Extracellular vesicles and microRNAs in the regulation of cardiomyocyte differentiation and proliferation

Minakawa, Tomohiro; Yamashita, Jun K.

doi:10.1016/j.abb.2023.109791

Cited by 2 publications

(1 citation statement)

References 55 publications

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“…Secreted miRNAs importantly contribute to intercellular crosstalk [210,211] and the regulation of several physiological and pathological processes [212,213], including inflammation [153]. Moreover, circulating miRNAs can be detected in body fluids and thus may represent novel non-invasive biomarkers for a wide range of human diseases [214].…”

Section: Circulating Micrornasmentioning

confidence: 99%

MiRNAs in Alcohol-Related Liver Diseases and Hepatocellular Carcinoma: A Step toward New Therapeutic Approaches?

Jouve,

Carpentier,

Kraiem

et al. 2023

Cancers

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Alcohol-related Liver Disease (ALD) is the primary cause of chronic liver disorders and hepatocellular carcinoma (HCC) development in developed countries and thus represents a major public health concern. Unfortunately, few therapeutic options are available for ALD and HCC, except liver transplantation or tumor resection for HCC. Deciphering the molecular mechanisms underlying the development of these diseases is therefore of major importance to identify early biomarkers and to design efficient therapeutic options. Increasing evidence indicate that epigenetic alterations play a central role in the development of ALD and HCC. Among them, microRNA importantly contribute to the development of this disease by controlling the expression of several genes involved in hepatic metabolism, inflammation, fibrosis, and carcinogenesis at the post-transcriptional level. In this review, we discuss the current knowledge about miRNAs’ functions in the different stages of ALD and their role in the progression toward carcinogenesis. We highlight that each stage of ALD is associated with deregulated miRNAs involved in hepatic carcinogenesis, and thus represent HCC-priming miRNAs. By using in silico approaches, we have uncovered new miRNAs potentially involved in HCC. Finally, we discuss the therapeutic potential of targeting miRNAs for the treatment of these diseases.

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