Extracellular vesicle microRNAs mediate skeletal muscle myogenesis and disease

Wang, Haidong; Wang, Bin

doi:10.3892/br.2016.725

Cited by 39 publications

(30 citation statements)

References 72 publications

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“…Changes in the expression profile of miRNAs may indicate the presence and/or the progression of diseases that affect the muscle ( 7 , 37 , 42 ). Alterations such as the upregulation or downregulation of miRNAs have hence been investigated, having provided clear evidence that they can regulate pathways implicated with myogenesis, and skeletal muscle hypertrophy and atrophy ( 7 , 37 , 42 – 44 ). One of the miRNAs whose concentration is increased, as identified in cancer patients, is miR-21.…”

Section: Myomirs and Cancer Cachexiamentioning

confidence: 99%

“…Muscle mass loss during cachexia is related with an increase in protein degradation and metabolic changes in the muscle, in response to the presence of the tumor in the organism ( 42 ). Soares et al ( 43 ) observed different profiles of alterations in miRNA expression with in vitro and in vivo approaches in four different animal models of skeletal muscle wasting: starvation, denervation, diabetes, and cancer cachexia.…”

Section: Myomirs and Cancer Cachexiamentioning

confidence: 99%

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Role of Exosomal MicroRNAs and myomiRs in the Development of Cancer Cachexia-Associated Muscle Wasting

et al. 2018

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Cachexia is a complex metabolic syndrome that promotes great weight loss, with marked muscle mass wasting. In the last years, many efforts have been directed to improve the understanding of the mechanisms involved in the disease. This syndrome is present in up to 80% of cancer patients and, despite its clinical relevance, is underdiagnosed. The orchestration of the molecular and biochemical disruptions observed in cachexia is paralleled by inflammation and the communication among the different body compartments, including the tumor and the skeletal muscle, is still not completely described. One of the mechanisms that may be involved in the transduction of the inflammatory signals and the activation of catabolic status in muscle is the participation of exosomes containing microRNAs (miRNAs) and muscle-specific miRNAs (myomiRs). Exosomes are nanovesicles, measuring from 30 to 100 µm, and able to carry miRNAs in the circulation, promoting cell–cell and tissue–tissue communication in an autocrine, paracrine, and endocrine manner. miRNAs transported in exosomes are preserved from degradation, while these nanoparticles deliver the cargo to specific cell targets, making communication more efficient. Several miRNAs are known to modulate inflammatory pathways, to induce metastasis, to mediate cancer aggressiveness and even to participate in the regulation of protein synthesis and degradation pathways in the skeletal muscle. The aim of this mini-review is to describe the present knowledge about the role of exosomal miRNAs and myomiRs in the induction of muscle mass wasting in cancer cachexia state and to explain which transcription factors, proteins, and pathways are regulated by these molecules.

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Section: Myomirs and Cancer Cachexiamentioning

confidence: 99%

Section: Myomirs and Cancer Cachexiamentioning

confidence: 99%

Role of Exosomal MicroRNAs and myomiRs in the Development of Cancer Cachexia-Associated Muscle Wasting

et al. 2018

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“…Therefore, EVs serve as vehicles for the delivery of different signaling molecules, including proteins and lipids [ 65 , 66 ]. In particular, one of the most outstanding roles of EVs is the long-distance transport of RNA, which represents a complex mechanism of transcriptional regulation in both mammals and plants [ 67 , 68 ].…”

Section: Vesicles Containing Aquaporins and Communication Between mentioning

confidence: 99%

The Expanding Role of Vesicles Containing Aquaporins

Martínez-Ballesta

García-Ibáñez

Yepes-Molina

et al. 2018

Cells

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In animals and plants, membrane vesicles containing proteins have been defined as key for biological systems involving different processes such as trafficking or intercellular communication. Docking and fusion of vesicles to the plasma membrane occur in living cells in response to different stimuli, such as environmental changes or hormones, and therefore play an important role in cell homeostasis as vehicles for certain proteins or other substances. Because aquaporins enhance the water permeability of membranes, their role as proteins immersed in vesicles formed of natural membranes is a recent topic of study. They regulate numerous physiological processes and could hence serve new biotechnological purposes. Thus, in this review, we have explored the physiological implications of the trafficking of aquaporins, the mechanisms that control their transit, and the proteins that coregulate the migration. In addition, the importance of exosomes containing aquaporins in the cell-to-cell communication processes in animals and plants have been analyzed, together with their potential uses in biomedicine or biotechnology. The properties of aquaporins make them suitable for use as biomarkers of different aquaporin-related diseases when they are included in exosomes. Finally, the fact that these proteins could be immersed in biomimetic membranes opens future perspectives for new biotechnological applications.

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“…Exosomes are major tools of cross talk between cells throughout the body and miRNAs are one of the elements they transport. Some miRNAs, such as miR-206, have been identified as promoters of skeletal muscle development and differentiation [54]. Therefore, miRNAmediated induction of skeletal muscle from human iPSCs is a topic of great interest.…”

Section: Co-culture Exosomes and Mirnamentioning

confidence: 99%

Making Skeletal Muscle from Human Pluripotent Stem Cells

Nogami¹,

Blanc²,

Takemura³

et al. 2018

Muscle Cell and Tissue - Current Status of Research Field

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Human pluripotent stem cells (hPSCs) proliferate in vitro for long periods without losing pluripotency and can be induced to differentiate into various cell types including skeletal muscle cells (SMCs). Human embryonic stem cells (hESCs) are generated from a preimplantation-stage embryo. Human-induced pluripotent stem cells (hiPSCs) are derived from somatic cells of both healthy donors and patients with muscle diseases of any age using reprogramming factors. Currently, there are two kinds of protocols to induce skeletal muscle from hPSCs. One type utilizes overexpression of a potent myogenic master regulator, MyoD, to directly induce skeletal muscle. Stepwise induction of skeletal muscle has also been reported by many research groups, but hiPSC-based cell therapy for muscular dystrophy is still experimental. On the other hand, hiPSCs derived from patients with muscle disease are widely used for disease modeling in vitro. Here, we review the recent literature on derivation of skeletal muscle from human pluripotent stem cells and discuss their application.

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Extracellular vesicle microRNAs mediate skeletal muscle myogenesis and disease

Cited by 39 publications

References 72 publications

Role of Exosomal MicroRNAs and myomiRs in the Development of Cancer Cachexia-Associated Muscle Wasting

Role of Exosomal MicroRNAs and myomiRs in the Development of Cancer Cachexia-Associated Muscle Wasting

The Expanding Role of Vesicles Containing Aquaporins

Making Skeletal Muscle from Human Pluripotent Stem Cells

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