Extracellular Vesicles: A Double-Edged Sword in Sepsis

Burgelman, Marlies; Vandendriessche, Charysse; Vandenbroucke, Roosmarijn E.

doi:10.3390/ph14080829

Cited by 35 publications

(33 citation statements)

References 132 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The activation of exocytosis and shedding results in an increase in the quantity of so-called extravascular vesicles (EVs) into blood or other extracellular fluids ( Figure 3 ). EVs consist of exosomes (∼40–200 nm), microvesicles (∼200–1,000 nm), and apoptotic bodies (500–3,000 nm), a nomenclature based on the biogenesis pathways ( 101 ).…”

Section: Mechanisms Of Membrane Repairmentioning

confidence: 99%

“…The role of EVs in sepsis is controversial; it has been associated with both the proinflammatory ( 102 , 104 ) and anti-inflammatory ( 105 ) effects. The literature on metabolic effects of EVs in sepsis was recently reviewed in detail by Burgelman et al ( 101 ). Intriguingly, in septic patients, significantly higher levels of endothelial-derived EVs were determined in the blood of survivors compared to non-survivors ( 106 ).…”

Section: Mechanisms Of Membrane Repairmentioning

confidence: 99%

See 1 more Smart Citation

Pathogenesis of Multiple Organ Failure: The Impact of Systemic Damage to Plasma Membranes

Kozlov

Grillari

2022

Front. Med.

View full text Add to dashboard Cite

Multiple organ failure (MOF) is the major cause of morbidity and mortality in intensive care patients, but the mechanisms causing this severe syndrome are still poorly understood. Inflammatory response, tissue hypoxia, immune and cellular metabolic dysregulations, and endothelial and microvascular dysfunction are the main features of MOF, but the exact mechanisms leading to MOF are still unclear. Recent progress in the membrane research suggests that cellular plasma membranes play an important role in key functions of diverse organs. Exploration of mechanisms contributing to plasma membrane damage and repair suggest that these processes can be the missing link in the development of MOF. Elevated levels of extracellular phospholipases, reactive oxygen and nitrogen species, pore-forming proteins (PFPs), and dysregulation of osmotic homeostasis occurring upon systemic inflammatory response are the major extracellular inducers of plasma membrane damage, which may simultaneously operate in different organs causing their profound dysfunction. Hypoxia activates similar processes, but they predominantly occur within the cells targeting intracellular membrane compartments and ultimately causing cell death. To combat the plasma membrane damage cells have developed several repair mechanisms, such as exocytosis, shedding, and protein-driven membrane remodeling. Analysis of knowledge on these mechanisms reveals that systemic damage to plasma membranes may be associated with potentially reversible MOF, which can be quickly recovered, if pathological stimuli are eliminated. Alternatively, it can be transformed in a non-resolving phase, if repair mechanisms are not sufficient to deal with a large damage or if the damage is extended to intracellular compartments essential for vital cellular functions.

show abstract

Section: Mechanisms Of Membrane Repairmentioning

confidence: 99%

Section: Mechanisms Of Membrane Repairmentioning

confidence: 99%

Pathogenesis of Multiple Organ Failure: The Impact of Systemic Damage to Plasma Membranes

Kozlov

Grillari

2022

Front. Med.

View full text Add to dashboard Cite

show abstract

“…Current studies on EV secretion kinetics during different stages of sepsis are still poorly investigated. The EVs characterization with the development stage with a specific type of EVs would be further investigated ( Burgelman et al., 2021 ). Due to the heterogenous of components, sources and recipient cells of EVs, the clinical applications for the therapeutic dose and route of administration of EVs require extensive exploration ( Abreu et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…The EVs from sepsis patients may also contain histones, which are actually nuclear proteins that pack the nuclear DNA into chromatin ( Marino-Ramirez et al., 2005 ; Burgelman et al., 2021 ). The EVs containing histones released by mouse-derived BMDM interact with TLR4, displaying pro-inflammatory effect, which can promote the production of TNF, IL-6 and IL-1β, thereby increasing the lethality of sepsis ( Xu et al., 2009 ; Nair et al., 2018 ; Burgelman et al., 2021 ; Li Y. et al., 2021 ). HMGB1 represents another type of protein displaying pro-inflammatory effect in sepsis disease.…”

Section: The Role Of Ev Contents In Sepsis and Ardsmentioning

confidence: 99%

“…In addition, the surface of EVs can also bind various cytokines such as IL-1β, IL-18, GRO-α, IP-10, M-CSF, MCP-1, etc. These EVs surface cytokines are able to increase local cytokine levels, which have important implications regarding inflammatory processes ( Fitzgerald et al., 2018 ; Burgelman et al., 2021 ). ARDS is a severe hypoxic respiratory failure caused by pneumonia, sepsis, trauma and other risk factors.…”

Section: The Role Of Ev Contents In Sepsis and Ardsmentioning

confidence: 99%

See 1 more Smart Citation

Extracellular Vesicles, New Players in Sepsis and Acute Respiratory Distress Syndrome

Jing

Wang

Zhan

et al. 2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Sepsis refers to a complex syndrome associated with physiological, pathological, and biochemical abnormalities resulted from infection. Sepsis is the major cause of acute respiratory distress syndrome (ARDS). Extracellular vesicles (EVs) are serving as new messengers to mediate cell-cell communication in vivo. Non-coding RNAs, proteins and metabolites encapsulated by EVs could result in either pro-inflammatory or anti-inflammatory effects in the recipient cells. Pathogens or host cells derived EVs play an important role in pathogens infection during the occurrence and development of sepsis and ARDS. Additionally, we summarize the potential application for EVs in diagnosis, prevention and treatment for sepsis and ARDS.

show abstract

Engineered Extracellular Vesicles Derived from Dermal Fibroblasts Attenuate Inflammation in a Murine Model of Acute Lung Injury

et al. 2023

View full text Add to dashboard Cite

Acute respiratory distress syndrome (ARDS) represents a significant burden to the healthcare system, with ≈200 000 cases diagnosed annually in the USA. ARDS patients suffer from severe refractory hypoxemia, alveolar‐capillary barrier dysfunction, impaired surfactant function, and abnormal upregulation of inflammatory pathways that lead to intensive care unit admission, prolonged hospitalization, and increased disability‐adjusted life years. Currently, there is no cure or FDA‐approved therapy for ARDS. This work describes the implementation of engineered extracellular vesicle (eEV)‐based nanocarriers for targeted nonviral delivery of anti‐inflammatory payloads to the inflamed/injured lung. The results show the ability of surfactant protein A (SPA)‐functionalized IL‐4‐ and IL‐10‐loaded eEVs to promote intrapulmonary retention and reduce inflammation, both in vitro and in vivo. Significant attenuation is observed in tissue damage, proinflammatory cytokine secretion, macrophage activation, influx of protein‐rich fluid, and neutrophil infiltration into the alveolar space as early as 6 h post‐eEVs treatment. Additionally, metabolomics analyses show that eEV treatment causes significant changes in the metabolic profile of inflamed lungs, driving the secretion of key anti‐inflammatory metabolites. Altogether, these results establish the potential of eEVs derived from dermal fibroblasts to reduce inflammation, tissue damage, and the prevalence/progression of injury during ARDS via nonviral delivery of anti‐inflammatory genes/transcripts.

show abstract

Extracellular Vesicles: A Double-Edged Sword in Sepsis

Cited by 35 publications

References 132 publications

Pathogenesis of Multiple Organ Failure: The Impact of Systemic Damage to Plasma Membranes

Pathogenesis of Multiple Organ Failure: The Impact of Systemic Damage to Plasma Membranes

Extracellular Vesicles, New Players in Sepsis and Acute Respiratory Distress Syndrome

Engineered Extracellular Vesicles Derived from Dermal Fibroblasts Attenuate Inflammation in a Murine Model of Acute Lung Injury

Contact Info

Product

Resources

About