Extracorporeal focused ultrasound surgery for treatment of human solid carcinomas: early Chinese clinical experience

Wu, Feng; Wang, Zhibiao; Chen, Wenzhi; Zhang, Jianzhong; Bai, Jing; Zhu, Hui; Li, Kequan; Xie, Fang-Lin; Chen, Jin; Su, Hai-Bing; Gao, Gen-Wu

doi:10.1016/j.ultrasmedbio.2003.10.010

Cited by 243 publications

(157 citation statements)

References 43 publications

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“…Today, US ablative therapy is being investigated or clinically used in numerous applications in the prostate (16)(17)(18)(19), uterine fibroids (20,21), liver (22,23), kidney (24,25), breast (26), or brain (27). Depending on the anatomic location, optimal transmission of the US energy is achieved either by extracorporeal access (abdomen, uterus, brain, bone, kidney, or breast), transrectal/transurethral access (prostate), or endoluminal access (biliary duct, esophagus, rectum).…”

mentioning

confidence: 99%

Automatic temperature control for MR-guided interstitial ultrasound ablation in liver using a percutaneous applicator: Ex vivo and in vivo initial studies

Delabrousse¹,

Salomir²,

Birer³

et al. 2010

Magn. Reson. Med.

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Image-guided thermal ablation offers minimally invasive options for treating hepatocellular carcinoma and colorectal metastases in liver. Here, the feasibility and the potential benefit of active temperature control for MR-guided percutaneous ultrasound ablation was investigated in pig liver. An MR-compatible interstitial ultrasound applicator (flat transducer), a positioning system with rotation-translation guiding frame, and an orbital ring holder were developed.Step-by-step rotated elementary lesions were produced, each being formed by directive heating of a flame-shaped volume of tissue. In vivo feasibility of automatic temperature control was investigated on two pigs. Proton Resonance Frequency Shift (PRFS)-based MR thermometry was performed on a 1.5-T clinical scanner, using SENSE acceleration and respiratory gating. MR follow-up of animals and macroscopic analysis were performed at 3 and, respectively, 4 days postprocedure. No sonication-related radiofrequency artifacts were detected on MR images. The temperature controller converged to the target elevation within 62°C unless the requested power level exceeded the authorized limit. Large variability of the controller's applied powers from one sonication to another was found both ex vivo and in vivo, indicating highly anisotropic acoustic coupling and/or tissue response to identical beam pattern along different radial directions. The automatic control of the temperature enabled reproducible shape of lesions (15 6 2 mm radial depth). Magn Reson Med 63:667-679, 2010.V C 2010 Wiley-Liss, Inc.

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mentioning

confidence: 99%

Automatic temperature control for MR-guided interstitial ultrasound ablation in liver using a percutaneous applicator: Ex vivo and in vivo initial studies

Delabrousse¹,

Salomir²,

Birer³

et al. 2010

Magn. Reson. Med.

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“…It allowed minimal thermal damage to tissue located between the transducer and the focal point (110). Clinical results for HIFU ablation of the tumor from China produced some encouraging findings in terms of significant tumor shrinkage and prolonged survival of patients (111)(112)(113)(114).…”

Section: High Intensity Focused Ultrasound (Hifu)mentioning

confidence: 99%

Bridging and downstaging therapy in patients suffering from hepatocellular carcinoma waiting on the list of liver transplantation

She¹,

Cheung²

2016

Transl. Gastroenterol. Hepatol.

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Hepatocellular carcinoma (HCC) is a common primary malignancy worldwide especially in the patients with the background of chronic liver disease. Liver transplantation (LT) is the only curative treatment effective for both malignancy as well as the cirrhosis and portal hypertension. Unfortunately, living donor is not always possible and the deceased graft is scarce. Neoadjuvant therapies, therefore, have been developed as a downstaging treatment to try to downstage the tumor within the transplant criteria, or as a bridging therapy to control the tumor growth in patients while waiting in the transplant list. This paper reviewed the common modalities used as bridging and downstaging therapies for patients suffering from HCC before undergoing LT.

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“…HIFU is a clinical reality. In China more than 10,000 people have been treated for bone tumors, liver cancers, and soft tissue sarcoma [13,20], in Europe and Japan HIFU is a robust alternative to conventional surgery for prostate cancer [21,22], and in the United States clinical trials are underway for prostate cancer and catheter wound sealing.…”

Section: High Intensity Focused Ultrasoundmentioning

confidence: 99%

“…However, to maintain a controlled treatment and avoid lesion distortion, extended cooling times (minutes) were needed between adjacent lesions and for large tumors this approach resulted prohibitively long [26,27]. More recently, the HIFU transducer is moved continuously, tissue is ablated in stripes, and real-time imaging is used to guide HIFU and assess the damage [13,20]. The imaging feedback allows the treatment protocol to be changed in real time and to be adapted on the new requirements.…”

Section: High Intensity Focused Ultrasoundmentioning

confidence: 99%

Therapeutic ultrasound: Surgery and drug delivery

Curra

Crum

2003

Acoust. Sci. & Tech.

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The field of therapeutic ultrasound is emerging with strong potential and broad medical applications. Characterized by its ability to penetrate at depth inside the body without harming intervening tissue, ultrasound has posed the basis for a new array of noninvasive therapies. Al low intensities, important interactions occur in the tissue; wound healing is accelerated, functional recovery is enhanced, and bone growth is more rapid. At moderate intensities, cellular membranes show transient permeability, blood clots dissolution is increased, and gene-transfection is accomplished. At higher intensities, ultrasound produces lesions and stops bleeding by heating the tissue beyond its protein denaturalization threshold and thus provides a noninvasive, bloodless alternative to conventional surgery. This article presents a review of moderate and high intensity applications, including their mechanisms of action and the imaging modalities used for guidance and monitoring.

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Extracorporeal focused ultrasound surgery for treatment of human solid carcinomas: early Chinese clinical experience

Cited by 243 publications

References 43 publications

Automatic temperature control for MR-guided interstitial ultrasound ablation in liver using a percutaneous applicator: Ex vivo and in vivo initial studies

Automatic temperature control for MR-guided interstitial ultrasound ablation in liver using a percutaneous applicator: Ex vivo and in vivo initial studies

Bridging and downstaging therapy in patients suffering from hepatocellular carcinoma waiting on the list of liver transplantation

Therapeutic ultrasound: Surgery and drug delivery

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