Extracorporeal apheresis therapy for Alzheimer disease—targeting lipids, stress, and inflammation

Bornstein, Stefan R.; Voit-Bak, Karin; Rosenthal, Peter; Tselmin, Sergey; Julius, Ulrich; Schatz, Ulrike; Boehm, Bernhard O.; Thuret, Sandrine; Kempermann, Gerd; Reichmann, Heinz; Chrousos, George P.; Licinio, Júlio; Wong, Ma Li; Straube, Richard

doi:10.1038/s41380-019-0542-x

Cited by 18 publications

(12 citation statements)

References 69 publications

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“…Since this beneficial effect occurred only several months after initiation of treatment with rituximab, it may be attributed to the wash-out of the autoantibodies due to the elimination of the short-lived antibody producing plasma cells related to the CD20+ memory B cells. A more immediate therapeutic strategy with less side effects may involve immune apheresis or other forms of extracorporeal apheresis such a neuro- or cerebropheresis [ 10 ].…”

Section: Targeting Neurotransmitters Ab In Me/cfsmentioning

confidence: 99%

Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis?

Bornstein

Voit-Bak²,

Donate³

et al. 2021

Mol Psychiatry

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As millions of patients have been infected by SARS-CoV-2 virus a vast number of individuals complain about continuing breathlessness and fatigue even months after the onset of the disease. This overwhelming phenomenon has not been well defined and has been called “post-COVID syndrome” or “long-COVID” [1]. There are striking similarities to myalgic encephalomyelitis also called chronic fatigue syndrome linked to a viral and autoimmune pathogenesis. In both disorders neurotransmitter receptor antibodies against ß-adrenergic and muscarinic receptors may play a key role. We found similar elevation of these autoantibodies in both patient groups. Extracorporeal apheresis using a special filter seems to be effective in reducing these antibodies in a significant way clearly improving the debilitating symptoms of patients with chronic fatigue syndrome. Therefore, such a form of neuropheresis may provide a promising therapeutic option for patients with post-COVID-19 syndrome. This method will also be effective when other hitherto unknown antibodies and inflammatory mediators are involved.

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Section: Targeting Neurotransmitters Ab In Me/cfsmentioning

confidence: 99%

Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis?

Bornstein

Voit-Bak²,

Donate³

et al. 2021

Mol Psychiatry

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“…Compelling evidence supports that lipid metabolism and the pathogenesis of cognitive disorder are closely linked. In observational studies, high levels of serum cholesterol have been associated with an increased risk of Alzheimer’s disease ( 32 ). Lipids are essential in maintaining brain function.…”

Section: Introductionmentioning

confidence: 99%

Danggui-Shaoyao-San Attenuates Cognitive Impairment via the Microbiota–Gut–Brain Axis With Regulation of Lipid Metabolism in Scopolamine-Induced Amnesia

et al. 2022

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Danggui-Shaoyao-San (DSS) has a long history of being used as a traditional medicine (TCM) and has been reported to show therapeutic effects in alleviating the symptoms of cognitive impairment. The purpose of this study was to investigate whether DSS treatment attenuates cognitive impairment via the microbiota–gut–brain axis in scopolamine-induced amnesia. In this work, we first performed the Morris water maze (MWM) test and novel object recognition (NOR) test to evaluate the memory function of treated C57BL/6N mice. Then we evaluated 16S rRNA for gut microbiota analysis, as well as assessment of blood–brain barrier function and intestinal barrier function and lipid metabolism analysis on tissues from different groups. We hypothesised that DSS may affect brain function and behavior through the gut–brain axis in a bidirectional interplay with both top-down and bottom-up regulation. Furthermore, in order to confirm whether intestinal flora plays a crucial role in scopolamine-induced amnesia, C57BL/6N mice were treated with fecal microbial transplantation (FMT), and then behavioral tests were performed. The mice’s feces were simultaneously evaluated by 16S rRNA analysis. The result supported that the FMT-induced improvement in cognitive function highlights the role of the gut microbiota–brain axis to mediate cognitive function and behavior. Besides theses works, more findings indicated that DSS altered lipid metabolism by activating LXR-PPAR-γ and repaired mucosal barrier dysfunction assessed with a broad range of techniques, which attenuated cognitive impairment via the microbiota–gut–brain axis.

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“…Lipoprotein apheresis could be an attractive alternative therapeutic approach to treat critically ill patients. Apheresis has been shown to mediate lipid-lowering and anti-inflammatory effects [73]. This might mediate beneficial effects in COVID-19 patients with elevated CRP levels and inflammation.…”

Section: Role Of Lipids Environmental Pollutants and Therapeutic Apmentioning

confidence: 99%

“…Environmental apheresis ® is therefore useful to improve parameters of metabolic inflammation and hyperlipidemia, which have been shown to be major risk factors for the development of severe Coronavirus disease 2019. Furthermore, it has been shown to improve neuroinflammation and polyneuropathy [73,77]. Thus, the removal and reduction of environmental pollutants together with the reduction of lipids and inflammatory factors may provide a protective mechanism for prevention and mitigation of severe corona virus infections.…”

Section: Role Of Lipids Environmental Pollutants and Therapeutic Apmentioning

confidence: 99%

Is There a Role for Environmental and Metabolic Factors Predisposing to Severe COVID-19?

Bornstein

Voit-Bak²,

Schmidt³

et al. 2020

Horm Metab Res

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The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic affects people around the world. However, there have been striking differences in the number of infected individuals and deaths in different countries. Particularly, within Central Europe in countries that are similar in ethnicity, age, and medical standards and have performed similar steps of containment, such differences in mortality rates remain inexplicable. We suggest to consider and explore environmental factors to explain these intriguing variations. Countries like Northern Italy, France, Spain, and UK have suffered from 5 times more deaths from the corona virus infection than neighboring countries like Germany, Switzerland, Austria, and Denmark related to the size of their respective populations. There is a striking correlation between the level of environmental pollutants including pesticides, dioxins, and air pollution such as NO2 known to affect immune function and healthy metabolism with the rate of mortality in COVID-19 pandemic in these European countries. There is also a correlation with the use of chlorination of drinking water in these regions. In addition to the improvement of environmental protective programs, there are possibilities to lower the blood levels of these pollutants by therapeutic apheresis. Furthermore, therapeutic apheresis might be an effective method to improve metabolic inflammation, altered vascular perfusion, and neurodegeneration observed as long-term complications of COVID-19 disease.

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Extracorporeal apheresis therapy for Alzheimer disease—targeting lipids, stress, and inflammation

Cited by 18 publications

References 69 publications

Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis?

Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis?

Danggui-Shaoyao-San Attenuates Cognitive Impairment via the Microbiota–Gut–Brain Axis With Regulation of Lipid Metabolism in Scopolamine-Induced Amnesia

Is There a Role for Environmental and Metabolic Factors Predisposing to Severe COVID-19?

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