Extracellular Vesicles as Regulators of the Extracellular Matrix

Patel, Neil; Ashraf, Anisa; Chung, Eun Ji

doi:10.3390/bioengineering10020136

Cited by 23 publications

(17 citation statements)

References 87 publications

(110 reference statements)

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“…The pro-angiogenic stimulation of MVs is particularly relevant during the early stages of wound healing, but may become less important in later stages of the process (Iruela-Arispe & Dvorak, 1997). Furthermore, the binding of MVs to type I collagen suggests that MVs may potentially serve as a reservoir of intercellular signals for nearby cells, such as dermal fibroblasts, promoting ECM remodelling as previously suggested (Al Halawani et al, 2022;Patel et al, 2023;Rilla et al, 2019). For example, EVs anchored to the urinary bladder ECM have been shown to suppress pro-inflammatory signalling (Van Der Merwe et al, 2019;Zhang et al, 2013).…”

Section:  Discussionmentioning

confidence: 77%

The diffusion of normal skin wound myofibroblast‐derived microvesicles differs according to matrix composition

Arif,

Larochelle,

Trudel

et al. 2023

J of Extracellular Bio

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Microvesicles (MVs) are a subtype of extracellular vesicles that can transfer biological information over long distances, affecting normal and pathological processes including skin wound healing. However, the diffusion of MVs into tissues can be impeded by the extracellular matrix (ECM). We investigated the diffusion of dermal wound myofibroblast‐derived MVs into the ECM by using hydrogels composed of different ECM molecules such as fibrin, type III collagen and type I collagen that are present during the healing process. Fluorescent MVs mixed with hydrogels were employed to detect MV diffusion using fluorometric methods. Our results showed that MVs specifically bound type I collagen and diffused freely out of fibrin and type III collagen. Further analysis using flow cytometry and specific inhibitors revealed that MVs bind to type I collagen via the α2β1 integrin. These data demonstrate that MV transport depends on the composition of the wound environment.

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Section:  Discussionmentioning

confidence: 77%

The diffusion of normal skin wound myofibroblast‐derived microvesicles differs according to matrix composition

Arif,

Larochelle,

Trudel

et al. 2023

J of Extracellular Bio

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“…79 Exosomes carry annexins, MMPs, and heparinase, which regulate the ECM process. 80 In CRC, tumor-cellderived exosomal miRNA-10 promotes the development of cancer-associated fibroblasts (CAFs). 81 CAFs are associated with the remodeling of the extracellular stromal matrix and promote metastasis.…”

Section: Exosomes In Crc Ecm Remodelingmentioning

confidence: 99%

“…During cancer, ECM modification plays a vital role in metastasis. , In cancer, EVs have a significant role in ECM modification . Exosomes carry annexins, MMPs, and heparinase, which regulate the ECM process . In CRC, tumor-cell-derived exosomal miRNA-10 promotes the development of cancer-associated fibroblasts (CAFs) .…”

Section: Exosomes In Crc Ecm Remodelingmentioning

confidence: 99%

Clinical Impact of Exosomes in Colorectal Cancer Metastasis

Ghosh¹,

Dhar

Shivji

et al. 2023

ACS Appl. Bio Mater.

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Cancer is a complex deadly disease that has caused a global health crisis in recent epochs. Colorectal cancer (CRC) is the third most common malignant gastrointestinal disease. It has led to high mortality due to early diagnostic failure. Extracellular vesicles (EVs) come with promising solutions for CRC. Exosomes (a subpopulation of EVs) play a vital role as signaling molecules in CRC tumor microenvironment. It is secreted from all active cells. Exosome-based molecular transport (DNA, RNA, proteins, lipids, etc.) transforms the recipient cell’s nature. In CRC, tumor cell-derived exosomes (TEXs) regulate multiple events of CRC development and progression such as immunogenic suppression, angiogenesis, epithelial–mesenchymal transitions (EMT), physical changes in the extracellular matrix (ECM), and metastasis. Biofluid-circulated tumor-derived exosomes (TEXs) are a potential tool for CRC liquid biopsy. Exosome-based colorectal cancer detection creates a great impact in CRC biomarker research. The exosome-associated CRC theranostics approach is a state-of-the-art method. In this review, we address the CRC and exosomes complex associated with cancer development and progression, the impact of exosomes on CRC screening (diagnostic and prognostic biomarkers), and also highlight several exosomes with CRC clinical trials, as well as future directions of exosome-based CRC research. Hopefully, it will encourage several researchers to develop a potential exosome-based theranostic tool to fight CRC.

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“…ECM, the physical scaffold, plays a pivotal role not only in the communication of cells with nearby cells but also in the growth, function, and movement of cells [ 166 , 167 , 168 ]. Tumor cells often communicate with the ECM via the release of EVs [ 169 , 170 ]. For example, surface heparan sulfate (sHS)-positive EVs from MM cells bind to one ECM component, fibronectin, thereby acting as a ligand for sHS-positive target cells.…”

Section: Evs In Cell-cell and Cell-extracellular Matrix Communication...mentioning

confidence: 99%

The Role of Extracellular Vesicles in the Pathogenesis of Hematological Malignancies: Interaction with Tumor Microenvironment; a Potential Biomarker and Targeted Therapy

2023

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The tumor microenvironment (TME) plays an important role in the development and progression of hematological malignancies. In recent years, studies have focused on understanding how tumor cells communicate within the TME. In addition to several factors, such as growth factors, cytokines, extracellular matrix (ECM) molecules, etc., a growing body of evidence has indicated that extracellular vesicles (EVs) play a crucial role in the communication of tumor cells within the TME, thereby contributing to the pathogenesis of hematological malignancies. The present review focuses on how EVs derived from tumor cells interact with the cells in the TME, such as immune cells, stromal cells, endothelial cells, and ECM components, and vice versa, in the context of various hematological malignancies. EVs recovered from the body fluids of cancer patients often carry the bioactive molecules of the originating cells and hence can be considered new predictive biomarkers for specific types of cancer, thereby also acting as potential therapeutic targets. Here, we discuss how EVs influence hematological tumor progression via tumor–host crosstalk and their use as biomarkers for hematological malignancies, thereby benefiting the development of potential therapeutic targets.

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Extracellular Vesicles as Regulators of the Extracellular Matrix

Cited by 23 publications

References 87 publications

The diffusion of normal skin wound myofibroblast‐derived microvesicles differs according to matrix composition

The diffusion of normal skin wound myofibroblast‐derived microvesicles differs according to matrix composition

Clinical Impact of Exosomes in Colorectal Cancer Metastasis

The Role of Extracellular Vesicles in the Pathogenesis of Hematological Malignancies: Interaction with Tumor Microenvironment; a Potential Biomarker and Targeted Therapy

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