Extracellular Vesicles as Delivery Shippers for Noncoding RNA‐Based Modulation of Angiogenesis: Insights from Ischemic Stroke and Cancer

Pan, Yongli; Liu, Yuheng; Wei, Wei; Wang, Zengguang; Yang, Xinyu

doi:10.1002/smll.202205739

Cited by 9 publications

(3 citation statements)

References 319 publications

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“…Cancer-related exosomes, released by cancer cells and other cells in the tumor micro-environment, play regulatory roles in the progression, migration, and deterioration of multiple cancers ( Sandua et al, 2021 ). CircRNAs can be a novel type of therapeutic targets, by functioning as tumor suppressors or oncogenes ( He et al, 2021 ; Pan et al, 2023 ). Accumulated studies have revealed that cancer cells could release circRNAs to the surrounding recipient cells via exosome-mediated transport strategies, thus affecting the carcinogenesis and therapeutic response ( Liu et al, 2021b ; Fontemaggi et al, 2021 ; Zhang et al, 2023 ).…”

Section: Discussion and Perspectivementioning

confidence: 99%

Unraveling the significance of exosomal circRNAs in cancer therapeutic resistance

Kang

Yan²,

Liu³

et al. 2023

Front. Pharmacol.

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Exosomes are nanoscale extracellular vesicles secreted by a variety of cells, affecting the physiological and pathological homeostasis. They carry various cargoes including proteins, lipids, DNA, and RNA and have emerged as critical mediators of intercellular communication. During cell–cell communication, they can internalize either by autologous or heterologous recipient cells, which activate different signaling pathways, facilitating malignant progression of cancer. Among different types of cargoes in exosomes, the endogenous non-coding RNAs, such as circular RNAs (or circRNAs), have gained tremendous attention for their high stability and concentration, playing promising functional roles in cancer chemotherapeutic response by regulating the targeted gene expression. In this review, we primarily described the emerging evidence demonstrating the important roles of circular RNAs derived from exosomes in the regulation of cancer-associated signaling pathways that were involved in cancer research and therapeutic interventions. Additionally, the relevant profiles of exosomal circRNAs and their biological implications have been discussed, which is under investigation for their potential effect on the control of cancer therapeutic resistance.

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Section: Discussion and Perspectivementioning

confidence: 99%

Unraveling the significance of exosomal circRNAs in cancer therapeutic resistance

Kang

Yan²,

Liu³

et al. 2023

Front. Pharmacol.

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show abstract

“…Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), which are encapsulated in EVs, are involved in AS and VC [ 76 , 77 ]. ncRNAs shuttled via EVs may control post-hypoxia tissue survival and remodeling by regulating cell injury and inflammatory responses in MI and stroke [ 78 , 79 ]. Cardiomyocytes increase the secretion of EVs during stress, such as hypoxia, inflammation, or injury [ 80 ].…”

Section: Evs In Atherosclerosis and Cardiovascular Diseasesmentioning

confidence: 99%

Extracellular Vesicles in Atherosclerosis: State of the Art

Olejarz,

Sadowski,

Radoszkiewicz

2023

IJMS

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Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation in the arteries, leading to narrowing and thrombosis that causes mortality. Emerging evidence has confirmed that atherosclerosis affects younger people and is involved in the majority of deaths worldwide. EVs are associated with critical steps in atherosclerosis, cholesterol metabolism, immune response, endothelial dysfunction, vascular inflammation, and remodeling. Endothelial cell-derived EVs can interact with platelets and monocytes, thereby influencing endothelial dysfunction, atherosclerotic plaque destabilization, and the formation of thrombus. EVs are potential diagnostic and prognostic biomarkers in atherosclerosis (AS) and cardiovascular disease (CVD). Importantly, EVs derived from stem/progenitor cells are essential mediators of cardiogenesis and cardioprotection and may be used in regenerative medicine and tissue engineering.

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“…LncRNA enrichment in EVs has been extensively studied in various contexts, including tumors (Geng et al, 2023; Wu et al, 2023), cardiovascular diseases (Jiapaer et al, 2023), diabetes mellitus (Gauthier et al, 2022), ischemic stroke (Pan et al, 2023), and Alzheimer's (Canseco‐Rodriguez et al, 2022), among others. However, studies that concentrate on exosomal lncRNAs in parasitology are few.…”

Section: Lncrnas In Malariamentioning

confidence: 99%

Exosome‐derived long noncoding RNAs: Mediators of host–Plasmodium parasite communication

et al. 2023

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Overcoming challenges associated with malaria eradication proves to be a formidable task due to the complicated life cycle exhibited by the malaria parasite and the lack of safe and enduring vaccines against malaria. Investigating the interplay between Plasmodium parasites and their mammalian hosts is crucial for the development of novel vaccines. Long noncoding RNAs (lncRNAs) derived from Plasmodium parasites or host cells have emerged as potential signaling molecules involved in the trafficking of proteins, RNA (mRNAs, miRNAs, and ncRNAs), and DNA. These lncRNAs facilitate the interaction between hosts and parasites, impacting normal physiology or pathology in malaria‐infected individuals. Moreover, they possess the capacity to regulate immune responses and associated signaling pathways, thus potentially influencing chromatin organization, epigenetic modifications, mRNA processing, splicing, and translation. However, the functional role of exosomal lncRNAs in malaria remains poorly understood. This review offers a comprehensive analysis of lncRNA and exosomal lncRNA profiles during malaria infection. It presents an overview of recent progress in elucidating the involvement of exosomal lncRNAs in host–parasite interactions. Additionally, potential exosomal lncRNAs linked to the domains of innate and adaptive immunity in the context of malaria are proposed. These findings may contribute to the discovery of new diagnostic and therapeutic strategies for malaria. Furthermore, the need for additional research was highlighted that aimed to elucidate the mechanisms underlying lncRNA transportation into host cells and their targeting of specific genes to regulate the host's immune response. This knowledge gap presents an opportunity for future investigations, offering innovative approaches to enhance malarial control.This article is categorized under: RNA Interactions with Proteins and Other Molecules > Small Molecule‐RNA Interactions RNA Interactions with Proteins and Other Molecules > Protein‐RNA Interactions: Functional Implications RNA in Disease and Development > RNA in Disease

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Extracellular Vesicles as Delivery Shippers for Noncoding RNA‐Based Modulation of Angiogenesis: Insights from Ischemic Stroke and Cancer

Cited by 9 publications

References 319 publications

Unraveling the significance of exosomal circRNAs in cancer therapeutic resistance

Unraveling the significance of exosomal circRNAs in cancer therapeutic resistance

Extracellular Vesicles in Atherosclerosis: State of the Art

Exosome‐derived long noncoding RNAs: Mediators of host–Plasmodium parasite communication

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