Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance

Vasconcelos, M. Helena; Caires, Hugo R.; Ābols, Artūrs; Xavier, Cristina P.R.; Linē, Aija

doi:10.1016/j.drup.2019.100647

Cited by 117 publications

(114 citation statements)

References 248 publications

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“…In conclusion, EVs represent an ideal source of diagnostic and prognostic biomarkers for liquid biopsy [277,278]. Given their ability to pass through biological barriers, EVs, which are easily obtainable from accessible biological fluids, such as tears, blood, and/or urine, can provide valuable information about pathophysiological conditions that affect organs or systems that are inaccessible or not easily accessible to direct biological sampling, such as CNS, kidneys, and embryo-fetal placental tissues.…”

Section: Resultsmentioning

confidence: 99%

Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers

Simeone

Bologna

Lanuti

et al. 2020

IJMS

140

117

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Extracellular vesicles act as shuttle vectors or signal transducers that can deliver specific biological information and have progressively emerged as key regulators of organized communities of cells within multicellular organisms in health and disease. Here, we survey the evolutionary origin, general characteristics, and biological significance of extracellular vesicles as mediators of intercellular signaling, discuss the various subtypes of extracellular vesicles thus far described and the principal methodological approaches to their study, and review the role of extracellular vesicles in tumorigenesis, immunity, non-synaptic neural communication, vascular-neural communication through the blood-brain barrier, renal pathophysiology, and embryo-fetal/maternal communication through the placenta.

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Section: Resultsmentioning

confidence: 99%

Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers

Simeone

Bologna

Lanuti

et al. 2020

IJMS

140

117

View full text Add to dashboard Cite

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“…More recently, extracellular vesicles (EVs) have been associated with MM growth, progression and drug resistance [145,[258][259][260]. EVs are secreted by different cell types and transport important molecules in their cargo, mediating intercellular communication [261][262][263][264]. In MM, EVs may be secreted by MM cells or by other cells in the tumor microenvironment.…”

Section: Tumor Microenvironmentmentioning

confidence: 99%

Multiple Myeloma: Available Therapies and Causes of Drug Resistance

Pinto

Bergantim

Caires

et al. 2020

Cancers

Self Cite

158

138

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Multiple myeloma (MM) is the second most common blood cancer. Treatments for MM include corticosteroids, alkylating agents, anthracyclines, proteasome inhibitors, immunomodulatory drugs, histone deacetylase inhibitors and monoclonal antibodies. Survival outcomes have improved substantially due to the introduction of many of these drugs allied with their rational use. Nonetheless, MM patients successively relapse after one or more treatment regimens or become refractory, mostly due to drug resistance. This review focuses on the main drugs used in MM treatment and on causes of drug resistance, including cytogenetic, genetic and epigenetic alterations, abnormal drug transport and metabolism, dysregulation of apoptosis, autophagy activation and other intracellular signaling pathways, the presence of cancer stem cells, and the tumor microenvironment. Furthermore, we highlight the areas that need to be further clarified in an attempt to identify novel therapeutic targets to counteract drug resistance in MM patients.

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“…Besides, the mechanism of hypoxia in vivo might be quite different with that of in vitro models. Some other factors may also stimulate the release of exosomes including thermal stress, oxidative stress, tumor pH value, autophagy, endoplasmic reticulum stress, increase in intracellular Ca 2+ levels, or drug intervention [122]. Therefore, circulating exosome quantification has many limitations due to its non-specificity.…”

Section: Clinical Applicationsmentioning

confidence: 99%

Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment

Wang

Han

et al. 2020

J Hematol Oncol

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Exosomes are small extracellular vesicles secreted by almost all the cells. Molecular cargos of exosomes can partially reflect the characteristics of originating cells. Exosome-mediated cell-to-cell interactions in the microenvironment are critical in cancer progression. Hypoxia, a key pro-cancerous feature of the tumor microenvironment, alters the releasing and contents of exosomes. A growing body of evidence shows that hypoxia induces more aggressive phenotypes in cancer. Of note, non-coding RNAs shuttled in hypoxic tumor-derived exosomes have been demonstrated as fundamental molecules in regulating cancer biology and remodeling tumor microenvironment. Furthermore, these hypoxic tumor-derived exosomal non-coding RNAs can be detected in the body fluids, serving as promising diagnostic and prognostic biomarkers. The current review discusses changes in cancer behaviors regulated by exosomes-secreted non-coding RNAs under hypoxic conditions.

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Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance

Cited by 117 publications

References 248 publications

Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers

Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers

Multiple Myeloma: Available Therapies and Causes of Drug Resistance

Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment

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