2017
DOI: 10.1111/gtc.12521
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Extracellular vesicle‐mediated MFG‐E8 localization in the extracellular matrix is required for its integrin‐dependent function in mouse mammary epithelial cells

Abstract: Milk fat globule-EGF factor 8 (MFG-E8) is a divalent-binding secretory protein possessing an Arg-Gly-Asp (RGD) motif and a phosphatidylserine (PS)-binding motif. This protein has been shown to be involved in mammary gland development and morphogenesis. Integrin-binding activity is necessary for these MFG-E8-dependent cell processes. Although the target cells and molecules of MFG-E8 in the cellular microenvironment are important to understand its physiological function, its localization is largely unclear. Here… Show more

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Cited by 6 publications
(4 citation statements)
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“…MFG-E8 is broadly expressed in different organs and tissues (e.g., spleen, liver, lungs, kidneys, intestine, and mammary glands) by macrophages, DCs, fibroblasts, epithelial cells and osteoclasts [149,150]. Integrin-binding activity is essential for a wide variety of MFG-E8-mediated efferocytosis-dependent/independent biological functions [151]. MFG-E8 inhibits neutrophil migration through αVβ3-integrin-mediated MAP kinase activation [152].…”
Section: Biological Functions Of Ps Recognition By Mfg-e8mentioning
confidence: 99%
“…MFG-E8 is broadly expressed in different organs and tissues (e.g., spleen, liver, lungs, kidneys, intestine, and mammary glands) by macrophages, DCs, fibroblasts, epithelial cells and osteoclasts [149,150]. Integrin-binding activity is essential for a wide variety of MFG-E8-mediated efferocytosis-dependent/independent biological functions [151]. MFG-E8 inhibits neutrophil migration through αVβ3-integrin-mediated MAP kinase activation [152].…”
Section: Biological Functions Of Ps Recognition By Mfg-e8mentioning
confidence: 99%
“…Humoral responses against EDIL3 observed in Ipi-Bev–treated patients prompted us to look at MFGE8, another angiogenic protein studied previously for potential immunotherapeutic targeting ( 21 ). MFGE8 shares structural and functional homology with EDIL3 ( 22 ). MFGE8 is a potent soluble angiogenic factor that drives the progression of melanomas.…”
Section: Resultsmentioning
confidence: 99%
“…And, if it is, does lactadherin have a pro-tumorigenic role in these EVs? The literature suggests that lactadherin can have a scaffolding role to anchor EVs to their recipient cells or to extracellular matrix components [ 89 ]. One study describing the presence of lactadherin associated with EVs in a kidney cell line suggested a possible role of this protein in membrane secretion processes, such as budding or shedding of plasma membrane (microvesicles) and endocytic multivesicular bodies (exosomes) [ 90 ].…”
Section: Role and Use Of Lactadherin In Evs And Exosomesmentioning
confidence: 99%
“…Particularly in the case of breast tissue (normal or tumor), there are few studies describing the presence of lactadherin associated with exosomes or EVs. One of these articles indicates that lactadherin in EVs is required to transduce cellular signals from the basolateral side of adherent cells by accumulating exosomes in mammary epithelial cells [ 89 ]. However, this report did not describe the presence of lactadherin on the exosomes.…”
Section: Role and Use Of Lactadherin In Evs And Exosomesmentioning
confidence: 99%