Extracellular vesicles derived from Porphyromonas gingivalis induce trigeminal nerve-mediated cognitive impairment

Ma, Xiaoyang; Shin, Yoon-Jung; Yoo, Jong-Wook; Park, Hee-Seo; Kim, Dong-Hyun

doi:10.1016/j.jare.2023.02.006

Cited by 17 publications

(14 citation statements)

References 45 publications

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Section: Resultsmentioning

confidence: 99%

“…The studies providing evidence on bacterial EV passage through BBB highlights an established connection between oral health and neurodegenerative disorders ( Han et al, 2019 ; Ha et al, 2020 ; Gong et al, 2022 ; Nonaka et al, 2022 ; Pritchard et al, 2022 ; Ma et al, 2023 ). Indeed, the bacterial EV passage through BBB has been most often studied with oral pathogens, such as Porphyromonas gingivalis ( Gong et al, 2022 ; Nonaka et al, 2022 ; Pritchard et al, 2022 ; Ma et al, 2023 ) and Aggregatibacter actinomycetemcomitans ( Han et al, 2019 ; Ha et al, 2020 ). The scope of bacterial EV research regarding BBB crossing also includes diseases involving brain inflammation ( Wispelwey et al, 1989 ; Lee et al, 2020 ; Palacios et al, 2023 ; Xie et al, 2023 ), ischemic stroke ( Pan et al, 2023 ), stress ( Choi et al, 2019 , 2022 ), serotonin signaling ( Yaghoubfar et al, 2020 ) and chemotherapy ( Mi et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

“…The ability of bacterial EVs to cross the BBB has been studied in vivo using different murine models ( Wispelwey et al, 1989 ; Choi et al, 2019 , 2022 ; Han et al, 2019 ; Ha et al, 2020 ; Lee et al, 2020 ; Wei et al, 2020 ; Yaghoubfar et al, 2020 ; Bittel et al, 2021 ; Gong et al, 2022 ; Mi et al, 2022 ; Ma et al, 2023 ; Palacios et al, 2023 ; Pan et al, 2023 ; Xie et al, 2023 ) and conventional in vitro human BBB cell models employing brain endothelial cell monolayers ( Nonaka et al, 2022 ; Pritchard et al, 2022 ). The majority of the in vivo studies employ EV labeling and subsequent imaging analysis in mouse models in their study setting.…”

Section: Resultsmentioning

confidence: 99%

“…In murine models, EVs have been most often administrated by oral gavage ( Lee et al, 2020 ; Yaghoubfar et al, 2020 ; Gong et al, 2022 ; Ma et al, 2023 ) or as an injection to blood circulation ( Mi et al, 2022 ), either by intracardiac injection ( Han et al, 2019 ) or through the tail vein ( Ha et al, 2020 ; Wei et al, 2020 ; Palacios et al, 2023 ; Pan et al, 2023 ). Gong et al (2022) reported passage of Porphyromonas gingivalis EVs through BBB when administrated by oral gavage to mice when 100 μg of EVs (per EV protein) and 3 days of circulation time was used ( Gong et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

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Bacterial extracellular vesicles – brain invaders? A systematic review

Kaisanlahti,

Salmi,

Kumpula

et al. 2023

Front. Mol. Neurosci.

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IntroductionKnowledge on the human gut microbiota in health and disease continues to rapidly expand. In recent years, changes in the gut microbiota composition have been reported as a part of the pathology in numerous neurodegenerative diseases. Bacterial extracellular vesicles (EVs) have been suggested as a novel mechanism for the crosstalk between the brain and gut microbiota, physiologically connecting the observed changes in the brain to gut microbiota dysbiosis.MethodsPublications reporting findings on bacterial EVs passage through the blood–brain barrier were identified in PubMed and Scopus databases.ResultsThe literature search yielded 138 non-duplicate publications, from which 113 records were excluded in title and abstract screening step. From 25 publications subjected to full-text screening, 8 were excluded. The resulting 17 publications were considered for the review.DiscussionBacterial EVs have been described with capability to cross the blood–brain barrier, but the mechanisms behind the crossing remain largely unknown. Importantly, very little data exists in this context on EVs secreted by the human gut microbiota. This systematic review summarizes the present evidence of bacterial EVs crossing the blood–brain barrier and highlights the importance of future research on gut microbiota-derived EVs in the context of gut-brain communication across the blood–brain barrier.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Bacterial extracellular vesicles – brain invaders? A systematic review

Kaisanlahti,

Salmi,

Kumpula

et al. 2023

Front. Mol. Neurosci.

View full text Add to dashboard Cite

show abstract

“…(2) The neural migration pathway of periodontal pathogens has garnered increasing attention. Bacteria and/or their toxins could migrate to the trigeminal ganglion along the peripheral end of craniofacial nerves, such as the olfactory trigeminal nerve, and retrograde into the brain ( Riviere et al, 2002 ; Su et al, 2021 ; Ma et al, 2023 ).…”

Section: The Pathways Of Periodontal Pathogens Affecting Cnsmentioning

confidence: 99%

The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer’s disease?

Li,

Wang,

Xiong

et al. 2024

Front. Microbiol.

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Alzheimer’s disease (AD) is the most prevalent form of dementia, characterized by a progressive cognitive decline. Sporadic AD, accounting for more than 95% of cases, may arise due to the influence of environmental factors. It was reported that periodontitis, a common oral ailment, shares several risk factors with AD, including advanced age, smoking, diabetes, and hypertension, among others. Periodontitis is an inflammatory disease triggered by dysbiosis of oral microorganisms, whereas Alzheimer’s disease is characterized by neuroinflammation. Many studies have indicated that chronic inflammation can instigate brain AD-related pathologies, including amyloid-β plaques, Tau protein hyperphosphorylation, neuroinflammation, and neurodegeneration. The potential involvement of periodontal pathogens and/or their virulence factors in the onset and progression of AD by the oral-brain axis has garnered significant attention among researchers with ongoing investigations. This review has updated the periodontal pathogens potentially associated with AD, elucidating their impact on the central nervous system, immune response, and related pathological processes in the brain to provide valuable insights for future research on the oral-brain axis.

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Extracellular vesicles and endothelial dysfunction in infectious diseases

Zhang,

Chi,

et al. 2024

J of Extracellular Bio

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Cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity globally. Studies have shown that infections especially bacteraemia and sepsis are associated with increased risks for endothelial dysfunction and related CVDs including atherosclerosis. Extracellular vesicles (EVs) are small, sealed membrane‐derived structures that are released into body fluids and blood from cells and/or microbes and are critically involved in a variety of important cell functions and disease development, including intercellular communications, immune responses and inflammation. It is known that EVs‐mediated mechanism(s) is important in the development of endothelial dysfunction in infections with a diverse spectrum of microorganisms including Escherichia coli, Candida albicans, SARS‐CoV‐2 (the virus for COVID‐19) and Helicobacter pylori. H. pylori infection is one of the most common infections globally. During H. pylori infection, EVs can carry H. pylori components, such as lipopolysaccharide, cytotoxin‐associated gene A, or vacuolating cytotoxin A, and transfer these substances into endothelial cells, triggering inflammatory responses and endothelial dysfunction. This review is to illustrate the important role of EVs in the pathogenesis of infectious diseases, and the development of endothelial dysfunction in infectious diseases especially H. pylori infection, and to discuss the potential mechanisms and clinical implications.

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Extracellular vesicles derived from Porphyromonas gingivalis induce trigeminal nerve-mediated cognitive impairment

Cited by 17 publications

References 45 publications

Bacterial extracellular vesicles – brain invaders? A systematic review

Bacterial extracellular vesicles – brain invaders? A systematic review

The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer’s disease?

Extracellular vesicles and endothelial dysfunction in infectious diseases

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