Extracorporal blood purification: more than diffusion and convection. Does this help?

Ronco, Claudio; Tetta, Ciro

doi:10.1097/mcc.0b013e3282f194c0

Cited by 9 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Porous polymer beads of different sizes and with different side chains, for example, can be used to build adsorbent columns for extracting particles within a particular molecular weight range [43,[64][65][66]. Physical modification of the size of the beads and chemical modification of the molecular side chains allow cytokines such as bacterial endotoxins and lipopolysaccharides to be targeted [43,67].…”

Section: History Of Cytokine Adsorption Therapymentioning

confidence: 99%

Clinical Utility of Extracorporeal Cytokine Hemoadsorption Therapy: A Literature Review

et al. 2018

View full text Add to dashboard Cite

Cytokines play a critical role in coordinating and amplifying a host immune response to infection. The normal pattern of localized and systemic release of proinflammatory and anti-inflammatory cytokines varies on the basis of the disease process. A dysregulated cytokine response can lead to a hyper-inflammatory condition called a cytokine storm. This is believed to contribute to the pathophysiology of sepsis and septic shock, a condition carrying high morbidity and mortality in critically ill patients. Extracorporeal cytokine hemoadsorption is an emerging technology utilized in the treatment of dysregulated inflammatory states such as sepsis, although there is a paucity of clinical evidence supporting its outcomes benefits. We assess the peer-reviewed literature relating to cytokine hemoadsorption in the context of sepsis and suggest areas of future research incorporating this novel technology.

show abstract

Section: History Of Cytokine Adsorption Therapymentioning

confidence: 99%

Clinical Utility of Extracorporeal Cytokine Hemoadsorption Therapy: A Literature Review

et al. 2018

View full text Add to dashboard Cite

show abstract

“…During the extracorporeal procedure, mechanisms removing unwanted solutes and excess fluid from blood include diffusion, convection, and/or adsorption [ 9 ]. Diffusion refers to the molecular movement of solutes from a region of greater concentration to a region of lesser concentration; it is particularly effective in removing small sized solutes into outflow dialysate fluid.…”

Section: Dialytic Solute Removalmentioning

confidence: 99%

Proteomic Investigations into Hemodialysis Therapy

Bonomini

Sirolli

Pieroni

et al. 2015

IJMS

View full text Add to dashboard Cite

The retention of a number of solutes that may cause adverse biochemical/biological effects, called uremic toxins, characterizes uremic syndrome. Uremia therapy is based on renal replacement therapy, hemodialysis being the most commonly used modality. The membrane contained in the hemodialyzer represents the ultimate determinant of the success and quality of hemodialysis therapy. Membrane’s performance can be evaluated in terms of removal efficiency for unwanted solutes and excess fluid, and minimization of negative interactions between the membrane material and blood components that define the membrane’s bio(in)compatibility. Given the high concentration of plasma proteins and the complexity of structural functional relationships of this class of molecules, the performance of a membrane is highly influenced by its interaction with the plasma protein repertoire. Proteomic investigations have been increasingly applied to describe the protein uremic milieu, to compare the blood purification efficiency of different dialyzer membranes or different extracorporeal techniques, and to evaluate the adsorption of plasma proteins onto hemodialysis membranes. In this article, we aim to highlight investigations in the hemodialysis setting making use of recent developments in proteomic technologies. Examples are presented of why proteomics may be helpful to nephrology and may possibly affect future directions in renal research.

show abstract

“…In the last decade, it has been postulated that high convective dose therapies improve the management of sepsis (16,20,(50)(51)(52)(53). Severe sepsis and septic shock are the primary causes of multiple organ dysfunction syndrome (MODS), the most frequent cause of death in ICU patients.…”

Section: Hemofiltration Of Large Moleculesmentioning

confidence: 99%

THE CLINICAL APPLICATION OF CRRT—CURRENT STATUS: Modalities of Continuous Renal Replacement Therapy: Technical and Clinical Considerations

Cerdá

Ronco

2009

Seminars in Dialysis

Self Cite

View full text Add to dashboard Cite

Continuous renal replacement therapies (CRRT) are continuous forms of renal functional replacement used to manage acute kidney injury (AKI) in the critically ill patient. Depurative mechanisms include convection, diffusion, and membrane adsorption utilizing high-flux highly permeable biocompatible dialysis membranes. The simultaneous infusion of replacement fluid permits fluid removal without intravascular volume contraction and better hemodynamic stability, metabolic control to almost normal parameters, and removal of large-size toxins and cytokines. Moreover, CRRT allows better long-term clearance of small and middle molecules than other dialysis modalities. This article focuses on the different modalities of CRRT and reviews both the basic concepts and the newest approaches to the management of the critically ill patient with AKI.

show abstract

Extracorporal blood purification: more than diffusion and convection. Does this help?

Cited by 9 publications

References 31 publications

Clinical Utility of Extracorporeal Cytokine Hemoadsorption Therapy: A Literature Review

Clinical Utility of Extracorporeal Cytokine Hemoadsorption Therapy: A Literature Review

Proteomic Investigations into Hemodialysis Therapy

THE CLINICAL APPLICATION OF CRRT—CURRENT STATUS: Modalities of Continuous Renal Replacement Therapy: Technical and Clinical Considerations

Contact Info

Product

Resources

About