end-expiratory pressure on the reduction of the left ventricular compliance may be a matter of concern for patients receiving ECMO support for cardiac failure. The objectives of this review were to describe potential mechanisms for lung injury during ECMO for respiratory or cardiac failure, to assess the possible benefits from the use of ultra-protective lung ventilation strategies and to review published guidelines and expert opinions available on mechanical ventilation-specific management of patients requiring ECMO, including mode and ventilator settings. Articles were identified through a detailed search of PubMed, Ovid, Cochrane databases and Google Scholar. Additional references were retrieved from the selected studies. Growing evidence suggests that mechanical ventilation settings are important in ECMO patients to minimize further lung damage and improve outcomes. An ultra-protective ventilation strategy may be optimal for mechanical ventilation during ECMO for respiratory failure. The effects of airway pressure on right and left ventricular afterload should be considered during venoarterial ECMO support of cardiac failure. Future studies are needed to better understand the potential impact of invasive mechanical ventilation modes and settings on outcomes.

show abstract

“…[3][4][5][6][7][8][9][10][11][12][13] With the majority of studies being single-center experiences, ECMO before LTx remains controversial. 14 ECMO before LTx in children is even less established, [15][16][17][18] but a recent study 19 reported that ECMO before LTx in pediatric patients did not negatively impact survival. With no current medical literature in adult patients regarding the influence of age on survival, we developed this study to determine whether age would impact risk of death in patients Z18 years of age who were on ECMO at the time of LTx.…”

mentioning

confidence: 99%