Extracellular vesicles—Potential link between periodontal disease and diabetic complications

Abstract

It has long been suggested that a bidirectional impact exists between periodontitis and diabetes. Periodontitis may affect diabetes glycemic control, insulin resistance, and diabetic complications. Diabetes can worsen periodontitis by delaying wound healing and increasing the chance of infection. Extracellular vesicles (EVs) are heterogeneous particles of membrane‐enclosed spherical structure secreted by eukaryotes and prokaryotes and play a key role in a variety of diseases. This review will introduce the biogenesis, release, and biological function of EVs from a microbial and host cell perspective, discuss the functional properties of EVs in the development of periodontitis and diabetes, and explore their role in the pathogenesis and clinical application of these two diseases. Their clinical implication and diagnostic value are also discussed.

Regulation of metabolism and inflammation: Links with oral and systemic health

“…Recently, extracellular vesicles (EVs), including bacterial and host-derived EVs, have emerged as crucial factors in both diseases(Cai et al, 2023). The article byHuang et al (2024) explores the origin, function, and clinical implications of EVs, focusing on their involvement in the pathogenesis of periodontitis and diabetes. The interaction between EVs and inflammatory mediators contributes to systemic complications like diabetic retinopathy and cardiovascular diseases.…”