Extracellular vesicle-mediated transfer of BACH1 from macrophage promotes vascular smooth muscle cell proliferation via suppressing FNDC5 expression
Ying Tong,
Dan-Dan Wang,
Tao Lu
et al.
Abstract:Objectives: Extracellular vesicles (EVs) derived from macrophages play crucial roles in the proliferation of vascular smooth muscle cells (VSMCs) and hypertensive vascular remodeling. However, the role of BTB and CNC homology 1 (BACH1) in the EVs regulates VSMC proliferation and vascular remodeling is still unclear.
Methods: Normotensive Wistar-Kyoto rat (WKY) and spontaneously hypertensive (SHR) rat were used as animal models. Primary macrophages and VSMCs were used to study the molecular mechanism. Ultracent… Show more
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