Extracorporeal Membrane-Gas Exchange

Lewandowski, K.; Lewandowski, Monika

doi:10.1016/b0-12-370879-6/00152-6

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…20 The theory behind this technique is that the combination of peri-portal inflammation in the emoblized liver and the diversion of portal venous blood to the FLR stimulate regeneration. 20,21,22 Some authors have reported administering Yttrium-90 labelled microspeheres to the hemi-liver intended for resection resulting in ionizing radiation injury to the diseased hemi-liver 23,24 . This Yttrium-90 radioembolization maintains flow to the FLR, induces injury and inflammation at the diseased hemi-liver, and has the theoretic advantage to simultaneously induce FLR growth and control tumour on the contralateral side, 20,24 Surgical options also exist when there is metastatic disease on both sides of the liver.…”

Section: Discussionmentioning

confidence: 99%

“…20,21,22 Some authors have reported administering Yttrium-90 labelled microspeheres to the hemi-liver intended for resection resulting in ionizing radiation injury to the diseased hemi-liver 23,24 . This Yttrium-90 radioembolization maintains flow to the FLR, induces injury and inflammation at the diseased hemi-liver, and has the theoretic advantage to simultaneously induce FLR growth and control tumour on the contralateral side, 20,24 Surgical options also exist when there is metastatic disease on both sides of the liver. The first option is a two-stage hepatectomy with vein ligation, where the wedge resections performed to remove metastases from the FLR along with surgical ligation of the contralateral vein.…”

Section: Discussionmentioning

confidence: 99%

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Future Liver Remnant Regeneration Post Hepatectomy: Histologic Changes in an Animal Model

Kedambady,

Gardner,

Louboutin

et al. 2024

MRAJ

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Background: The liver possesses remarkable regenerative abilities following parenchymal injury. This study aimed to assess and document the microscopic regenerative changes in the rat liver using a partial hepatectomy model. Methodology: Adult male Sprague Dawley rats weighing approximately 200-300 grams were subjected to partial hepatectomy, leaving approximately 70% future liver remnant. The rats were euthanized at designated time intervals (1/2 hour, 48 hours, 72 hours, 7 days, 11 days, and 14 days) for histological analysis of the liver. Results: Liver regeneration was observed within 1 week of partial hepatectomy. Cytoplasmic vacuolization increased until day 7, but decreased significantly during the regenerative process. Disruption of cytoplasmic membranes and blurring of cell-to-cell and cell-to-sinusoidal space boundaries decreased notably from day 11. Necrosis involving central veins and portal tracts was observed on the first day after hepatectomy. By day 7, the portal tract exhibited granulomatous inflammation with conglomerates of epithelioid macrophages forming giant cells. The sinusoidal spaces displayed increased lymphocyte volume on day 7. Patchy portal inflammation consisting of lymphocytes, plasma cells, occasional eosinophils, and monocytes was observed from day 7 post-hepatectomy. Conclusion: In this partial hepatectomy animal model, the inflammatory cascade was evident through confluent necrosis affecting approximately 10% of the hepatic parenchyma, along with subcapsular infarction. Cytoplasmic vacuolization affected approximately 50% of the cells. The study documented various histological changes during the post-hepatectomy period, demonstrating the initiation of hepatocyte regeneration within one week.

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