Extracellular Vesicles: a Promising cell-free Therapy for Cartilage Repair

Amsar, Rizka Musdalifah; Wijaya, C. Hanny; Ana, Ika Dewi; Hidajah, Atik Choirul; Notobroto, Hari Basuki; Wungu, Triati Dewi Kencana; Barlian, Anggraini

doi:10.2144/fsoa-2021-0096

Cited by 13 publications

(13 citation statements)

References 120 publications

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“…MSC-derived exosomes are suitable candidates for repairing degenerated discs by maintaining homeostasis. To obtain the desired therapeutic effects, they can also be engineered and loaded with biomaterials to control the release in the targeted tissue [167]. Even though many previous results have demonstrated the promising therapeutic potential of MSC-derived exosomes, special attention should be given before using them in clinical trials [168].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Exosomes and Intervertebral Disc Regeneration: Review

Bhujel

Shin

Choi

et al. 2022

IJMS

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Intervertebral disc degeneration (IVDD) is a common cause of lower back pain (LBP), which burdens individuals and society as a whole. IVDD occurs as a result of aging, mechanical trauma, lifestyle factors, and certain genetic abnormalities, leads to loss of nucleus pulposus, alteration in the composition of the extracellular matrix, excessive oxidative stress, and inflammation in the intervertebral disc. Pharmacological and surgical interventions are considered a boon for the treatment of IVDD, but the effectiveness of those strategies is limited. Mesenchymal stem cells (MSCs) have recently emerged as a possible promising regenerative therapy for IVDD due to their paracrine effect, restoration of the degenerated cells, and capacity for differentiation into disc cells. Recent investigations have shown that the pleiotropic effect of MSCs is not related to differentiation capacity but is mediated by the secretion of soluble paracrine factors. Early studies have demonstrated that MSC-derived exosomes have therapeutic potential for treating IVDD by promoting cell proliferation, tissue regeneration, modulation of the inflammatory response, and reduced apoptosis. This paper highlights the current state of MSC-derived exosomes in the field of treatment of IVDD with further possible future developments, applications, and challenges.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Exosomes and Intervertebral Disc Regeneration: Review

Bhujel

Shin

Choi

et al. 2022

IJMS

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“…Although embryonic and fetal stem cells have the greatest potential to differentiate into different cell types, their application is limited due to ethical and safety issues [ 5 , 6 , 7 , 8 , 9 , 10 ], as well as the danger of unlimited and uncontrolled cells division [ 7 , 8 , 10 , 11 , 12 , 13 , 14 , 15 ]. Furthermore, the inherent heterogenicity and variation associated with cell expansion has become a major MSC limit for its clinical applications [ 16 , 17 , 18 , 19 , 20 ]. In addition, during in vitro cell processing and expansion, changes may occur to MSCs, thereby increasing the risk of MSC therapeutic application.…”

Section: Introductionmentioning

confidence: 99%

“…At this point, exosomes are nano-sized vesicular particles commonly secreted from eukaryotic cells into the extracellular space, and are intensively investigated as candidate therapeutic agents. These exosomes have known functions in cellular communication [ 19 , 20 , 21 , 22 ], nutrients [ 21 , 22 ], bioactive compounds delivery [ 19 , 20 , 22 ], and cellular immunity [ 19 , 20 , 22 ]. However, currently, there is no standardized procedure for the isolation, storage, and manufacturing of technology using a quality system for the safety of both donors and recipients in large-scale valorization of MSC-derived exosomes [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Plant-Derived Exosome-like Nanoparticles for Biomedical Applications and Regenerative Therapy

et al. 2023

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Plant-derived exosome-like nanoparticles (PDENs) comprise various bioactive biomolecules. As an alternative cell-free therapeutic approach, they have the potential to deliver nano-bioactive compounds to the human body, and thus lead to various anti-inflammatory, antioxidant, and anti-tumor benefits. Moreover, it is known that Indonesia is one of the herbal centers of the world, with an abundance of unexplored sources of PDENs. This encouraged further research in biomedical science to develop natural richness in plants as a source for human welfare. This study aims to verify the potential of PDENs for biomedical purposes, especially for regenerative therapy applications, by collecting and analyzing data from the latest relevant research and developments.

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“…In fact, the most pursued objective in EVs biomarker discovery is the diagnosis of early-stage diseases by circulating vesicles from blood, urine or plasma, referred to as “liquid-biopsy”, as easily accessible biological fluids [ 40 ]. Furthermore, EVs also possess a powerful therapeutic potential as they could be used as direct therapeutics or loaded with active pharmaceutical molecules [ 41 , 42 , 43 , 44 , 45 ]. These potentialities culminate in the development of promising novel technologies such as outer membrane vesicles (OMVs)-based vaccines, consisting of naturally released vesicles from Gram-negative bacteria containing key antigenic components required to elicit a protective immune response [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

Multi-Omics Integrative Approach of Extracellular Vesicles: A Future Challenging Milestone

et al. 2022

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In the era of multi-omic sciences, dogma on singular cause-effect in physio-pathological processes is overcome and system biology approaches have been providing new perspectives to see through. In this context, extracellular vesicles (EVs) are offering a new level of complexity, given their role in cellular communication and their activity as mediators of specific signals to target cells or tissues. Indeed, their heterogeneity in terms of content, function, origin and potentiality contribute to the cross-interaction of almost every molecular process occurring in a complex system. Such features make EVs proper biological systems being, therefore, optimal targets of omic sciences. Currently, most studies focus on dissecting EVs content in order to either characterize it or to explore its role in various pathogenic processes at transcriptomic, proteomic, metabolomic, lipidomic and genomic levels. Despite valuable results being provided by individual omic studies, the categorization of EVs biological data might represent a limit to be overcome. For this reason, a multi-omic integrative approach might contribute to explore EVs function, their tissue-specific origin and their potentiality. This review summarizes the state-of-the-art of EVs omic studies, addressing recent research on the integration of EVs multi-level biological data and challenging developments in EVs origin.

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Extracellular Vesicles: a Promising cell-free Therapy for Cartilage Repair

Cited by 13 publications

References 120 publications

Mesenchymal Stem Cell-Derived Exosomes and Intervertebral Disc Regeneration: Review

Mesenchymal Stem Cell-Derived Exosomes and Intervertebral Disc Regeneration: Review

Plant-Derived Exosome-like Nanoparticles for Biomedical Applications and Regenerative Therapy

Multi-Omics Integrative Approach of Extracellular Vesicles: A Future Challenging Milestone

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