Extracellular vesicles as carriers of mRNA: Opportunities and challenges in diagnosis and treatment
Robert D. Kirian,
Darby Steinman,
Christopher M. Jewell
et al.
Abstract:Extracellular vesicles (EVs) are produced by all cells in the body. These biological nanoparticles facilitate cellular communication through the transport of diverse cargoes, including small molecules, proteins, and nucleic acids. mRNA cargoes have gained particular interest given their role in the translation of functional proteins. As a biomarker platform, EVs can be found in nearly all biofluids—blood, mucus, urine, cerebrospinal fluid, and saliva—providing real-time insight into parent cell and tissue func… Show more
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