Extracellular vesicles: Critical bilateral communicators in periphery-brain crosstalk in central nervous system disorders

Wang, Danning; Guan, Shaodi; Lu, Pei Jung; Li, Yali; Xu, Hui

doi:10.1016/j.biopha.2023.114354

Cited by 6 publications

(7 citation statements)

References 111 publications

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“…Generally, OMVs of pathogenic and commensal bacteria are related to distinct interactions with the host: i. OMVs of pathogenic bacteria participate in the pathological process, and ii. OMVs of commensal bacteria promote host homeostasis (47,55,79,80).…”

Section: Resultsmentioning

confidence: 99%

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Outer membrane vesicles from commensal and pathogenic anaerobic bacteria: a systematic review of literature reviews

Castro-Vargas,

Barloy-Hubler,

Acuña-Amador

2023

Preprint

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Outer membrane vesicles (OMVs) are constitutively produced by Gram-negative bacteria (GNB), those from pathogenic bacteria play key roles in pathogen-host interactions, modulating host’s immune response and promoting virulence. OMVs of commensal bacteria are fundamental in the maturation of the host immune system and to maintain intestinal homeostasis.The objective of this systematic review was to synthesize the knowledge available on literature reviews on OMVs from anaerobic GNB. The information was classified into categories: induction and biogenesis, OMVs liberation, internalization by host cells, and their interaction. The most studied OMVs are fromPorphyromonas gingivalisandBacteroidesspp.

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Section: Resultsmentioning

confidence: 99%

“…OMVs of pathogens and commensals play a pivotal role in the communication between bacteria and their eukaryotic hosts (51,55,57,79). Generally, OMVs of pathogenic and commensal bacteria are related to distinct interactions with the host: i. OMVs of pathogenic bacteria participate in the pathological process, and ii.…”

Section: B Omvs-eukaryotic Cell Interactionsmentioning

confidence: 99%

Outer membrane vesicles from commensal and pathogenic anaerobic bacteria: a systematic review of literature reviews

Castro-Vargas,

Barloy-Hubler,

Acuña-Amador

2023

Preprint

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“…OMVs of pathogens and commensals play a pivotal role in the communication between bacteria and their eukaryotic hosts (54,59,61,86). Generally, OMVs of pathogenic and commensal bacteria are related to distinct interactions with the host: i. OMVs of commensal bacteria promote host homeostasis, and ii.…”

Section: Omvs-eukaryotic Cell Interactionsmentioning

confidence: 99%

“…Generally, OMVs of pathogenic and commensal bacteria are related to distinct interactions with the host: i. OMVs of commensal bacteria promote host homeostasis, and ii. OMVs of pathogenic bacteria participate in the pathological process (49,59,86,87).…”

Section: Omvs-eukaryotic Cell Interactionsmentioning

confidence: 99%

Unveiling Oral Anaerobic Bacteria Outer Membrane Vesicles: A Comprehensive Systematic Review

Castro-Vargas,

Barloy-Hubler,

Acuña-Amador

2024

Odovtos - Int J Dent Sc

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Extracellular vesicles (EV) are spherical structures limited by membranes and shed by several cell types. Specifically, outer membrane vesicles (OMVs) are nanometric particles constitutively produced by Gram-negative bacteria (GNB) under different environmental conditions. OMVs are biologically active; they are loaded with selected lipids, polysaccharides, proteins, and even different types of nucleic acids. OMVs from pathogenic oral bacteria play key roles in pathogen-host interactions, constituting a possible link between oral health and systemic disease. OMVs participate in adhesion, invasion, and damage to cells, as well as in modulating the host's immune response, biofilm formation, and promotion of virulence. The objective of this systematic review was to collect, analyze and synthesize the knowledge available on literature reviews on OMVs of the most studied pathogenic oral anaerobic GNB. This information was classified into the following categories: induction of vesiculation and biogenesis, its liberation from the parental cell, content, internalization by another host cell, and the interaction with the host cell. It was found that the most studied OMVs are those of Porphyromonas gingivalis and Bacteroides spp. and, to a lesser extent, Aggregatibacter spp., and Treponema spp. This systematic review provides a synthesis of the current knowledge regarding OMVs, with emphasis on the information available for periodontopathogens.

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“…They play an important role in brain-periphery communication in physiology and pathophysiology. According to the current literature, although EVs cross the BBB, it is unclear how, where, and when they can overcome this tightly controlled cellular barrier [7].…”

Section: Introductionmentioning

confidence: 99%

Extracellular Vesicles in the Central Nervous System: A Novel Mechanism of Neuronal Cell Communication

Filannino,

Panaro,

Benameur

et al. 2024

IJMS

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Cell-to-cell communication is essential for the appropriate development and maintenance of homeostatic conditions in the central nervous system. Extracellular vesicles have recently come to the forefront of neuroscience as novel vehicles for the transfer of complex signals between neuronal cells. Extracellular vesicles are membrane-bound carriers packed with proteins, metabolites, and nucleic acids (including DNA, mRNA, and microRNAs) that contain the elements present in the cell they originate from. Since their discovery, extracellular vesicles have been studied extensively and have opened up new understanding of cell–cell communication; they may cross the blood–brain barrier in a bidirectional way from the bloodstream to the brain parenchyma and vice versa, and play a key role in brain–periphery communication in physiology as well as pathology. Neurons and glial cells in the central nervous system release extracellular vesicles to the interstitial fluid of the brain and spinal cord parenchyma. Extracellular vesicles contain proteins, nucleic acids, lipids, carbohydrates, and primary and secondary metabolites. that can be taken up by and modulate the behaviour of neighbouring recipient cells. The functions of extracellular vesicles have been extensively studied in the context of neurodegenerative diseases. The purpose of this review is to analyse the role extracellular vesicles extracellular vesicles in central nervous system cell communication, with particular emphasis on the contribution of extracellular vesicles from different central nervous system cell types in maintaining or altering central nervous system homeostasis.

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Extracellular vesicles: Critical bilateral communicators in periphery-brain crosstalk in central nervous system disorders

Cited by 6 publications

References 111 publications

Outer membrane vesicles from commensal and pathogenic anaerobic bacteria: a systematic review of literature reviews

Outer membrane vesicles from commensal and pathogenic anaerobic bacteria: a systematic review of literature reviews

Unveiling Oral Anaerobic Bacteria Outer Membrane Vesicles: A Comprehensive Systematic Review

Extracellular Vesicles in the Central Nervous System: A Novel Mechanism of Neuronal Cell Communication

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