2012
DOI: 10.1016/j.annemergmed.2011.07.029
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Extracorporeal Albumin Dialysis in Three Cases of Acute Calcium Channel Blocker Poisoning With Life-Threatening Refractory Cardiogenic Shock

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Cited by 35 publications
(25 citation statements)
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“… 124 , 125 One human case series 126 and two case reports 127 , 128 suggested use of plasma exchange to decrease verapamil concentrations and improve hemodynamics. One human case series of three patients 129 and one case report 130 suggested the use of extracorporeal albumin dialysis to improve hemodynamics without a clear impact on the serum CCB concentrations. Only human case reports were found for charcoal hemoperfusion; 131 continuous venovenous hemodiafiltration; 132–135 insertion of an intra-aortic balloon pump, 136 Impella device, 137 and methylene blue.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“… 124 , 125 One human case series 126 and two case reports 127 , 128 suggested use of plasma exchange to decrease verapamil concentrations and improve hemodynamics. One human case series of three patients 129 and one case report 130 suggested the use of extracorporeal albumin dialysis to improve hemodynamics without a clear impact on the serum CCB concentrations. Only human case reports were found for charcoal hemoperfusion; 131 continuous venovenous hemodiafiltration; 132–135 insertion of an intra-aortic balloon pump, 136 Impella device, 137 and methylene blue.…”
Section: Resultsmentioning
confidence: 99%
“…93–94 Extracorporeal life support 22 for patients with cardiac arrest or severe shock refractory to conventional therapy reported a benefit in survival. Two patients survived with albumin dialysis, 129 , 130 and only animal studies supported the use of Bay K8644. 100 , 101 , 103…”
Section: Resultsmentioning
confidence: 99%
“…There are also more specific treatment modalities for poisonings with cardiovascular agents (e.g., Fab-antidotal therapy for digitalis poisoning; enhanced elimination procedures, including single-pass albumin dialysis, the molecular adsorbents recirculating system (MARS™) technique, or plasma exchange therapy), which are discussed separately within the respective chapters of this textbook. Although the latter extracorporeal elimination techniques may have a role in very special settings of highly protein-bound drug-overdoses (where conventional hemodialysis fails) [46,47], it is needless to say that most of these techniques require a minimum degree of hemodynamic stability (i.e., sufficiently high CO) to be applicablea prerequisite that essentially limits their use in patients with poison-induced severe hypotension, shock, or even cardiac arrest.…”
Section: Antidotal Therapymentioning
confidence: 99%
“…The principle for their use is that by adding albumin to the dialysate, a protein‐binding disequilibrium is created where unbound drug from the blood side could bind to the albumin on the dialysate side. These techniques have been used for treatments of poisoning with varying degrees of success . Although experimental studies show clearances of endogenous molecules varying from 10 to 75 ml/minute for both MARS and Prometheus , the clearance of several drugs rarely exceeds 40 ml/minute, even at a high Q B , which is lower than what can be attainable with other ECTRs.…”
Section: Albumin Dialysismentioning
confidence: 99%