Extracorporeal Cardiac Shock Wave Therapy Markedly Ameliorates Ischemia-Induced Myocardial Dysfunction in Pigs in Vivo

Nishida, Takahiro; Shimokawa, Hiroaki; Oi, Keiji; Tatewaki, Hideki; Uwatoku, Toyokazu; Abe, Kohtaro; Matsumoto, Yasuharu; Kajihara, Noriyoshi; Eto, Masataka; Matsuda, Takehisa; Yasui, Hirofumi; Takeshita, Akira; Sunagawa, Kenji

doi:10.1161/01.cir.0000148849.51177.97

Cited by 339 publications

(387 citation statements)

References 20 publications

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“…In view of this theory, the therapeutic results of ESWT in diVerent heterogeneous indications such as pain diseases, non-unions, induratio penis plastica [27], and ESWT treatment of muscular malfunctions [6] may be considered as reorganization of pathologic reXex patterns. Muscle and/or vessel tone are considered to be aVected by intense stimulation of ESWT.…”

Section: Discussionmentioning

confidence: 99%

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A neural model for chronic pain and pain relief by extracorporeal shock wave treatment

Wess

2008

Urol Res

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The paper develops a new theory of chronic pain and pain relief by extracorporeal shock wave treatment. Chronic pain without underlying anatomical disorder is looked at as a pathological control function of memory. Conditioned reXexes are considered to be engraved memory traces linking sensory input of aVerent signals with motor response of eVerent signals. This feature can be described by associative memory functions of the nervous system. Some conditioned reXexes may cause inappropriate or pathological reactions. Consequently, a circulus vitiosus of pain sensation and muscle and/or vessel contraction is generated when pain becomes chronic (pain spiral). The key feature is a dedicated engram responsible for a pathological (painful) reaction. The pain memory may be explained by the concept of a holographic memory model published by several authors. According to this model it is shown how nervous systems may generate and recall memory contents. The paper shows how extracorporeal shock wave treatment may reorganize pathologic memory traces, thus giving cause to real and permanent pain relief. In a generalized manner, the idea of associative memory functions may help in the understanding of conditioning as a learning process and explain extracorporeal shock wave application as an eYcient treatment concept for chronic pain. This concept may open the door for new treatment approaches to chronic pain and several other disorders of the nervous system.

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Section: Discussionmentioning

confidence: 99%

“…Recent publications [5,6] claim revascularization stimulated by shock waves to be the basic mechanism of pain relief and tissue healing. Pain relief is not the only eVect associated with ESWT.…”

Section: Introductionmentioning

confidence: 99%

A neural model for chronic pain and pain relief by extracorporeal shock wave treatment

Wess

2008

Urol Res

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“…No rise in CK, CkmB or Troponin was observed in that study. Vascular density increased in the shock wave 4 treated area and VEGF production was enhanced in the ischemic myocardium in vivo [14].…”

Section: Introductionmentioning

confidence: 90%

“…Recently Nishida et al performed extracorporeal shock wave application on the ischemic myocardial region (200 shots/spot for 9 spots at 0,09 mJ/mm 2 ) in a porcine model of chronic myocardial ischemia [14]. The cardiac shock wave therapy intervention improved global and regional myocardial functions in the treated animals as well as regional perfusion measured as myocardial blood flow of the chronic ischemic region without any adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Effects of shock wave therapy in the skin of patients with progressive systemic sclerosis: a pilot study

et al. 2010

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Results: After ESWT we observed a rapid and persistent reduction of RSS and decrease of VAS. There was no difference in skin thickness before and after ESWT; however we observed a more regular skin structure and an improvement in skin vascularization 90 days after treatment. EPCs and CECs increased 60 and 90 days after treatment, while serological biomarkers showed no variation before and after therapy. Conclusions: ESWT resulted in an improvement of VAS, RSS and of skin vascularscore. An increase of CECs and EPCs was also observed after therapy.

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“…Some studies have demonstrated that lowenergy extracorporeal shock wave therapy could upregulate angiogenic factors in cultured endothelial cells in vitro 19 and enhances angiogenesis in the ischaemic myocardium and normalises myocardial function in a porcine model of chronic myocardial ischaemia. 20 It has also shown to improve left ventricle remodelling after acute myocardial infarction in pigs when therapy is started in an early phase. 21 In nine patients with endstage coronary artery disease ECST improved symptoms of myocardial ischaemia and also improved myocardial perfusion as evaluated by dipyridamole stress thallium scintigraphy without any major adverse effects.…”

Section: Enhanced External Counterpulsationmentioning

confidence: 99%

A historical perspective towards a non-invasive treatment for patients with atherosclerosis

Slijkhuis¹,

Mali²,

Appelman³

2009

NHJL

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The history of atherosclerosis and cardiovascular disease dates back to ancient times. From the teachings of Galen to the response-to-injury hypothesis of Russel Ross, we have now arrived at the concept of the vulnerable plaque. Next to the development of new treatment options for patients with atherosclerosis, also novel diagnostic imaging techniques have been developed to visualise the arterial wall and to characterise plaque composition. In this article the historical context of atherosclerosis and the attempts towards a noninvasive therapy for patients with atherosclerotic diseases are described. (Neth Heart J 2009;17: 140-5.)

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Extracorporeal Cardiac Shock Wave Therapy Markedly Ameliorates Ischemia-Induced Myocardial Dysfunction in Pigs in Vivo

Abstract: These results suggest that extracorporeal cardiac SW therapy is an effective and noninvasive therapeutic strategy for ischemic heart disease.

Cited by 339 publications

References 20 publications

A neural model for chronic pain and pain relief by extracorporeal shock wave treatment

A neural model for chronic pain and pain relief by extracorporeal shock wave treatment

Effects of shock wave therapy in the skin of patients with progressive systemic sclerosis: a pilot study

A historical perspective towards a non-invasive treatment for patients with atherosclerosis

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