Extracellular vesicles derived from human dental mesenchymal stem cells stimulated with low-intensity pulsed ultrasound alleviate inflammation-induced bone loss in a mouse model of periodontitis

Zhang, T.; Chen, Ziqi; Zhu, Mengyuan; Jing, Xuan; Xu, Xiaohui; Yuan, Xulei; Zhou, Menglong; Zhang, Yanan; Lu, Miao; Chen, Duanjing; Xu, Shihan; Song, Jinlin

doi:10.1016/j.gendis.2022.06.009

Cited by 6 publications

(6 citation statements)

References 61 publications

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“…The most recent research has reported that LIPUS can significantly reduce the expression of pro‐inflammatory cytokines and contribute to the modulation of the immune microenvironment in vivo 122–125 . In alignment with these findings, the application of LIPUS to MSC‐Exo reinforces their anti‐inflammatory effects via altering the compositions of MSC‐Exo 31,111 …”

Section: Effects Of Different Physical Factors On Msc‐exomentioning

confidence: 70%

“…[122][123][124][125] In alignment with these findings, the application of LIPUS to MSC-Exo reinforces their antiinflammatory effects via altering the compositions of MSC-Exo. 31,111 Additionally, LIPUS has been acknowledged as a potent intervention to promote cartilage regeneration and osteogenic differentiation mediated by MSC-Exo. 31,42,126 Besides, LIPUS could accelerate nerve injury repair.…”

Section: The Impact Of Lipus On Msc-exomentioning

confidence: 99%

“…31,111 Additionally, LIPUS has been acknowledged as a potent intervention to promote cartilage regeneration and osteogenic differentiation mediated by MSC-Exo. 31,42,126 Besides, LIPUS could accelerate nerve injury repair. 127,128 Interestingly, MSC-Exo also exhibit robust therapeutic potential in neurological diseases.…”

Section: The Impact Of Lipus On Msc-exomentioning

confidence: 99%

“…Physical factors can be categorized into two aspects: one pertains to the physical characteristics of internal microenvironment, such as substrate stiffness and topography, 26 , 27 , 28 , 29 while the other involves external physical stimulations, including mechanical strain, ultrasound, laser, electrical stimulation and other stimuli. 30 , 31 , 32 , 33 , 34 Although intense physical stimulation is a major factor contributing to tissue damage, 35 , 36 it can be widely used as a therapeutic approach in a variety of diseases if the parameters are properly adjusted. 37 , 38 , 39 , 40 Previous studies have demonstrated that exosomes are highly sensitive to physical factors.…”

Section: Introductionmentioning

confidence: 99%

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Physical modulation of mesenchymal stem cell exosomes: A new perspective for regenerative medicine

Wu,

Zhao,

Xie

et al. 2024

Cell Proliferation

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Mesenchymal stem cell‐derived exosomes (MSC‐Exo) offer promising therapeutic potential for various refractory diseases, presenting a novel therapeutic strategy. However, their clinical application encounters several obstacles, including low natural secretion, uncontrolled biological functions and inherent heterogeneity. On the one hand, physical stimuli can mimic the microenvironment dynamics where MSC‐Exo reside. These factors influence not only their secretion but also, significantly, their biological efficacy. Moreover, physical factors can also serve as techniques for engineering exosomes. Therefore, the realm of physical factors assumes a crucial role in modifying MSC‐Exo, ultimately facilitating their clinical translation. This review focuses on the research progress in applying physical factors to MSC‐Exo, encompassing ultrasound, electrical stimulation, light irradiation, intrinsic physical properties, ionizing radiation, magnetic field, mechanical forces and temperature. We also discuss the current status and potential of physical stimuli‐affected MSC‐Exo in clinical applications. Furthermore, we address the limitations of recent studies in this field. Based on this, this review provides novel insights to advance the refinement of MSC‐Exo as a therapeutic approach in regenerative medicine.

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Section: Effects Of Different Physical Factors On Msc‐exomentioning

confidence: 70%

Section: The Impact Of Lipus On Msc-exomentioning

confidence: 99%

Section: The Impact Of Lipus On Msc-exomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Physical modulation of mesenchymal stem cell exosomes: A new perspective for regenerative medicine

Wu,

Zhao,

Xie

et al. 2024

Cell Proliferation

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show abstract

“…The stimuli increased the secretion of EVs by promoting the expression of neutral sphingomyelinases in SCAP. In addition, EVs from LIPUS-induced SCAPs exhibited stronger efficacy in promoting the osteogenic differentiation and anti-inflammation of periodontal ligament cells and alleviating oral inflammatory bone loss in vivo via increased miR-935 [ 173 ].…”

Section: Stem Cells From the Apical Papilla (Scap)mentioning

confidence: 99%

Stem Cells and Bone Tissue Engineering

Gao,

Ruzbarsky,

Layne

et al. 2024

Life

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Segmental bone defects that are caused by trauma, infection, tumor resection, or osteoporotic fractures present significant surgical treatment challenges. Host bone autograft is considered the gold standard for restoring function but comes with the cost of harvest site comorbidity. Allograft bone is a secondary option but has its own limitations in the incorporation with the host bone as well as its cost. Therefore, developing new bone tissue engineering strategies to treat bone defects is critically needed. In the past three decades, the use of stem cells that are delivered with different scaffolds or growth factors for bone tissue engineering has made tremendous progress. Many varieties of stem cells have been isolated from different tissues for use in bone tissue engineering. This review summarizes the progress in using different postnatal stem cells, including bone marrow mesenchymal stem cells, muscle-derived stem cells, adipose-derived stem cells, dental pulp stem cells/periodontal ligament stem cells, periosteum stem cells, umbilical cord-derived stem cells, peripheral blood stem cells, urine-derived stem cells, stem cells from apical papilla, and induced pluripotent stem cells, for bone tissue engineering and repair. This review also summarizes the progress using exosomes or extracellular vesicles that are delivered with various scaffolds for bone repair. The advantages and disadvantages of each type of stem cell are also discussed and explained in detail. It is hoped that in the future, these preclinical results will translate into new regenerative therapies for bone defect repair.

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Jingle Cell Rock: Steering Cellular Activity With Low-Intensity Pulsed Ultrasound (LIPUS) to Engineer Functional Tissues in Regenerative Medicine

Marcotulli,

Barbetta,

Scarpa

et al. 2024

Ultrasound in Medicine & Biology

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Extracellular vesicles derived from human dental mesenchymal stem cells stimulated with low-intensity pulsed ultrasound alleviate inflammation-induced bone loss in a mouse model of periodontitis

Cited by 6 publications

References 61 publications

Physical modulation of mesenchymal stem cell exosomes: A new perspective for regenerative medicine

Physical modulation of mesenchymal stem cell exosomes: A new perspective for regenerative medicine

Stem Cells and Bone Tissue Engineering

Jingle Cell Rock: Steering Cellular Activity With Low-Intensity Pulsed Ultrasound (LIPUS) to Engineer Functional Tissues in Regenerative Medicine

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