Extracellular vesicles released from chronic lymphocytic leukemia cells exhibit a disease relevant mRNA signature and transfer mRNA to bystander cells

Reiners, Katrin S.; Shatnyeva, Olga; Vasyutina, Elena; Bösl, Teresa; Hansen, Hinrich P.; Hallek, Michael; Herling, Marco; Strandmann, Elke Pogge von

doi:10.3324/haematol.2016.153197

Cited by 15 publications

(14 citation statements)

References 15 publications

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“…Recently, Reiners et al applied next-generation sequencing to characterize and compare the miR content in CLL cells and B cells from healthy donors. This study confirmed that CLL-derived EVs displayed a disease-related signature and were enriched in miRs encoding for genes frequently mutated in CLL, such as B-cell receptor (BCR) kinases, apoptosis-related genes, and splicing factors [62] .…”

Section: Functional Interpretation Of Evs Content In Hmsupporting

confidence: 71%

High-throughput analysis and functional interpretation of extracellular vesicle content in hematological malignancies

Adamo

Kamga

Tanasi

et al. 2020

Computational and Structural Biotechnology Journal

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Extracellular vesicles (EVs) are membrane-coated particles secreted by virtually all cell types in response to different stimuli, both in physiological and pathological conditions . Their content generally reflects their biological functions and includes a variety of molecules, such as nucleic acids, proteins and cellular components. The role of EVs as signaling vehicles has been widely demonstrated. In particular, they are actively involved in the pathogenesis of several hematological malignancies (HM), mainly interacting with a number of target cells and inducing functional and epigenetic changes. In this regard, by releasing their cargo, EVs play a pivotal role in the bilateral cross-talk between tumor microenvironment and cancer cells, thus facilitating mechanisms of immune escape and supporting tumor growth and progression. Recent advances in high-throughput technologies have allowed the deep characterization and functional interpretation of EV content. In this review, the current knowledge on the high-throughput technology-based characterization of EV cargo in HM is summarized.

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Section: Functional Interpretation Of Evs Content In Hmsupporting

confidence: 71%

High-throughput analysis and functional interpretation of extracellular vesicle content in hematological malignancies

Adamo

Kamga

Tanasi

et al. 2020

Computational and Structural Biotechnology Journal

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“…Notably, this immune-regulatory interplay can be stopped by vitamin D, which negatively regulates miR-155 expression in CLL cells [ 119 ]. Reiners et al found that transfer mRNA molecules by CLL EV to monocytes and fibroblasts spread tumor signals within the CLL microenvironment [ 120 ]. Clearly, CLL EVs are enriched in disease-relevant mRNA, including splicing factors, the TCL1A oncogene, and tyrosine kinases [ 121 ].…”

Section: The Immune Evasion Mechanism Of Blood Cancers: Focus On Ementioning

confidence: 99%

The “Vesicular Intelligence” Strategy of Blood Cancers

Forte

Barone

Palandri

et al. 2021

Genes

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Blood cancers are a heterogeneous group of disorders including leukemia, multiple myeloma, and lymphoma. They may derive from the clonal evolution of the hemopoietic stem cell compartment or from the transformation of progenitors with immune potential. Extracellular vesicles (EVs) are membrane-bound nanovesicles which are released by cells into body fluids with a role in intercellular communication in physiology and pathology, including cancer. EV cargos are enriched in nucleic acids, proteins, and lipids, and these molecules can be delivered to target cells to influence their biological properties and modify surrounding or distant targets. In this review, we will describe the “smart strategy” on how blood cancer-derived EVs modulate tumor cell development and maintenance. Moreover, we will also depict the function of microenvironment-derived EVs in blood cancers and discuss how the interplay between tumor and microenvironment affects blood cancer cell growth and spreading, immune response, angiogenesis, thrombogenicity, and drug resistance. The potential of EVs as non-invasive biomarkers will be also discussed. Lastly, we discuss the clinical application viewpoint of EVs in blood cancers. Overall, blood cancers apply a ‘vesicular intelligence’ strategy to spread signals over their microenvironment, promoting the development and/or maintenance of the malignant clone.

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“…In conclusion, the transfer of inhibitory miRNAs or mRNAs by tumor derived-EVs can promote cancer progression by negatively influencing the host's immune response in different cancer types [100,101].…”

Section: Immunity and Extracellular Vesicles In Cancermentioning

confidence: 96%

Extracellular Vesicles and Cancer: A Focus on Metabolism, Cytokines, and Immunity

Lucchetti

Tenore

Colella

et al. 2020

Cancers

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A better understanding of the mechanisms of cell communication between cancer cells and the tumor microenvironment is crucial to develop personalized therapies. It has been known for a while that cancer cells are metabolically distinct from other non-transformed cells. This metabolic phenotype is not peculiar to cancer cells but reflects the characteristics of the tumor microenvironment. Recently, it has been shown that extracellular vesicles are involved in the metabolic switch occurring in cancer and tumor-stroma cells. Moreover, in an immune system, the metabolic programs of different cell subsets are distinctly associated with their immunological function, and extracellular vesicles could be a key factor in the shift of cell fate modulating cancer immunity. Indeed, during tumor progression, tumor-associated immune cells and fibroblasts acquire a tumor-supportive and anti-inflammatory phenotype due to their interaction with tumor cells and several findings suggest a role of extracellular vesicles in this phenomenon. This review aims to collect all the available evidence so far obtained on the role of extracellular vesicles in the modulation of cell metabolism and immunity. Moreover, we discuss the possibility for extracellular vesicles of being involved in drug resistance mechanisms, cancer progression and metastasis by inducing immune-metabolic effects on surrounding cells.

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Extracellular vesicles released from chronic lymphocytic leukemia cells exhibit a disease relevant mRNA signature and transfer mRNA to bystander cells

Cited by 15 publications

References 15 publications

High-throughput analysis and functional interpretation of extracellular vesicle content in hematological malignancies

High-throughput analysis and functional interpretation of extracellular vesicle content in hematological malignancies

The “Vesicular Intelligence” Strategy of Blood Cancers

Extracellular Vesicles and Cancer: A Focus on Metabolism, Cytokines, and Immunity

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