Abstract:Background:E. coli O83 (Colinfant Newborn) is a
Gram-negative (G-) probiotic bacterium used in the clinic. When
administered orally, it reduces allergic sensitisation but not allergic
asthma. Intranasal administration may be more effective as it reaches
the lungs directly. G- bacteria release outer membrane vesicles (OMVs)
to communicate with the environment. Here we investigate whether
intranasally administered E. coli O83 OMVs (EcO83-OMVs) can
reduce allergy in mice. Methods: EcO83-OMVs were isolated by
ultr… Show more
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